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    The cell : a molecular approach / Geoffrey M. Cooper, Robert E. Hausman.

    • Title:The cell : a molecular approach / Geoffrey M. Cooper, Robert E. Hausman.
    •    
    • Author/Creator:Cooper, Geoffrey M., author.
    • Other Contributors/Collections:Hausman, Robert E., 1947-2015, author.
    • Published/Created:Sunderland, MA : Sinauer Associates, ©2013.
    • Holdings

       
    • Library of Congress Subjects:Cytology.
      Molecular biology.
      Cells.
    • Medical Subjects: Cells.
      Cell Biology.
      Molecular Biology.
    • Edition:6th ed.
    • Description:xxv, 832 p. : col. ill. ; 29 cm
    • Summary:Designed for use in shorter introductory cellular biology courses, this text presents current comprehensive science in a readable and cohesive text. The sixth edition retains the overall organization, themes, and special features that made the previous edition so popular, but has been updated throughout to reflect major advances in the field. The book offers a wealth of study and review material as well as rich multimedia resources including: quizzes, animations of key concepts and processes, chapter summaries, interactive micrographs and a collection of microscopy showing biological processes in action.
    • Notes:Includes bibliographical references and index.
    • ISBN:9780878939640 (hardcover)
      0878939644 (hardcover)
      1605351555
      9781605351551
    • Contents:Machine generated contents note: pt. I Introduction
      ch. 1 Overview of Cells and Cell Research
      Origin and Evolution of Cells
      first cell
      evolution of metabolism
      Present-day prokaryotes
      Eukaryotic cells
      origin of eukaryotes
      development of multicellular organisms
      Cells as Experimental Models
      E. coli
      Yeasts
      Caenorhabditis elegans
      Drosophila melanogaster
      Arabidopsis thaliana
      Vertebrates
      Tools of Cell Biology
      Light microscopy
      Electron microscopy
      Subcellular fractionation
      Growth of animal cells in culture
      Culture of plant cells
      Viruses
      Key Experiment
      Animal Cell Culture
      Molecular Medicine
      Viruses and Cancer
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 2 Composition of Cells
      Molecules of Cells
      Carbohydrates
      Lipids
      Nucleic acids
      Proteins
      Cell Membranes
      Membrane lipids
      Membrane proteins
      Transport across cell membranes
      Proteomics: Large-Scale Analysis of Cell Proteins
      Identification of cell proteins
      Global analysis of protein localization
      Protein interactions
      Key Experiment
      Folding of Polypeptide Chains
      Key Experiment
      Structure of Cell Membranes
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 3 Cell Metabolism
      Central Role of Enzymes as Biological Catalysts
      catalytic activity of enzymes
      Mechanisms of enzymatic catalysis
      Coenzymes
      Regulation of enzyme activity
      Metabolic Energy
      Free energy and ATP
      generation of ATP from glucose
      derivation of energy from other organic molecules
      Photosynthesis
      Biosynthesis of Cell Constituents
      Carbohydrates
      Lipids
      Proteins
      Nucleic acids
      Key Experiment
      Antimetabolites and Chemotherapy
      Molecular Medicine
      Phenylketonuria
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 4 Fundamentals of Molecular Biology
      Heredity, Genes, and DNA
      Genes and chromosomes
      Genes and enzymes
      Identification of DNA as the genetic material
      structure of DNA
      Replication of DNA
      Expression of Genetic Information
      Colinearity of genes and proteins
      role of messenger RNA
      genetic code
      RNA viruses and reverse transcription
      Recombinant DNA
      Restriction endonucleases
      Generation of recombinant DNA molecules
      Vectors for recombinant DNA
      DNA sequencing
      Expression of cloned genes
      Detection of Nucleic Acids and Proteins
      Amplification of DNA by the polymerase chain reaction
      Nucleic acid hybridization
      Antibodies as probes for proteins
      Gene Function in Eukaryotes
      Genetic analysis in yeasts
      Gene transfer in plants and animals
      Mutagenesis of cloned DNAs
      Introducing mutations into cellular genes
      Interfering with cellular gene expression
      Key Experiment
      DNA Provirus Hypothesis
