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    Chemical Biology of Nucleic Acids Fundamentals and Clinical Applications / edited by Volker A. Erdmann, Wojciech T. Markiewicz, Jan Barciszewski.

    • Title:Chemical Biology of Nucleic Acids Fundamentals and Clinical Applications / edited by Volker A. Erdmann, Wojciech T. Markiewicz, Jan Barciszewski.
    •    
    • Author/Creator:Erdmann, Volker A.
    • Other Contributors/Collections:Markiewicz, Wojciech T.
      Barciszewski, Jan.
      SpringerLink (Online service)
      Springer Nature - Springer Biomedical and Life Sciences eBooks 2014 English International
    • Published/Created:Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
    • In:Springer eBooks
    • Holdings

      • Location:ONLINEWhere is this?
      • Call Number: QD433-436
      • Number of Items:
        0
      • Status:No information available 
       
    • Library of Congress Subjects:Life sciences.
      Human genetics.
      Medicine.
      Nucleic acids.
    • Subject(s):Electronic books.
      Life Sciences.
      Nucleic Acid Chemistry.
      Molecular Medicine.
      Human Genetics.
    • Description:1 online resource
    • Series:RNA Technologies
    • Terms governing use:Access may be restricted to institutions with a site license.
    • Summary:This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.
    • ISBN:9783642544521
      9783642544514
    • Contents:RNA as Major Components in Chemical Evolvable Systems
      How the Early Genetic Code Was Established? - Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems
      Isomerization of RNA Phosphodiester Linkages
      Effects of Ionic Liquid and Liposomes on the Structure, Stability and Function of Nucleic Acids
      Oxidative Damage on RNA Nucleobases
      Use of FRET to Study Dynamics of DNA Replication
      Design, Characterization and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds
      Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies
      Flexible Nucleobase Analogues. Novel Tools for Exploring the Nucleic Acids
      Sequence Selective Recognition of Double-Stranded RNA
      Determining Transient Nucleic Acid Structures by NMR
      Diastereomer-Specific Repertoire of 7'R- or 7'S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physicochemical and Enzymological Properties
      Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms
      Progress in Chemically Modified Nucleic Acid Aptamers
      Aptamers as Molecular Smugglers
      Biochemical Aspects of Subcellular RNA Transport and Localization
      Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications
      Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology
      Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges
      Interaction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression
      Site Directed Spin Labelling of RNA for Distance Measurements by EPR
      Chemo-Enzymatic Strategies to Modify RNA in vitro or in Living Cells
      Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches
      DNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics
      Peptides Targeting G-Quadruplex Structures
      Synthesis of Site-Specifically Modified Long-Mer RNAs
      Synthesis and Exon-Skipping Activity of Chemically-Modified RNAs
      mRNA and snRNA Cap Analogs: Synthesis and Applications
      Innovative Chemistry for Synthesis of Regular RNA, 5'-Triphosphate RNA or 5'-Capped RNA.
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