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• Title:Developmental biology / Scott F. Gilbert, Swarthmore College and the University of Helsinki.
  
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• Author/Creator:Gilbert, Scott F., 1949-
  
• Published/Created:Sunderland, MA, USA : Sinauer Associates, Inc. Publishers, [2014]
  

• Holdings

  Holdings Record Display

  • Location:BMB LIBRARY (VGH) stacksWhere is this?
    
  • Call Number: QL955 .G48 2014
    
  • Number of Items:1
    
  • Status:Available
    

  • Location:WOODWARD LIBRARY stacksWhere is this?
    
  • Call Number: QL955 .G48 2014
    
  • Number of Items:1
    
  • Status:c.1 On loan - Due on 05-15-2024
    

   
• Library of Congress Subjects:Embryology--Textbooks.
  Developmental biology--Textbooks.
  
• Medical Subjects: Embryology.
  Developmental Biology.
  
• Edition:Tenth edition.
  
• Description:xx, 719 pages, 97 variously numbered pages : illustrations (chiefly color) ; 29 cm
  
• Summary:This text explores and synthesizes the organismal, cellular, and molecular aspects of animal development, and expands its coverage of the medical, environmental, and evolutionary aspects of developmental biology. This text features up-to-date research, a new full-colour art program, chapter reorganization and new chapter summaries, and two new chapters -- Mechanisms of Plant Development and Metamorphosis, Regeneration, and Aging.
  
• Notes:Includes index.
  Includes bibliographical references and indexes.
  
