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    Infection and immunity.

    • Title:Infection and immunity.
    •    
    • Variant Title:Infection & immunity
    • Author/Creator:Playfair, J. H. L.
    • Other Contributors/Collections:Bancroft, Gregory J.
    • Published/Created:Oxford : Oxford University Press, 2013.
    • Holdings

       
    • Library of Congress Subjects:Immunology.
      Infection.
    • Medical Subjects: Immunity--immunology.
    • Edition:4th ed. / John H.L. Playfair, Gregory J. Bancroft.
    • Description:xvi, 381 p. : col. ill. ; 25 cm
    • Summary:The authors describe the main causes of infection that our bodies have to battle against - from bacteria to viruses - and explain the intricate and fascinating way that our bodies respond to infection - from detection of these potentially dangerous organisms, to their ultimate elimination.
    • Notes:Previous ed.: 2008.
      Includes bibliographical references and index.
    • ISBN:9780199609505 (pbk.)
      0199609500 (pbk.)
    • Contents:Machine generated contents note: pt. ONE infectious organisms
      1. Introduction: parasites, pathogens, and immunity
      Pathogens
      Infectious disease
      Immunity
      Summary
      2. Viruses
      Viral structure, replication, and function
      Viral spread
      Control of viruses
      Summary
      3. Bacteria
      Classification; the cell wall
      Bacterial metabolism
      Atypical bacteria
      Bacterial genetics and reproduction
      Disease and immunity
      Control of bacteria
      Useful bacteria
      Summary
      4. Fungi
      Structure and morphology
      Cutaneous and superficial mycoses
      Subcutaneous mycoses
      Systemic mycoses
      Control of fungi
      Useful fungi
      Summary
      5. Protozoa
      Malaria
      Leishmania
      Trypanosomes
      Toxoplasma
      Amoebae
      Giardia, Cryptosporidium, Trichomonas
      Control of protozoa
      Summary
      6. Helminths (worms)
      General structure and function
      Schistosomes and other trematodes (flukes)
      Nematodes (roundworms)
      Cestodes (tapeworms)
      Control of helminths
      Summary
      7. Ectoparasites
      Mites
      Ticks
      Lice
      Fleas
      Other insect vectors
      8. Prions
      Summary
      9. Disease: virulence and susceptibility
      Virulence factors
      Genomics and virulence
      Genetics of host susceptibility
      Disease directly due to the pathogen
      Diarrhoea and vomiting
      Summary
      Tutorial 1
      Further reading and information
      pt. TWO immune system
      10. Defence, immunity, the immune system
      Three levels of defence
      External defences
      immune system
      Innate and adaptive immunity
      Summary
      11. External defences: entry and exit
      External defences can be physical or chemical
      skin
      respiratory tract
      intestine
      urogenital tract
      eye
      maternal-fetal route
      How pathogens exit
      note on vectors
      Summary
      12. Innate immunity
      Pattern recognition by the innate immune system
      Soluble (humoral) mediators of innate immunity
      Cells of innate immunity
      Lymphoid cells of innate immunity
      Acute inflammation
      Interaction with adaptive immunity
      Summary
      13. How pathogens escape innate immunity
      Avoiding pattern recognition
      Avoiding complement
      Avoiding phagocytosis
      Avoiding NK cells
      Interference with dendritic cell function
      Interference with the cytokine network
      role of vectors
      Summary
      14. Disease due to innate immunity
      Sepsis and septic shock
      Endotoxin, cytokines, and disease
      Complement and disease
      Polymorphs, mast cells, and disease
      Summary
      15. Immunodeficiency I: primary defects of innate immunity
      Genetics of primary immunodeficiency
      Primary defects of innate immunity
      Secondary immunodeficiency
      Summary
      Tutorial 2
      16. Adaptive immunity: introduction
      lymphocyte
      lymphoid system
      Recirculation
      Antigen and antigen-recognition molecules
      Clonal selection and memory
      Regulation of adaptive immunity
      Summary
      17. B cells and antibody
      antibody molecule
      Antibody classes and subclasses
      antigen-binding site and antigenic determinants
      Antibody affinity
      What antibodies do
      antibody industry
      Summary
      18. T cells and the MHC
      Subpopulations of T cells
      What T cells recognize
      Antigen-presenting molecules
      T-cell receptor
      Antigen processing and presentation
      Superantigens
      γδ cells
      NKT cells
      Summary
      19. antibody response
      Activation of B cells
      Presentation of antigen to T cells
      Activation of T cells
      T-cell help
      B-cell memory
      Antibody responses at mucosal surfaces
      Summary