      Key Experiment
      RNA Interference
      Summary and Key Terms
      Questions
      References and Further Reading
      pt. II Flow of Genetic Information
      ch. 5 Organization and Sequences of Cellular Genomes
      Complexity of Eukaryotic Genomes
      Introns and exons
      Repetitive DNA sequences
      Gene duplication and pseudogenes
      Sequences of Complete Genomes
      genomes of bacteria and yeast
      genomes of Caenorhabditis elegans, Drosophila melanogaster, and other invertebrates
      Plant genomes
      human genome
      genomes of other vertebrates
      Chromosomes and Chromatin
      Chromatin
      Centromeres
      Telomeres
      Bioinformatics and Systems Biology
      Systematic screens of gene function
      Regulation of gene expression
      Variation among individuals and genomic medicine
      Key Experiment
      Discovery of Introns
      Key Experiment
      Human Genome
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 6 Replication, Maintenance, and Rearrangements of Genomic DNA
      DNA Replication
      DNA polymerases
      replication fork
      fidelity of replication
      Origins and the initiation of replication
      Telomeres and telomerase: maintaining the ends of chromosomes
      DNA Repair
      Direct reversal of DNA damage
      Excision repair
      Base-excision repair
      Nucleotide-excision repair
      Transcription-coupled repair
      Mismatch repair
      Translesion DNA synthesis
      Repair of double-strand breaks
      DNA Rearrangements
      Site-specific recombination
      Transposition via DNA intermediates
      Transposition via RNA intermediates
      Gene amplification
      Molecular Medicine
      Colon Cancer and DNA Repair
      Key Experiment
      Rearrangement of Immunoglobulin Genes
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 7 RNA Synthesis and Processing
      Transcription in Prokaryotes
      RNA polymerase and transcription
      Repressors and negative control of transcription
      Positive control of transcription
      Eukaryotic RNA Polymerases and General Transcription Factors
      Eukaryotic RNA polymerases
      General transcription factors and initiation of transcription by RNA polymerase II
      Transcription by RNA polymerases I and III
      Regulation of Transcription in Eukaryotes
      cis-acting regulatory sequences: promoters and enhancers
      Transcription factor binding sites
      Transcriptional regulatory proteins
      Structure and function of transcriptional activators
      Eukaryotic repressors
      Regulation of elongation
      Relationship of chromatin structure to transcription
      Regulation of transcription by noncoding RNAs
      DNA methylation
      RNA Processing and Turnover
      Processing of ribosomal and transfer RNAs
      Processing of mRNA in eukaryotes
      Splicing mechanisms
      Alternative splicing
      RNA editing
      RNA degradation
      Key Experiment
      Isolation of a Eukaryotic Transcription Factor
      Key Experiment
      Discovery of snRNPs
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 8 Protein Synthesis, Processing, and Regulation
      Translation of mRNA
      Transfer RNAs
      ribosome
      organization of mRNAs and the initiation of translation
      process of translation
      Regulation of translation
      Protein Folding and Processing
      Chaperones and protein folding
      Enzymes that catalyze protein folding
      Protein cleavage
      Glycosylation
      Attachment of lipids
      Regulation of Protein Function
      Regulation by small molecules
      Protein phosphorylation and other modifications
      Protein-protein interactions
      Protein Degradation
      ubiquitin-proteasome pathway
      Lysosomal proteolysis
      Key Experiment
      Catalytic Role of Ribosomal RNA
      Key Experiment
      Discovery of Protein-Tyrosine Kinases
      Summary and Key Terms
      Questions
      References and Further Reading
      pt. III Cell Structure and Function
      ch. 9 Nucleus
      Nuclear Envelope and Traffic between the Nucleus and the Cytoplasm
      Structure of the nuclear envelope
      nuclear pore complex
      Selective transport of proteins to and from the nucleus
      Regulation of nuclear protein import
      Transport of RNAs
      Internal Organization of the Nucleus
      Chromosome organization and gene expression
      Sub-compartments within the nucleus
      Nucleolus and rRNA Processing