• ISBN:9780878939787
  0878939784
  
• Contents:Machine generated contents note: pt. ONE QUESTIONS
  Introducing Developmental Biology
  ch. 1 Comprehending Development
  Generating New Cells and Organs
  Cycle of Life
  Frog's Life
  Gametogenesis and fertilization
  Cleavage and gastrulation
  Organogenesis
  Metamorphosis and gametogenesis
  "How Are You?"
  Comparative embryology
  Epigenesis and preformation
  Naming the parts: The primary germ layers and early organs
  four principles of Karl Ernst von Baer
  Keeping Track of Moving Cells: Fate Maps and Cell Lineages
  Fate maps
  Direct observation of living embryos
  Dye marking
  Genetic labeling
  Transgenic DNA chimeras
  Evolutionary Embryology
  Embryonic homologies
  Medical Embryology and Teratology
  Genetic malformations and syndromes
  Disruptions and teratogens
  ch. 2 Differential Gene Expression in Development
  Evidence for Genomic Equivalence
  Sidelights and Speculations The Basic Tools of Developmental Genetics
  Differential Gene Transcription
  Anatomy of the gene: Active and repressed chromatin
  Anatomy of the gene: Exons and introns
  Anatomy of the gene: Promoters and enhancers
  Enhancer functioning
  Transcription factor function
  Keeping the right genes on or off
  Sidelights and Speculations Reprogramming Cells: Changing Cell Differentiation through Embryonic Transcription Factors
  Mechanisms of Differential Gene Transcription
  Finding DNA regulatory sequences
  Differentiated proteins from high and low CpG-content promoters
  DNA methylation, another key on/off switch of transcription
  "Poised" chromatin
  Sidelights and Speculations Genomic Imprinting and DNA Methylation
  Differential RNA Processing
  Sidelights and Speculations X Chromosome Inactivation: Noncoding RNAs in Transcriptional Gene Regulation
  Creating families of proteins through differential nRNA splicing
  Splicing enhancers and recognition factors
  Control of Gene Expression at the Level of Translation
  Differential mRNA longevity
  Stored oocyte mRNAs: Selective inhibition of mRNA translation
  Ribosomal selectivity: Selective activation of mRNA translation
  microRNAs: Specific regulation of mRNA translation and transcription
  Control of RNA expression by cytoplasmic localization
  Posttranslational Regulation of Gene Expression
  Coda
  ch. 3 Cell-Cell Communication in Development
  Cell Adhesion
  Differential cell affinity
  thermodynamic model of cell interactions
  Cadherins and cell adhesion
  Sidelights and Speculations Shape Change and Epithelial Morphogenesis: "The Force Is Strong in You"
  Cell Migration
  Cell Signaling
  Induction and competence
  Reciprocal induction
  Epithelial-mesenchymal interactions
  Paracrine Factors: Inducer Molecules
  Signal transduction cascades: The response to inducers
  Fibroblast growth factors and the RTK pathway
  JAK-STAT pathway
  Hedgehog family
  Wnt family
  TGF-β superfamily
  Sidelights and Speculations Cell Death Pathways
  Other paracrine factors
  Juxtacrine Signaling
  Notch pathway: Juxtaposed ligands and receptors
  Sidelights and Speculations Juxtacrine Signaling and Cell Patterning
  Extracellular Matrix as a Source of Developmental Signals
  Integrins: Receptors for extracellular matrix molecules
  Epithelial-Mesenchymal Transition
  Cell Biology of Paracrine Signaling
  Coda
  pt. TWO SPECIFICATION
  Introducing Cell Commitment and Early Embryonic Development
  Levels of Commitment
  Autonomous Specification
  Conditional Specification
  Morphogen Gradients and Conditional Specification
  Syncytial Specification
  Summary
  ch. 4 Fertilization
  Beginning a New Organism
  Structure of the Gametes
  Sperm
  Sperm anatomy
  egg
  Recognition of egg and sperm
  External Fertilization in Sea Urchins
  Sperm attraction: Action at a distance
  acrosome reaction
  Recognition of the egg's extracellular coat
  Fusion of the egg and sperm cell membranes
  One egg, one sperm
  fast block to polyspermy
  slow block to polyspermy
  Calcium as the initiator of the cortical granule reaction
  Activation of Egg Metabolism in Sea Urchins
  Release of intracellular calcium ions
  Sidelights and Speculations Rules of Evidence: "Find It, Lose It, Move It"
  Effects of calcium release
  Fusion of Genetic Material in Sea Urchins
  Internal Fertilization in Mammals
