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    Mims' medical microbiology.

    • Title:Mims' medical microbiology.
    •    
    • Variant Title:Medical microbiology
    • Other Contributors/Collections:Goering, Richard V.
    • Published/Created:[London] : Elsevier/Saunders, ©2013.
    • Holdings

       
    • Library of Congress Subjects:Medical microbiology.
    • Medical Subjects: Communicable Diseases--microbiology.
    • Edition:5th ed. / Richard V. Goering ... [et al.].
    • Description:xiv, 565 pages : illustrations (chiefly color) ; 28 cm.
    • Summary:Using a clinically relevant, systems-based approach, this medical textbook accessibly explains the microbiology of the agents that cause diseases and the diseases that affect individual organ systems. With lavish illustrations and straightforward, accessible explanations, Richard Goering makes this complex subject simple to understand and remember. 150 multiple choice review questions. "Pathogen Parade" and many other features to enhance learning and retention. Enhance your learning and absorb complex information in an interactive, dynamic way. Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine. A completely re-written chapter on this topic keeps abreast of the very latest findings.
    • Notes:Previous ed.: London: Mosby, 2008.
      Includes Internet access.
      Includes bibliographical references and index.
    • ISBN:9780723436010 (pbk.)
      0723436010 (pbk.)
    • Contents:Machine generated contents note: SECTION 1 ADVERSARIES-MICROBES
      1. Microbes as parasites
      varieties of microbes
      Living inside or outside cells
      Systems of classification
      2. bacteria
      Structure
      Nutrition
      Growth and division
      Gene expression
      Survival underadverse conditions
      Mobile genetic elements
      Mutation and gene transfer
      genomics of medically important bacteria
      3. viruses
      Infection of host cells
      Replication
      Outcome of viral infection
      Major groups of viruses
      4. fungi
      Major groups of disease-causing fungi
      5. protozoa
      6. helminths and arthropods
      helminths
      arthropods
      7. Prions
      `Rogue protein' pathogenesis
      Development, transmission and diagnosis of prion diseases
      Prevention and treatment of prion diseases
      8. host-parasite relationship
      normal flora
      Symbiotic associations
      characteristics of parasitism
      evol ution of parasitism
      SECTION 2 ADVERSARIES-HOST DEFENCES
      9. innate defences of the body
      Defence against entry into the body
      Defences once the microorganism penetrates the body
      10. Adaptive responses provide a `quantum leap' in effective defence
      role ofantibodies
      role of Tlymphocytes
      Extracellular attack on large infectious agents
      Local defences at mucosal surfaces
      11. cellular basis of adaptive immune responses
      B- and T-cell receptors
      Clonal expansion of lymphocytes
      role of memory cells
      Stimulation of lymphocytes
      Cytokines
      Regulatory mechanisms
      Tolerance mechanisms
      SECTION 3 CONFLICTS
      12. Background to the infectious diseases
      Host-parasite relationships
      Causes of infectious diseases
      biologic response gradient
      13. Entry, exit and transmission
      Sites of entry
      Exit and transmission
      Types of transmission between humans
      Transmission from animals
      14. Immune defences in action
      Complement
      Acute phase proteins and pattern recognition receptors
      Fever
      Natural killer cells
      Phagocytosis
      Cytokines
      Antibody-mediated immunity
      Cell-mediated immunity
      Recovery from infection
      15. Spread and replication
      Features of surface and systemic infections
      Mechanisms of spread through the body
      Genetic determinants of spread and replication
      Other factors affecting spread and replication
      16. Parasite survival strategies and persistent infections
      Parasite survival strategies
      Antigenic variation
      Immunosuppression
      Persistent infections
      17. Pathologic consequences of infection
      Pathology caused directly by microorganism
      Diarrhea
      Pathologic activation of natural immune mechanisms
      Pathologic consequences of the immune response
      Skin rashes
      Viruses and cancer
      SECTION 4 CLINICAL MANIFESTATION AND DIAGNOSIS OF INFECTIONS BY BODY SYSTEM
      Introduction to Section 4: The clinical manifestations of infection
      18. Upper respiratory tract infections
      Rhinitis
      Pharyngitis and tonsillitis
      Parotitis
      Otitis and sinusitis
      Acute epiglottitis
      Oral cavity infections
      19. Lower respiratory tract infections
      Laryngitis and tracheitis
      Diphtheria
      Whooping cough
      Acute bronchitis
      Acute exacerbations of chronic bronchitis
      Bronchiolitis
      Respiratory syncytial virus infection
      Hantavirus pulmonary syndrome (HPS)
      Pneumonia
      Bacterial pneumonia
      Viral pneumonia
      Parainfluenza virus infection
      Adenovirus infection
      Human metapneumovirus
      Human bocavirus
      Influenza virus infection
      Severe acute respiratory syndrome-associated coronavirus infection
      Measles
      Cytomegalovirus infection
      Tuberculosis
      Cystic fibrosis
      Lung abscess
      Fungal infections
      Parasitic infections
      20. Urinary tract infections
