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Infection and immunity.
Bibliographic Record Display
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Title:Infection and immunity.
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Variant Title:Infection & immunity
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Author/Creator:Playfair, J. H. L.
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Other Contributors/Collections:Bancroft, Gregory J.
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Published/Created:Oxford : Oxford University Press, 2013.
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Holdings
Holdings Record Display
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Location:BMB LIBRARY (VGH) stacksWhere is this?
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Call Number: QW540 .P722ia 2013
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Number of Items:1
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Status:Available
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Location:OKANAGAN LIBRARY stacksWhere is this?
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Call Number: QW540 .P722ia 2013
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Number of Items:1
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Status:Available
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Location:WOODWARD LIBRARY stacksWhere is this?
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Call Number: QW540 .P722ia 2013
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Number of Items:1
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Status:Available
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Location:BMB LIBRARY (VGH) stacksWhere is this?
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Library of Congress Subjects:Immunology.
Infection.
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Medical Subjects: Immunity--immunology.
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Edition:4th ed. / John H.L. Playfair, Gregory J. Bancroft.
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Description:xvi, 381 p. : col. ill. ; 25 cm
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Summary:The authors describe the main causes of infection that our bodies have to battle against - from bacteria to viruses - and explain the intricate and fascinating way that our bodies respond to infection - from detection of these potentially dangerous organisms, to their ultimate elimination.
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Notes:Previous ed.: 2008.
Includes bibliographical references and index.
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ISBN:9780199609505 (pbk.)
0199609500 (pbk.)
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Contents:Machine generated contents note: pt. ONE infectious organisms
1. Introduction: parasites, pathogens, and immunity
Pathogens
Infectious disease
Immunity
Summary
2. Viruses
Viral structure, replication, and function
Viral spread
Control of viruses
Summary
3. Bacteria
Classification; the cell wall
Bacterial metabolism
Atypical bacteria
Bacterial genetics and reproduction
Disease and immunity
Control of bacteria
Useful bacteria
Summary
4. Fungi
Structure and morphology
Cutaneous and superficial mycoses
Subcutaneous mycoses
Systemic mycoses
Control of fungi
Useful fungi
Summary
5. Protozoa
Malaria
Leishmania
Trypanosomes
Toxoplasma
Amoebae
Giardia, Cryptosporidium, Trichomonas
Control of protozoa
Summary
6. Helminths (worms)
General structure and function
Schistosomes and other trematodes (flukes)
Nematodes (roundworms)
Cestodes (tapeworms)
Control of helminths
Summary
7. Ectoparasites
Mites
Ticks
Lice
Fleas
Other insect vectors
8. Prions
Summary
9. Disease: virulence and susceptibility
Virulence factors
Genomics and virulence
Genetics of host susceptibility
Disease directly due to the pathogen
Diarrhoea and vomiting
Summary
Tutorial 1
Further reading and information
pt. TWO immune system
10. Defence, immunity, the immune system
Three levels of defence
External defences
immune system
Innate and adaptive immunity
Summary
11. External defences: entry and exit
External defences can be physical or chemical
skin
respiratory tract
intestine
urogenital tract
eye
maternal-fetal route
How pathogens exit
note on vectors
Summary
12. Innate immunity
Pattern recognition by the innate immune system
Soluble (humoral) mediators of innate immunity
Cells of innate immunity
Lymphoid cells of innate immunity
Acute inflammation
Interaction with adaptive immunity
Summary
13. How pathogens escape innate immunity
Avoiding pattern recognition
Avoiding complement
Avoiding phagocytosis
Avoiding NK cells
Interference with dendritic cell function
Interference with the cytokine network
role of vectors
Summary
14. Disease due to innate immunity
Sepsis and septic shock
Endotoxin, cytokines, and disease
Complement and disease
