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The cell : a molecular approach / Geoffrey M. Cooper, Robert E. Hausman.
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Title:The cell : a molecular approach / Geoffrey M. Cooper, Robert E. Hausman.
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Author/Creator:Cooper, Geoffrey M., author.
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Other Contributors/Collections:Hausman, Robert E., 1947-2015, author.
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Published/Created:Sunderland, MA : Sinauer Associates, ©2013.
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Holdings
Holdings Record Display
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Location:WOODWARD LIBRARY stacksWhere is this?
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Call Number: QH581.2 .C66 2013
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Number of Items:1
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Status:Available
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Location:WOODWARD LIBRARY stacksWhere is this?
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Library of Congress Subjects:Cytology.
Molecular biology.
Cells.
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Medical Subjects: Cells.
Cell Biology.
Molecular Biology.
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Edition:6th ed.
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Description:xxv, 832 p. : col. ill. ; 29 cm
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Summary:Designed for use in shorter introductory cellular biology courses, this text presents current comprehensive science in a readable and cohesive text. The sixth edition retains the overall organization, themes, and special features that made the previous edition so popular, but has been updated throughout to reflect major advances in the field. The book offers a wealth of study and review material as well as rich multimedia resources including: quizzes, animations of key concepts and processes, chapter summaries, interactive micrographs and a collection of microscopy showing biological processes in action.
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Notes:Includes bibliographical references and index.
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ISBN:9780878939640 (hardcover)
0878939644 (hardcover)
1605351555
9781605351551
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Contents:Machine generated contents note: pt. I Introduction
ch. 1 Overview of Cells and Cell Research
Origin and Evolution of Cells
first cell
evolution of metabolism
Present-day prokaryotes
Eukaryotic cells
origin of eukaryotes
development of multicellular organisms
Cells as Experimental Models
E. coli
Yeasts
Caenorhabditis elegans
Drosophila melanogaster
Arabidopsis thaliana
Vertebrates
Tools of Cell Biology
Light microscopy
Electron microscopy
Subcellular fractionation
Growth of animal cells in culture
Culture of plant cells
Viruses
Key Experiment
Animal Cell Culture
Molecular Medicine
Viruses and Cancer
Summary and Key Terms
Questions
References and Further Reading
ch. 2 Composition of Cells
Molecules of Cells
Carbohydrates
Lipids
Nucleic acids
Proteins
Cell Membranes
Membrane lipids
Membrane proteins
Transport across cell membranes
Proteomics: Large-Scale Analysis of Cell Proteins
Identification of cell proteins
Global analysis of protein localization
Protein interactions
Key Experiment
Folding of Polypeptide Chains
Key Experiment
Structure of Cell Membranes
Summary and Key Terms
Questions
References and Further Reading
ch. 3 Cell Metabolism
Central Role of Enzymes as Biological Catalysts
catalytic activity of enzymes
Mechanisms of enzymatic catalysis
Coenzymes
Regulation of enzyme activity
Metabolic Energy
Free energy and ATP
generation of ATP from glucose
derivation of energy from other organic molecules
Photosynthesis
Biosynthesis of Cell Constituents
Carbohydrates
Lipids
Proteins
Nucleic acids
Key Experiment
Antimetabolites and Chemotherapy
Molecular Medicine
Phenylketonuria
Summary and Key Terms
Questions
References and Further Reading
ch. 4 Fundamentals of Molecular Biology
Heredity, Genes, and DNA
Genes and chromosomes
Genes and enzymes
Identification of DNA as the genetic material
structure of DNA
Replication of DNA
Expression of Genetic Information
Colinearity of genes and proteins
role of messenger RNA
genetic code
RNA viruses and reverse transcription
Recombinant DNA
Restriction endonucleases
Generation of recombinant DNA molecules
Vectors for recombinant DNA
DNA sequencing
Expression of cloned genes
Detection of Nucleic Acids and Proteins
Amplification of DNA by the polymerase chain reaction
Nucleic acid hybridization
Antibodies as probes for proteins
Gene Function in Eukaryotes
Genetic analysis in yeasts
Gene transfer in plants and animals
Mutagenesis of cloned DNAs
Introducing mutations into cellular genes
Interfering with cellular gene expression
Key Experiment
DNA Provirus Hypothesis
Key Experiment
RNA Interference
Summary and Key Terms
Questions
References and Further Reading
pt. II Flow of Genetic Information
ch. 5 Organization and Sequences of Cellular Genomes
Complexity of Eukaryotic Genomes
