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• Title:Principles and practice of toxicology in public health / Ira S. Richards, Marie M. Bourgeois.
  
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• Author/Creator:Richards, Ira S. (Ira Steven), 1948-
  
• Other Contributors/Collections:Bourgeois, Marie M.
  
• Published/Created:Burlington, Mass. : Jones & Bartlett Learning, ©2014.
  

• Holdings

  Holdings Record Display

  • Location:BMB LIBRARY (VGH) stacksWhere is this?
    
  • Call Number: QV600 .R52 2014
    
  • Number of Items:1
    
  • Status:Available
    

  • Location:WOODWARD LIBRARY stacksWhere is this?
    
  • Call Number: QV600 .R52 2014
    
  • Number of Items:1
    
  • Status:Available
    

   
• Library of Congress Subjects:Toxicology.
  
• Medical Subjects: Toxicology.
  Health Policy.
  Public Health Practice.
  Risk Assessment.
  
• Edition:2nd ed.
  
• Description:xv, 522 pages : illustrations (some color) ; 26 cm
  
• Summary:All public health professionals should have some level of knowledge of the basic principles of Toxicology. Whether dealing with issues as diverse as a workers' compensation claim for a job-related exposure and injury or the removal of toxic wastes from an urban community, public health professionals must be able to communicate with each other, the public, and our political leaders concerning how chemicals can, and the conditions under which they may, realistically produce harm. Principles and Practice of Toxicology in Public Health provides students with an understanding of the nature and scope of the discipline, so that they may be prepared to participate in a meaningful way in the often highly visible problem-solving and decision-making processes required of public health professionals. In four sections, it offers an introduction to the field, as well as the basics of toxicology principles, systemic toxicity, and toxicology practice. The text is immediately readable for the student with little technical background. The Second Edition is a thorough update that has been expanded with a new chapter on endocrine toxicology.
  
• Notes:Includes bibliographical references and index.
  
• ISBN:9781449645267 (pbk.)
  1449645267 (pbk.)
  