      20. Cell-mediated responses
      T-cell activation
      Effector functions 1 activation of macrophages and other cells
      Effector functions 2 cytotoxicity
      T-cell memory
      T-cell responses at mucosal surfaces
      TH1, TH2, and TH17 T cells
      Summary
      21. Regulation of immune responses and memory
      Elimination of antigen
      Apoptosis
      Inhibitory receptors
      Regulation by T cells
      Therapeutic regulation
      Memory
      Generation of memory cells
      Activation and response of memory cells
      Maintenance of memory cells
      Summary
      22. How pathogens escape adaptive immunity
      Concealment
      Antigenic variation
      Immunosuppression
      Pregnancy, transplants, and tumours
      Summary
      23. Disease due to adaptive immunity I: hypersensitivity
      Type I (allergic) hypersensitivity
      Type II (cytotoxic) hypersensitivity
      Type III (immune complex-mediated) hypersensitivity
      Type IV (cell-mediated) hypersensitivity
      Summary
      24. Disease due to adaptive immunity II: autoimmunity
      Self-tolerance
      Polyclonal lymphocyte activation
      Antigen mimicry
      Release of sequestered antigens
      Anomalous antigen presentation
      Anomalous cytokine production
      Autoimmunity, autoimmune disease, and genetics
      Summary
      25. Immunodeficiency II: primary defects of adaptive immunity
      Defects affecting T and B cells
      Defects affecting T cells
      Defects affecting B cells and antibody
      Clinical aspects of primary immune deficiencies
      Summary
      26. Immunodeficiency III: secondary immunodeficiency and AIDS
      Malnutrition
      Infection
      Other causes of immunodeficiency
      Infections in the immunodeficient patient
      Summary
      Tutorial 3
      Further reading and information
      pt. THREE host-pathogen balance
      27. Epidemiology
      Diagnosing, monitoring, and predicting disease
      HIV and AIDS
      Tuberculosis
      Malaria
      Acute infantile respiratory disease
      Infantile diarrhoea
      value of epidemiology
      Summary
      28. Control of infectious disease: vaccination
      Requirements for a vaccine
      Established vaccines
      Other vaccine strategies
      Immunological correlates of protection
      Development and testing
      Passive (`immediate') immunization
      Non-specific immunostimulation
      Therapeutic vaccines
      Future prospects
      Summary
      29. Control of infectious disease: chemotherapy
      Antibacterial agents
      Antibiotic resistance
      Toxicity
      Antiviral drugs
      Drugs against fungi, protozoa, and worms
      Chemotherapy and the immune system
      Summary
      30. Control of infectious disease: public health measures
      Science, politics, and ethics
      Vector control
      Animals without pathogens?
      Summary
      31. Viral and prion disease and immunity
      common childhood viruses
      common cold
      Influenza
      Glandular fever
      Poliomyelitis
      Viral hepatitis
      Rabies
      Other viral zoonoses
      Yellow fever and dengue
      Papilloma viruses
      Retroviruses
      Prion diseases
      Summary
      32. Bacterial disease and immunity
      Staphylococcal infection
      Streptococcal infection
      Clostridial infections
      Anthrax
      Diphtheria
      Tuberculosis
      Whooping cough
      Meningococcal meningitis
      Gonorrhoea
      Syphilis
      Typhoid
      Plague
      Tularemia
      Brucellosis
      Actinomycosis
      Chlamydial infection
      Rickettsial infection
      Mycoplasma infection
      Summary
      33. Fungal disease and immunity
      Primary superficial and subcutaneous infections
      Systemic infections
      Opportunistic fungi
      Treatment and vaccines
      Summary
      34. Protozoal disease and immunity
      Malaria
      Leishmaniasis
      African trypanosomiasis
      South American trypanosomiasis (Chagas' disease)
      Toxoplasmosis
      Amoebiasis
      Summary
      35. Helminth disease and immunity
      Schistosomiasis
      Filariasis
      Hydatid disease
      Worms, IgE, and allergy
      Summary
      36. Ectoparasites and immunity
      Leishmaniasis and the sandfly
      Ticks and immunomodulation
      Mosquitoes and malaria
      Tsetse flies and trypanosomiasis
      Simulium (blackfly) and onchocerciasis
      Chagas' disease and the reduviid (`kissing') bug
      Mites, allergy, and resistance
      37. Emerging and future infectious diseases
      Newly identified pathogens
      Newly acquired zoonoses
      Opportunistic infections
      Changes in virulence
      Artificial creation of new pathogens
      Drug resistance
      Vaccine uptake
      Public health
      Travel and immigration
      Climate change
      Summary
      Tutorial 4
      Further reading and information.
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