      Ribosomal RNA genes and the organization of the nucleolus
      Transcription and processing of rRNA
      Ribosome assembly
      Additional functions of the nucleolus
      Molecular Medicine
      Nuclear Lamina Diseases
      Key Experiment
      Identification of Nuclear Localization Signals
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 10 Protein Sorting and Transport
      Endoplasmic Reticulum
      endoplasmic reticulum and protein secretion
      Targeting proteins to the endoplasmic reticulum
      Insertion of proteins into the ER membrane
      Protein folding and processing in the ER
      Quality control in the ER
      smooth ER and lipid synthesis
      Export of proteins and lipids from the ER
      Golgi Apparatus
      Organization of the Golgi
      Protein glycosylation within the Golgi
      Lipid and polysaccharide metabolism in the Golgi
      Protein sorting and export from the Golgi apparatus
      Mechanism of Vesicular Transport
      Experimental approaches to understanding vesicular transport
      Cargo selection, coat proteins, and vesicle budding
      Vesicle fusion
      Lysosomes
      Lysosomal acid hydrolases
      Endocytosis and lysosome formation
      Phagocytosis and autophagy
      Key Experiment
      Signal Hypothesis
      Molecular Medicine
      Gaucher Disease
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 11 Bioenergetics and Metabolism
      Mitochondria
      Organization and function of mitochondria
      genetic system of mitochondria
      Protein import and mitochondrial assembly
      Mechanism of Oxidative Phosphorylation
      electron transport chain
      Chemiosmotic coupling
      Transport of metabolites across the inner membrane
      Chloroplasts and Other Plastids
      structure and function of chloroplasts
      chloroplast genome
      Import and sorting of chloroplast proteins
      Other plastids
      Photosynthesis
      Electron transport
      ATP synthesis
      Peroxisomes
      Functions of peroxisomes
      Peroxisome assembly
      Molecular Medicine
      Diseases of Mitochondria: Leber's Hereditary Optic Neuropathy
      Key Experiment
      Chemiosmotic Theory
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 12 Cytoskeleton and Cell Movement
      Structure and Organization of Actin Filaments
      Contents note continued: Assembly and disassembly of actin filaments
      Organization of actin filaments
      Association of actin filaments with the plasma membrane
      Protrusions of the cell surface
      Actin, Myosin, and Cell Movement
      Muscle contraction
      Contractile assemblies of actin and myosin in nonmuscle cells
      Unconventional myosins
      Formation of protrusions and cell movement
      Microtubules
      Structure and dynamic organization of microtubules
      Assembly of microtubules
      Organization of microtubules within cells
      Microtubule Motors and Movement
      Identification of microtubule motor proteins
      Cargo transport and intracellular organization
      Cilia and flagella
      Reorganization of microtubules during mitosis
      Chromosome movement
      Intermediate Filaments
      Intermediate filament proteins
      Assembly of intermediate filaments
      Intracellular organization of intermediate filaments
      Functions of intermediate filaments: keratins and diseases of the skin
      Key Experiment
      Isolation of Kinesin
      Key Experiment
      Expression of Mutant Keratin Causes Abnormal Skin Development
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 13 Plasma Membrane
      Structure of the Plasma Membrane
      phospholipid bilayer
      Membrane proteins
      Mobility of membrane proteins
      glycocalyx
      Transport of Small Molecules
      Passive diffusion
      Facilitated diffusion and carrier proteins
      Ion channels
      Active transport driven by ATP hydrolysis
      Active transport driven by ion gradients
      Endocytosis
      Phagocytosis
      Receptor-mediated endocytosis
      Protein trafficking in endocytosis
      Molecular Medicine
      Cystic Fibrosis
      Key Experiment
      LDL Receptor
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 14 Cell Walls, the Extracellular Matrix, and Cell Interactions
      Cell Walls
      Bacterial cell walls
      Eukaryotic cell walls
      Extracellular Matrix and Cell-Matrix Interactions
      Matrix structural proteins
      Matrix polysaccharides
      Matrix adhesion proteins
      Cell-matrix interactions