Polymorphs, mast cells, and disease
Summary
15. Immunodeficiency I: primary defects of innate immunity
Genetics of primary immunodeficiency
Primary defects of innate immunity
Secondary immunodeficiency
Summary
Tutorial 2
16. Adaptive immunity: introduction
lymphocyte
lymphoid system
Recirculation
Antigen and antigen-recognition molecules
Clonal selection and memory
Regulation of adaptive immunity
Summary
17. B cells and antibody
antibody molecule
Antibody classes and subclasses
antigen-binding site and antigenic determinants
Antibody affinity
What antibodies do
antibody industry
Summary
18. T cells and the MHC
Subpopulations of T cells
What T cells recognize
Antigen-presenting molecules
T-cell receptor
Antigen processing and presentation
Superantigens
γδ cells
NKT cells
Summary
19. antibody response
Activation of B cells
Presentation of antigen to T cells
Activation of T cells
T-cell help
B-cell memory
Antibody responses at mucosal surfaces
Summary
20. Cell-mediated responses
T-cell activation
Effector functions 1 activation of macrophages and other cells
Effector functions 2 cytotoxicity
T-cell memory
T-cell responses at mucosal surfaces
TH1, TH2, and TH17 T cells
Summary
21. Regulation of immune responses and memory
Elimination of antigen
Apoptosis
Inhibitory receptors
Regulation by T cells
Therapeutic regulation
Memory
Generation of memory cells
Activation and response of memory cells
Maintenance of memory cells
Summary
22. How pathogens escape adaptive immunity
Concealment
Antigenic variation
Immunosuppression
Pregnancy, transplants, and tumours
Summary
23. Disease due to adaptive immunity I: hypersensitivity
Type I (allergic) hypersensitivity
Type II (cytotoxic) hypersensitivity
Type III (immune complex-mediated) hypersensitivity
Type IV (cell-mediated) hypersensitivity
Summary
24. Disease due to adaptive immunity II: autoimmunity
Self-tolerance
Polyclonal lymphocyte activation
Antigen mimicry
Release of sequestered antigens
Anomalous antigen presentation
Anomalous cytokine production
Autoimmunity, autoimmune disease, and genetics
Summary
25. Immunodeficiency II: primary defects of adaptive immunity
Defects affecting T and B cells
Defects affecting T cells
Defects affecting B cells and antibody
Clinical aspects of primary immune deficiencies
Summary
26. Immunodeficiency III: secondary immunodeficiency and AIDS
Malnutrition
Infection
Other causes of immunodeficiency
Infections in the immunodeficient patient
Summary
Tutorial 3
Further reading and information
pt. THREE host-pathogen balance
27. Epidemiology
Diagnosing, monitoring, and predicting disease
HIV and AIDS
Tuberculosis
Malaria
Acute infantile respiratory disease
Infantile diarrhoea
value of epidemiology
Summary
28. Control of infectious disease: vaccination
Requirements for a vaccine
Established vaccines
Other vaccine strategies
Immunological correlates of protection
Development and testing
Passive (`immediate') immunization
Non-specific immunostimulation
Therapeutic vaccines
Future prospects
Summary
29. Control of infectious disease: chemotherapy
Antibacterial agents
Antibiotic resistance
Toxicity
Antiviral drugs
Drugs against fungi, protozoa, and worms
Chemotherapy and the immune system
Summary
30. Control of infectious disease: public health measures
Science, politics, and ethics
Vector control
Animals without pathogens?
Summary
31. Viral and prion disease and immunity
common childhood viruses
common cold
Influenza
Glandular fever
Poliomyelitis
Viral hepatitis
Rabies
Other viral zoonoses
Yellow fever and dengue
Papilloma viruses
Retroviruses
Prion diseases
Summary
32. Bacterial disease and immunity
Staphylococcal infection
Streptococcal infection
Clostridial infections
Anthrax
Diphtheria
Tuberculosis
Whooping cough
Meningococcal meningitis
Gonorrhoea
Syphilis
Typhoid
Plague
Tularemia
Brucellosis
Actinomycosis
Chlamydial infection
Rickettsial infection
Mycoplasma infection
Summary
33. Fungal disease and immunity
Primary superficial and subcutaneous infections
Systemic infections
Opportunistic fungi
Treatment and vaccines
Summary
34. Protozoal disease and immunity
Malaria
Leishmaniasis
African trypanosomiasis
South American trypanosomiasis (Chagas' disease)
Toxoplasmosis
Amoebiasis
Summary
35. Helminth disease and immunity
Schistosomiasis
Filariasis
Hydatid disease
Worms, IgE, and allergy
Summary
36. Ectoparasites and immunity
Leishmaniasis and the sandfly
Ticks and immunomodulation
Mosquitoes and malaria
Tsetse flies and trypanosomiasis
Simulium (blackfly) and onchocerciasis
Chagas' disease and the reduviid (`kissing') bug
Mites, allergy, and resistance
37. Emerging and future infectious diseases
Newly identified pathogens
Newly acquired zoonoses
Opportunistic infections
Changes in virulence
Artificial creation of new pathogens
Drug resistance
Vaccine uptake
Public health
Travel and immigration
Climate change
Summary
Tutorial 4
Further reading and information.