  Getting the gametes into the oviduct: Translocation and capacitation
  In the vicinity of the oocyte: Hyperactivation, thermotaxis, and chemotaxis
  acrosome reaction and recognition at the zona pellucida
  Gamete fusion and the prevention of polyspermy
  Fusion of genetic material
  Activation of the mammalian egg
  Sidelights and Speculations The Nonequivalence of Mammalian Pronuclei
  Coda
  ch. 5 Early Development Rapid Specification in Snails and Nematodes
  Developmental Patterns among the Metazoa
  Sponges and the diploblastic animals
  triploblastic animals: Protostomes and deuterostomes
  Early Developmental Processes: An Overview
  Cleavage
  From fertilization to cleavage
  cytoskeletal mechanisms of mitosis
  Patterns of embryonic cleavage
  Gastrulation and Axis Formation
  Early Development in Snails
  Cleavage in Snail Embryos
  snail fate map
  Autonomous cell specification and the polar lobe
  Sidelights and Speculations Adaptation by Modifying Embryonic Cleavage
  Gastrulation in Snails
  Nematode C. Elegans
  Cleavage and Axis Formation in C. elegans
  Rotational cleavage of the egg
  Anterior-posterior axis formation
  Dorsal-ventral and right-left axis formation
  Control of blastomere identity
  Gastrulation in C. elegans
  ch. 6 Genetics of Axis Specification in Drosophila
  Early Drosophila Development
  Fertilization
  Cleavage
  mid-blastula transition
  Genes That Pattern the Drosophila Body Plan
  Primary Axis Formation during Oogenesis
  Anterior-posterior polarity in the oocyte
  Dorsal-ventral patterning in the oocyte
  Generating the Dorsal-Ventral Pattern in the Embryo
  Dorsal, the ventral morphogen
  Establishing a nuclear Dorsal gradient
  Effects of the Dorsal protein gradient
  Sidelights and Speculations The Left-Right and Inside-Out Axes
  Segmentation and the Anterior-Posterior Body Plan
  Maternal gradients: Polarity regulation by oocyte cytoplasm
  molecular model: Protein gradients in the early embryo
  anterior organizing center: The Bicoid and Hunchback gradients
  terminal gene group
  Summarizing early anterior-posterior axis specification in Drosophila
  Segmentation Genes
  Segments and parasegments
  gap genes
  pair-rule genes
  segment polarity genes
  Homeotic Selector Genes
  Initiating and maintaining the patterns of homeotic gene expression
  Realisator genes
  Axes and Organ Primordia: The Cartesian Coordinate Model
  Coda
  ch. 7 Sea Urchins and Tunicates
  Deuterostome Invertebrates
  Early Development in Sea Urchins
  Sea Urchin Cleavage
  Blastula formation
  Fate maps and the determination of sea urchin blastomeres
  Gene regulatory networks and skeletogenic mesenchyme specification
  Specification of the vegetal cells
  Axis specification
  Sea Urchin Gastrulation
  Ingression of the skeletogenic mesenchyme
  Invagination of the archenteron
  Early Development in Tunicates
  Tunicate Cleavage
  tunicate fate map
  Autonomous and conditional specification of tunicate blastomeres
  Specification of the embryonic axes
  Gastrulation in Tunicates
  Coda
  ch. 8 Early Development in Vertebrates
  Amphibians and Fish
  Early Amphibian Development
  Fertilization, Cortical Rotation, and Cleavage
  Unequal radial holoblastic cleavage
  mid-blastula transition: Preparing for gastrulation
  Amphibian Gastrulation
  Vegetal rotation and the invagination of the bottle cells
  Epiboly of the prospective ectoderm
  Progressive Determination of the Amphibian Axes
  Specification of the germ layers
  dorsal-ventral and anterior-posterior axes
  Work of Hans Spemann and Hilde Mangold
  Autonomous specification versus inductive interactions
  Primary embryonic induction
  Molecular Mechanisms of Amphibian Axis Formation
  How does the organizer form?
  Functions of the organizer
  Induction of neural ectoderm and dorsal mesoderm: BMP inhibitors
  Epidermal inducers: The BMPs
  Sidelights and Speculations BMP4 and Geoffroy's Lobster
  Regional Specificity of Neural Induction
  head inducer: Wnt antagonists
  Trunk patterning: Wnt signals and retinoic acid
  Specifying the Left-Right Axis
  Early Zebrafish Development
  Cleavage
  Gastrulation and Formation of the Germ Layers
  Axis Formation
  Dorsal-ventral axis formation
  fish Nieuwkoop center
  Anterior-posterior axis formation
  Left-right axis formation
  Coda
  ch. 9 Early Development in Vertebrates Birds and Mammals