      Cell-Cell Interactions
      Adhesion junctions
      Tight junctions
      Gap junctions
      Plasmodesmata
      Key Experiment
      Characterization of Integrin
      Molecular Medicine
      Gap Junction Diseases
      Summary and Key Terms
      Questions
      References and Further Reading
      pt. IV Cell Regulation
      ch. 15 Cell Signaling
      Signaling Molecules and Their Receptors
      Modes of cell-cell signaling
      Steroid hormones and the nuclear receptor superfamily
      Nitric oxide and carbon monoxide
      Neurotransmitters
      Peptide hormones and growth factors
      Eicosanoids
      Plant hormones
      Functions of Cell Surface Receptors
      G protein-coupled receptors
      Receptor protein-tyrosine kinases
      Cytokine receptors and nonreceptor protein-tyrosine kinases
      Receptors linked to other enzymatic activities
      Pathways of Intracellular Signal Transduction
      cAMP pathway: second messengers and protein phosphorylation
      Cyclic GMP
      Phospholipids and Ca2+
      Pl 3-kinase/Akt and mTOR pathways
      MAP kinase pathways
      JAK/STAT and TGF-β/Smad pathways
      NF-κB signaling
      Hedgehog, Wnt, and Notch pathways
      Signal Transduction and the Cytoskeleton
      Integrins and signal transduction
      Signaling from cell adhesion molecules
      Regulation of the actin cytoskeleton
      Signaling Networks
      Feedback and crosstalk
      Networks of cellular signal transduction
      Key Experiment
      G Protein-Coupled Receptors and Odor Detection
      Molecular Medicine
      Cancer: Signal Transduction and the ras Oncogenes
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 16 Cell Cycle
      Eukaryotic Cell Cycle
      Phases of the cell cycle
      Regulation of the cell cycle by cell growth and extracellular signals
      Cell cycle checkpoints
      Restricting DNA replication to once per cell cycle
      Regulators of Cell Cycle Progression
      Protein kinases and cell cycle regulation
      Families of cyclins and cyclin-dependent kinases
      Growth factors and the regulation of G, Cdk's
      DNA damage checkpoints
      Events of M Phase
      Stages of mitosis
      Entry into mitosis
      spindle assembly checkpoint and progression to anaphase
      Cytokinesis
      Meiosis and Fertilization
      process of meiosis
      Regulation of oocyte meiosis
      Fertilization
      Key Experiment
      Discovery of MPF
      Key Experiment
      Identification of Cyclin
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 17 Cell Death and Cell Renewal
      Programmed Cell Death
      events of apoptosis
      Caspases: the executioners of apoptosis
      Central regulators of apoptosis: the Bcl-2 family
      Signaling pathways that regulate apoptosis
      Alternative pathways of programmed cell death
      Stem Cells and the Maintenance of Adult Tissues
      Proliferation of differentiated cells
      Stem cells
      Medical applications of adult stem cells
      Pluripotent Stem Cells, Cellular Reprogramming, and Regenerative Medicine
      Embryonic stem cells
      Somatic cell nuclear transfer
      Induced pluripotent stem cells
      Transdifferentiation of somatic cells
      Key Experiment
      Identification of Genes Required for Programmed Cell Death
      Key Experiment
      Culture of Embryonic Stem Cells
      Summary and Key Terms
      Questions
      References and Further Reading
      ch. 18 Cancer
      Development and Causes of Cancer
      Types of cancer
      development of cancer
      Causes of cancer
      Properties of cancer cells
      Transformation of cells in culture
      Tumor Viruses
      Hepatitis B and C viruses
      Small DNA tumor viruses
      Herpesviruses
      Retroviruses
      Oncogenes
      Retroviral oncogenes
      Proto-oncogenes
      Oncogenes in human cancer
      Functions of oncogene products
      Tumor Suppressor Genes
      Identification of tumor suppressor genes
      Functions of tumor suppressor gene products
      Roles of oncogenes and tumor suppressor genes in tumor development
      Molecular Approaches to Cancer Treatment
      Prevention and early detection
      Treatment
      Key Experiment
      Discovery of Proto-Oncogenes
      Molecular Medicine
      Imatinib: Cancer Treatment Targeted against the bcr/ab/Oncogene
      Summary and Key Terms
      Questions
      References and Further Reading.
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