• Contents:Machine generated contents note: ch. 1 Toxicology and Its Roots as a Science
  Introduction
  Toxic Chemicals
  Epidemiological Studies
  Causality
  Roots of Toxicology
  Evolution of Toxicology
  Bibliography
  ch. 2 Chemical Properties and Hazardous Chemicals Information Resources
  Introduction
  Elements, Atoms, and Compounds
  Mixtures, Suspensions, and Aerosols
  Identifying Chemicals
  Physical Properties of Chemicals
  Appendix 2-1: Some Web-Based Resources
  Appendix 2-2: Regulatory Agencies That Maintain Lists for Hazardous Chemicals
  Appendix 2-3: Regional Poison Control Centers
  ch. 3 Toxicity and the Factors That Modify Toxic Responses
  Cellular Basis of Toxicity
  Spectrum of Adverse Effects
  Factors That Modify Toxicity
  Toxicogenomics and Its Importance in Public Health
  Bibliography
  ch. 4 Biological Poisons: Plant and Animal Toxins
  Introduction
  Bacterial Toxins
  Fungal Toxins
  Algal Toxins
  Higher Plant Toxins
  Animal Toxins
  Bibliography
  ch. 5 Environmental Pollutants and Their Fate
  Introduction
  Unfortunate Lessons Learned
  Pollution Versus Contamination
  Environmental Chemistry
  Environment: Compartments and Ecosystems
  Toxicity in a Population
  Endocrine-Disrupting Compounds
  Conclusion
  Bibliography
  ch. 6 Dose and Response
  Introduction
  Relating Dose to Response
  Dose-Response Graphs
  How Individuals May Respond in a Population
  Dose Must Be Referenced to Time
  Dose Standardization Based on Body Weight
  Toxicity Rating
  Referencing Dose to Environmental Media
  Bibliography
  ch. 7 Absorption of Toxicants and Models of Disposition
  Toxicant Entry into the Body
  Cell Membranes
  Movement of Toxicants Across Cell Membranes
  Skin Absorption
  Gastrointestinal Absorption
  Respiratory Absorption
  Other Exposure Routes
  Chemical Disposition and Toxicokinetics
  Models of Disposition
  Bibliography
  ch. 8 Distribution, Storage, and Elimination of Toxicants
  Introduction
  Body Water and Volume of Distribution
  Plasma Binding, Blood Flow, and Barriers to Distribution
  Toxicant Storage
  Toxicant Elimination
  Urinary Excretion
  Fecal Elimination
  Pulmonary Elimination
  Minor Routes of Elimination
  Bibliography
  ch. 9 Biotransformation
  Introduction
  Enzymes
  Tissues Where Biotransformation Proceeds
  Phase 1 Reactions and Cytochrome P450
  Phase 2 Reactions
  Bibliography
  ch. 10 Chemical-Induced Mutagenesis
  DNA and Mutations
  Mutations and Apoptosis
  Tests for DNA Damage and Mutagenicity
  Examples of Chemical Mutagens
  Bibliography
  ch. 11 Chemicals and Cancer
  Introduction
  Mutations in Genes That Regulate Cell Growth and Differentiation
  Oncogenes
  History of Chemical Carcinogenesis
  Characteristics of Cancer Cells
  Benign and Malignant Tumors
  Tumor Angiogenesis, Metastasis, and Staging
  Classification Systems for Carcinogens by Agency
  Carcinogen Classification
  Exposure to Carcinogens
  Chemical-Induced Carcinogenesis Is a Multistep Process
  Informing the Public About Carcinogens
  Bibliography
  ch. 12 Role of the Immune System
  Introduction
  Chemical Exposures
  Immune Responses
  Organs of the Immune System
  Cells of the Immune System
  Antibodies
  Immunological Disorders
  Immunosuppression by Toxicants
  Examples of Chemical-Induced Immunological Disorders
  Experimental Immunological Testing
  Bibliography
  ch. 13 Skin
  Introduction
  Structure of the Skin
  Skin Absorption of Chemicals
  Skin Toxicity: Local Effects
  Bibliography
  ch. 14 Liver and Kidneys
  Liver
  Kidneys
  Bibliography
  ch. 15 Cardiovascular System
  General Considerations
  Cardiac Physiology
  Cell Types
  Cardiac Electrophysiology
  Assessing Cardiac Function
  Effects of Toxicants on the Cardiovascular System
  Blood Vessels
  Blood
  Bibliography
  ch. 16 Respiratory System
  General Considerations
  Nomenclature of Airborne Toxicants
  Functional Divisions of the Respiratory System
  Respiratory System Injury
  Exposures to Air Pollutants
  Defense Strategies
  Types of Injury
  Bibliography
  ch. 17 Nervous System
  General Considerations
  Cells of the Nervous System
  Blood-Brain Barrier
  Neuron Action Potential and Synaptic Function
  Neurotoxicity
  Bibliography
  ch. 18 Endocrine System
  General Considerations
  Parts of the Endocrine System
  Reproductive System
  Bibliography
  ch. 19 Practice of Toxicology
  Introduction
  Categories of Toxicologists
  Expectations and Requirements for Toxicologists
  Toxicologists as Expert Witnesses
  Websites
  Bibliography
  ch. 20 Regulatory Considerations
  Standards, Guidelines, and Regulatory Agencies
  Public Awareness and Public Outrage
  Regulatory and Nonregulatory Agencies: Their Role in Protecting the Public from Chemical Exposures
  Industrial Versus Environmental Standards
  Agency for Toxic Substances and Disease Registry
  National Toxicology Program
  Consumer Product Safety Commission
  Websites
  Bibliography
  ch. 21 Toxicity Testing
  Nature and Scope of Toxicity Testing
  Toxicity Test Objectives and Considerations
  Animal Use and Extrapolation to Humans
  Practical Aspects of Measuring Toxicity Experimentally
  Acute Local Toxicity: Tests for Irritancy and Corrosiveness
  Acute Systemic Toxicity: Use and Limitations of LD50
  Efficacy, Toxicity, and Lethality
  Other Examples of Prechronic Toxicity Testing in Laboratory Animals
  Chronic Toxicity Testing in Laboratory Animals
  Human Studies
  Alternative Toxicity Testing Methods
  Examples of In Vitro Tests for Several Toxicological Endpoints
  Conclusion
  Websites
  Bibliography
  Appendix 21-1: Example of a Template for a Subchronic Toxicity Study in Rodents for FDA Review
  ch. 22 Uses and Limitations of Product Labeling for Public Safety
  Purpose of Product Labeling
  Use of Product Labels by Consumers
  Limitations of Product Labels
  Federal Requirements
  FIFRA and Pesticides
  Pesticide Product Labeling
  Product Labels Are Not Material Safety Data Sheets
  Federal Food and Drug Administration Requirements for Labeling
  Websites
  ch. 23 Toxicology Principles in the Management of Acute Poisonings
  Introduction
  Management of Acute Poisoning
  Route of Exposure Influences Toxicity: An Example Using Cocaine
  Intentional and Unintentional Exposures in the American Population
  Inhalant Use
  Toxicities Associated with "Street Drugs"
  Websites
  Bibliography
  ch. 24 Risk Assessment and the Perception of Risk
  Overview of Risk
  Risk Assessment
  Cancer Risk Assessment
  Ecological Risk Assessment
  Toxicant Interaction and Chemical Mixtures
  Responding to Public Concerns
  Websites
  Bibliography
  ch. 25 Making Informed Decisions
  Difficulties in Decision Making
  Risk Assessment in the Federal Government: Managing the Process
  Making the Best Decisions
  CRAM Report
  Websites
  Bibliography.