      Acquisition and aetiology
      Pathogenesis
      Clinical features and complications
      Laboratory diagnosis
      Treatment
      Prevention
      21. Sexually transmitted infections
      STIs and sexual behaviour
      Syphilis
      Gonorrhoea
      Chlamydial infection
      Other causes of inguinal lymphadenopathy
      Mycoplasmas and non-gonococcal urethritis
      Othercauses ofvaginitis and urethritis
      Genital herpes
      Human papillomavirus infection
      Human immunodeficiency virus
      Opportunist STIs
      Arthropod infestations
      22. Gastrointestinal tract infections
      Diarrheal diseases caused by bacterial or viral infection
      Food poisoning
      Helicobacter pylori and gastric ulcer disease
      Parasites and the gastrointestinal tract
      Systemic infection initiated in the gastrointestinal tract
      23. Obstetric and perinatal infections
      Infections occurring in pregnancy
      Congenital infections
      Infections occurring around thetime of birth
      24. Central nervous system infections
      Invasion of the central nervous system
      body's response to invasion
      Meningitis
      Encephalitis
      Neurologic diseases of possible viral aetiology
      Spongiform encephalopathies caused by scrapie-type agents
      CNS disease caused by parasites
      Brain abscesses
      Tetanus and botulism
      25. Infections of the eye
      Conjunctivitis
      Infection of the deeper layers of the eye
      26. Infections of the skin, soft tissue, muscle and associated systems
      Bacterial infections of skin, soft tissue and muscle
      Mycobacterial diseases of the skin
      Fungal infections of the skin
      Parasitic infections of the skin
      Mucocutaneous lesions caused by viruses
      Smallpox
      Measles
      Rubella
      Other infections producing skin lesions
      Kawasaki syndrome
      Viral infections of muscle
      Parasitic infections of muscle
      Joint and bone infections
      Infections of the haemopoietic system
      27. Vector-borne infections
      Arbovirus infections
      Infections caused by rickettsiae
      Borrelia infections
      Protozoal infections
      Helminth infections
      28. Multisystem zoonoses
      Arenavirus infections
      Haemorrhagic fever with renal syndrome (HFRS)
      Marburg and Ebola haemorrhagic fevers
      Crimean-Congo haemorrhagic fever, a tick-borne virus
      Q fever
      Anthrax
      Plague
      Yersinia enterocolitica infection
      Tularemia
      Pasteurellamultocida infection
      Leptospirosis
      Rat-bite fever
      Brucellosis
      Helminth infections
      29. Fever of unknown origin
      Definitions of fever of unknown origin
      Causes of FUO
      Investigation of classic FUO
      Treatment of FUO
      FUO in specific patient groups
      Infective endocarditis
      30. Infections in the compromised host
      compromised host
      Infections ofthe host with deficient innate immunity due to physical factors
      Infections associated with secondary adaptive immunodeficiency
      Other important opportunist pathogens
      SECTION 5 DIAGNOSIS AND CONTROL
      31. Diagnosis of infection and assessment of host defense mechanisms
      Aims of the clinical microbiology laboratory
      Specimen processing
      Non-cultural techniques for the laboratory diagnosis of infection
      Cultivation (culture) of microorganisms
      Identification of microorganisms grown in culture
      Antibody detection methods for the diagnosis of infection
      Assessment of host defence systems
      Putting it all together: detection, diagnosis, and epidemiology
      32. Epidemiology and control of infectious diseases
      Outcome measurements
      Types of epidemiological studies
      Transmission of infectious disease
      Vaccine efficacy
      33. Attacking the enemy: antimicrobial agents and chemotherapy
      Selective toxicity
      Discovery and design of antimicrobial agents
      Classification of antibacterial agents
      Resistance to antibacterial agents
      Classes of antibacterial agents
      Inhibitors of cell wall synthesis
      Inhibitors of protein synthesis
      Inhibitors of nucleic acid synthesis
      Antimetabolites affecting nucleic acid synthesis
      Other agents that affect DNA
      Inhibitors of cytoplasmic membrane function
      Urinary tract antiseptics
      Antituberculosis agents
      Antibacterial agents in practice
      Antibiotic assays
      Antiviral therapy
      Antifungal agents
      Antiparasitic agents
      Control by chemotherapy versus vaccination
      Control versus eradication
      Use and misuse of antimicrobial agents
      34. Protecting the host: vaccination
      vaccination - A four hundred year history
      Aims of vaccination
      Vaccines can be of different types
      35. Passive and non-specific immunotherapy
      Passive immunization with antibody
      Non-specific cellular immunostimulation
      Correction of host immunodeficiency
      Probiotics
      36. Hospital infection, sterilization and disinfection
      Common hospital infections
      Important causes of hospital infection
      Sources and routes of spread of hospital infection
      Host factors and hospital infection
      Consequences of hospital infection
      Prevention of hospital infection
      Investigating healthcare-associated infection
      Sterilization and disinfection.
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