  Early Development in Birds
  Cleavage
  Gastrulation of the Avian Embryo
  hypoblast
  primitive streak
  Molecular mechanisms of migration through the primitive streak
  Regression of the primitive streak and epiboly of the ectoderm
  Axis Specification and the Avian "Organizer"
  role of gravity and the PMZ
  chick "organizer" and the role of fibroblast growth factors
  Anterior-posterior patterning
  Left-right axis formation
  Early Mammalian Development
  Cleavage
  unique nature of mammalian cleavage
  Contents note continued: Sidelights and Speculations The Decisions That Really Shape Your Life
  Compaction
  Escape from the zona pellucida
  Mammalian Gastrulation
  Modifications for development inside another organism
  Sidelights and Speculations Twins and Chimeras
  Formation of the chorion
  Mammalian Axis Formation
  anterior-posterior axis: Two signaling centers
  Anterior-posterior patterning by FGF and retinoic acid gradients
  Anterior-posterior patterning: The Hox code hypothesis
  dorsal-ventral and left-right axes
  Coda
  pt. THREE STEM CELL CONCEPT
  Introducing Organogenesis
  Stem Cell Concept
  Stem Cell Vocabulary
  Adult Stem Cells
  Stem Cell Niches
  Mesenchymal Stem Cells: Multipotent Adult Stem Cells
  Pluripotent Embryonic Stem Cells
  Stem Cell Therapy
  New Perspective on Organogenesis
  ch. 10 Emergence of the Ectoderm
  Central Nervous System and Epidermis
  Neural Plate and Central Nervous Neural Plate and Central Nervous System
  Formation of the Neural Tube
  Primary neurulation
  Secondary neurulation
  Building the Brain
  anterior-posterior axis
  dorsal-ventral axis
  Differentiation of Neurons in the Brain
  Tissue Architecture of the Central Nervous System
  Neural stem cell differentiation
  Spinal cord and medulla organization
  Cerebellar organization
  Cerebral organization
  Adult Neural Stem Cells
  Sidelights and Speculations The Unique Development of the Human Brain
  Dynamics of Optic Development: The Vertebrate Eye
  Formation of the Eye Field: The Beginnings of the Retina
  Lens-Retina Induction Cascade
  Lens and cornea differentiation
  Neural retina differentiation
  Epidermis and Its Cutaneous Appendages
  Origin of the Epidermis
  Cutaneous Appendages: Mammalian Hair
  Hair follicles and hair generation in mammals
  Adult stem cells and hair regeneration
  Coda
  ch. 11 Neural Crest Cells and Axonal Specificity
  Neural Crest
  Specification of Neural Crest Cells
  Regionalization of the Neural Crest
  Trunk Neural Crest
  Migration pathways of trunk neural crest cells
  Mechanisms of trunk neural crest migration
  ventral pathway
  dorsolateral migration pathway
  Cranial Neural Crest
  Intramembranous ossification: Neural crest-derived head skeleton
  Coordination of face and brain growth
  Tooth formation
  Cardiac Neural Crest
  Cranial Placodes
  Neuron Specification and Axon Specificity
  Sidelights and Speculations The Growth Cone
  Generation of Neuronal Diversity
  Pattern Generation in the Nervous System
  Cell adhesion and contact guidance by attraction and repulsion
  Membrane proteins: The ephrins and semaphorins
  Guidance by diffusible molecules
  Target selection
  Synapse formation: Activity-dependent development
  Differential survival after innervation: The role of neuroptrophins
  Paths to Glory: The Travels of the Retinal Ganglion Axons
  Sidelights and Speculations The Brainbow
  ch. 12 Paraxial and Intermediate Mesoderm
  Paraxial Mesoderm: The Somites and Their Derivatives
  Formation of the Somites
  Where somites form: The Notch pathway
  Separation of somites from the presomitic mesoderm
  Periodicity of somite formation
  Sidelights and Speculations Coordinating Waves and Clocks in Somite Formation
  Epithelialization of the somites
  Specification of the somites along the anterior-posterior axis
  Differentiation of the somites
  Determination of the sclerotome
  Determination of the central dermamyotome
  Determination of the myotome
  Myoblasts and myofibers
  Satellite cells: Unfused muscle progenitor cells
  Osteogenesis: The Development of Bones
  Endochondral ossification
  Vertebrae formation
  Sidelights and Speculations Mechanotransduction in the Musculoskeletal System
  Tendon Formation: The Syndetome
  Formation of the Dorsal Aorta
  Intermediate Mesoderm: The Urogenital System
  Progression of Kidney Types
  Specification of the Intermediate Mesoderm: Pax2/8 and Lim1
  Reciprocal Interactions of Developing Kidney Tissues
  Mechanisms of reciprocal induction
  Coda
  ch. 13 Lateral Plate Mesoderm and the Endoderm
  Formation and Development of the Circulatory System
  Heart Development
  Formation of the heart fields
  Specification of the cardiogenic mesoderm
  Migration of the cardiac precursor cells
  Heart cell differentiation
  Fusion of the heart rudiments and initial heartbeats
  Sidelights and Speculations A Minimalist Heart
  Looping and formation of heart chambers
  Blood Vessel Formation
  Constraints on the construction of blood vessels
  Sidelights and Speculations Redirecting Blood Flow in the Newborn Mammal
  Vasculogenesis: The initial formation of blood vessels
  Angiogenesis: Sprouting of blood vessels and remodeling of vascular beds
  Arterial and venous differentiation
  Organ-specific capillary formation
  Anti-angiogenesis in normal and abnormal development
  lymphatic vessels
  Hematopoiesis: The Stem Cell Concept
  Sites of hematopoiesis
  bone marrow HSC niche
  Hematopoietic inductive microenvironments
  In conclusion
  Endoderm
  Pharynx
  Digestive Tube and Its Derivatives
  Specification of the gut tissue
  Liver, pancreas, and gallbladder
  Sidelights and Speculations Specification of Liver and Pancreas
  Respiratory Tube
  Coda
  ch. 14 Development of the Tetrapod Limb
  Formation of the Limb Bud
  Specification of the limb fields
  Induction of the early limb buds: Wnt proteins and fibroblast growth factors
  Specification of forelimb or hindlimb
  Generating the Proximal-Distal Axis of the Limb
  apical ectodermal ridge
  FGFs in the induction of the AER
  Specifying the limb mesoderm: Determining the proximal-distal polarity of the limb skeleton
  dual-gradient model of limb patterning
  Sidelights and Speculations A Reaction-Diffusion Mechanism for Building the Limb Skeletal Pattern
  Specifying the Anterior-Posterior Axis
  zone of polarizing activity
  Sonic hedgehog defines the ZPA
  Specifying digit identity by Sonic hedgehog
  Sidelights and Speculations Hox Gene Changes during Limb Development
  Generation of the Dorsal-Ventral Axis
  Coordinating the Three Axes
  Cell Death and the Formation of Digits and Joints
  Sculpting the autopod
  Forming the joints
  Sidelights and Speculations Evolution by Altering Limb Signaling Centers
  Continued Limb Growth: Epiphyseal Plates
  Fibroblast growth factor receptors: Dwarfism
  Growth hormone and estrogen receptors
  Parathyroid hormone-related peptide and Indian hedgehog
  Coda
  ch. 15 Sex Determination
  Chromosomal Sex Determination
  Mammalian Pattern
  Primary Sex Determination in Mammals
  developing gonads
  Genetic mechanisms of primary sex determination: Making decisions
  ovary pathway: Wnt4 and R-spondin1
  testis pathway
  right time and the right place
  Secondary Sex Determination in Mammals: Hormonal Regulation of the Sexual Phenotype
  genetic analysis of secondary sex determination
  Chromosomal Sex Determination in Drosophila
  Sidelights and Speculations Brain Sex: Secondary Sex Determination through Multiple Pathways
  Sex-lethal gene
  Doublesex: The switch gene for sex determination
  Brain sex in Drosophila
  Dosage Compensation
  Environmental Sex Determination
  Temperature-Dependent Sex Determination in Reptiles
  aromatase hypothesis for environmental sex determination
  Estrogens, aromatase, sex reversal, and conservation biology
  Location-Dependent Sex Determination
  Coda
  ch. 16 Postembryonic Development
  Metamorphosis, Regeneration, and Aging
  Metamorphosis: The Hormonal Reactivation of Development
  Amphibian Metamorphosis
  Morphological changes associated with amphibian metamorphosis
  Hormonal control of amphibian metamorphosis
  Regionally specific developmental programs
  Sidelights and Speculations Variations on the Theme of Amphibian Metamorphosis
  Metamorphosis in Insects
  Imaginal discs
  Determination of the wing imaginal discs
  Hormonal control of insect metamorphosis
  molecular biology of 20-hydroxyecdysone activity
  Regeneration
  Stem-Cell Mediated Regeneration in Flatworms
  Epimorphic Regeneration of Salamander Limbs
  Formation of the apical ectodermal cap and regeneration blastema
  Proliferation of the blastema cells: The requirement for nerves and the AEC
  Regeneration in Hydra: Morphallaxis and Epimorphosis
  head activator
  head inhibition gradients
  Compensatory Regeneration in the Mammalian Liver
  Aging: The Biology of Senescence
  Genes and Aging
  DNA repair enzymes
  Sidelights and Speculations Exceptions to the Aging Rule
  Aging and the insulin signaling cascade
  mTOR pathway
  Chromatin modification
  Integrating the conserved aging pathways
  Sidelights and Speculations Young Blood: Serum Factors and Progenitor Cells
  Environmental and Epigenetic Causes of Aging
  Promoting Longevity
  ch. 17 Saga of the Germ Line
  Conserved Molecular Components
  Germ Cell Specification
  Germ cell determination in nematodes
  Germ cell determination in insects
  Germ cell determination in frogs and fish
  Germ cell determination in mammals
  inert genome hypothesis
  Sidelights and Speculations Pluripotency, Germ Cells, and Embryonic Stem Cells
  Germ Cell Migration
  Germ cell migration in Drosophila
  Germ cell migration in vertebrates
  Contents note continued: Primacy of Meiosis
  Sidelights and Speculations Big Decisions: Mitosis or Meiosis? Egg or Sperm?
  Gamete Maturation
  Maturation of the oocytes in frogs
  Meroistic oogenesis in insects
  Gametogenesis in Mammals
  Spermatogenesis
  Oogenesis in mammals
  Coda
  pt. FOUR SYSTEMS BIOLOGY
  Expanding Developmental Biology to Medicine, Ecology, and Evolution
  Pragmatic Systems Biology: From Gene to System
  Systems Theory Biology: From System to Gene
  Context-Dependent Properties
  Level-Specific Properties and Emergence
  Heterogeneous Causation
  Integration
  Modules and Robustness
  Homeorhesis
  ch. 18 Birth Defects, Endocrine Disruptors, and Cancer
  Role of Chance
  Genetic Errors of Human Development
  nature of human syndromes
  Genetic and phenotypic heterogeneity
  Teratogenesis: Environmental Assaults on Human Development
  Alcohol as a teratogen
  Retinoic acid as a teratogen
  Other teratogenic agents
  Endocrine Disruptors: The Embryonic Origins of Adult Disease
  Sidelights and Speculations Developmental Origins of Adult-Onset Disease
  DES as an endocrine disruptor
  Sidelights and Speculations Testicular Dysgenesis Syndrome
  Bisphenol A (BPA)
  Endocrine disruptors as obesogens
  Transgenerational Inheritance of Developmental Disorders
  Cancer as a Disease of Development
  Context-dependent tumors
  Cancer stem cells and the epithelial-mesechymal transition
  Cancer and epigenetic gene regulation
  Developmental therapies for cancer
  Coda
  ch. 19 Ecological Developmental Biology
  Biotic, Abiotic, and Symbiotic Regulation of Development
  Environment as a Normal Agent in Producing Phenotypes
  Diet-induced polyphenisms
  Predator-induced polyphenisms
  Temperature as an environmental agent
  Environmental Induction of Behavioral Phenotypes
  Adult anxiety and environmentally regulated DNA methylation
  Learning: The Developmentally Plastic Nervous System
  Experiential changes in mammalian visual pathways
  Life Cycles and Polyphenisms
  Diapause
  Larval settlement
  Sidelights and Speculations Life Cycle Choices: Dictyostelium
  hard life of spadefoot toads
  Developmental Symbioses
  Mechanisms of developmental symbiosis: Getting the partners together
  Euprymna-Vibrio symbiosis
  Obligate developmental mutualism
  Developmental symbiosis in the mammalian intestine
  Coda
  ch. 20 Developmental Mechanisms of Evolutionary Change
  Descent with Modification: Why Animals Are Alike and Different
  Sidelights and Speculations Development, Multicellularity, and the Origin of the Metazoa
  Preconditions for Evolution: The Developmental Structure of the Genome
  Modularity: Divergence through dissociation
  Molecular parsimony: Gene duplication and divergence
  Deep Homology
  Mechanisms of Evolutionary Change
  Heterotopy
  Heterochrony
  Heterometry
  Heterotypy
  Sidelights and Speculations Transposable DNA Elements and the Origins of Pregnancy
  Developmental Constraints on Evolution
  Physical constraints
  Morphogenetic constraints
  Phyletic constraints
  Sidelights and Speculations Reaction-Diffusion Kinetics and the Evolution of Mammalian Teeth
  Selectable Epigenetic Variation
  Genetic assimilation
  Fixation of environmentally induced phenotypes
  Sidelights and Speculations Hsp90 and Genetic Assimilation
  Coda.