Introns and exons
Repetitive DNA sequences
Gene duplication and pseudogenes
Sequences of Complete Genomes
genomes of bacteria and yeast
genomes of Caenorhabditis elegans, Drosophila melanogaster, and other invertebrates
Plant genomes
human genome
genomes of other vertebrates
Chromosomes and Chromatin
Chromatin
Centromeres
Telomeres
Bioinformatics and Systems Biology
Systematic screens of gene function
Regulation of gene expression
Variation among individuals and genomic medicine
Key Experiment
Discovery of Introns
Key Experiment
Human Genome
Summary and Key Terms
Questions
References and Further Reading
ch. 6 Replication, Maintenance, and Rearrangements of Genomic DNA
DNA Replication
DNA polymerases
replication fork
fidelity of replication
Origins and the initiation of replication
Telomeres and telomerase: maintaining the ends of chromosomes
DNA Repair
Direct reversal of DNA damage
Excision repair
Base-excision repair
Nucleotide-excision repair
Transcription-coupled repair
Mismatch repair
Translesion DNA synthesis
Repair of double-strand breaks
DNA Rearrangements
Site-specific recombination
Transposition via DNA intermediates
Transposition via RNA intermediates
Gene amplification
Molecular Medicine
Colon Cancer and DNA Repair
Key Experiment
Rearrangement of Immunoglobulin Genes
Summary and Key Terms
Questions
References and Further Reading
ch. 7 RNA Synthesis and Processing
Transcription in Prokaryotes
RNA polymerase and transcription
Repressors and negative control of transcription
Positive control of transcription
Eukaryotic RNA Polymerases and General Transcription Factors
Eukaryotic RNA polymerases
General transcription factors and initiation of transcription by RNA polymerase II
Transcription by RNA polymerases I and III
Regulation of Transcription in Eukaryotes
cis-acting regulatory sequences: promoters and enhancers
Transcription factor binding sites
Transcriptional regulatory proteins
Structure and function of transcriptional activators
Eukaryotic repressors
Regulation of elongation
Relationship of chromatin structure to transcription
Regulation of transcription by noncoding RNAs
DNA methylation
RNA Processing and Turnover
Processing of ribosomal and transfer RNAs
Processing of mRNA in eukaryotes
Splicing mechanisms
Alternative splicing
RNA editing
RNA degradation
Key Experiment
Isolation of a Eukaryotic Transcription Factor
Key Experiment
Discovery of snRNPs
Summary and Key Terms
Questions
References and Further Reading
ch. 8 Protein Synthesis, Processing, and Regulation
Translation of mRNA
Transfer RNAs
ribosome
organization of mRNAs and the initiation of translation
process of translation
Regulation of translation
Protein Folding and Processing
Chaperones and protein folding
Enzymes that catalyze protein folding
Protein cleavage
Glycosylation
Attachment of lipids
Regulation of Protein Function
Regulation by small molecules
Protein phosphorylation and other modifications
Protein-protein interactions
Protein Degradation
ubiquitin-proteasome pathway
Lysosomal proteolysis
Key Experiment
Catalytic Role of Ribosomal RNA
Key Experiment
Discovery of Protein-Tyrosine Kinases
Summary and Key Terms
Questions
References and Further Reading
pt. III Cell Structure and Function
ch. 9 Nucleus
Nuclear Envelope and Traffic between the Nucleus and the Cytoplasm
Structure of the nuclear envelope
nuclear pore complex
Selective transport of proteins to and from the nucleus
Regulation of nuclear protein import
Transport of RNAs
Internal Organization of the Nucleus
Chromosome organization and gene expression
Sub-compartments within the nucleus
Nucleolus and rRNA Processing
Ribosomal RNA genes and the organization of the nucleolus
Transcription and processing of rRNA
Ribosome assembly
Additional functions of the nucleolus
Molecular Medicine
Nuclear Lamina Diseases
Key Experiment
Identification of Nuclear Localization Signals
Summary and Key Terms
Questions
References and Further Reading
ch. 10 Protein Sorting and Transport
Endoplasmic Reticulum
endoplasmic reticulum and protein secretion
Targeting proteins to the endoplasmic reticulum
Insertion of proteins into the ER membrane
Protein folding and processing in the ER
Quality control in the ER
smooth ER and lipid synthesis
Export of proteins and lipids from the ER
Golgi Apparatus
Organization of the Golgi
Protein glycosylation within the Golgi
Lipid and polysaccharide metabolism in the Golgi
Protein sorting and export from the Golgi apparatus
Mechanism of Vesicular Transport
Experimental approaches to understanding vesicular transport
Cargo selection, coat proteins, and vesicle budding
Vesicle fusion
Lysosomes
Lysosomal acid hydrolases
Endocytosis and lysosome formation
Phagocytosis and autophagy
Key Experiment
Signal Hypothesis
Molecular Medicine
Gaucher Disease
Summary and Key Terms
Questions
References and Further Reading
ch. 11 Bioenergetics and Metabolism
Mitochondria
Organization and function of mitochondria
genetic system of mitochondria
Protein import and mitochondrial assembly
Mechanism of Oxidative Phosphorylation
electron transport chain
Chemiosmotic coupling
Transport of metabolites across the inner membrane
Chloroplasts and Other Plastids
structure and function of chloroplasts
chloroplast genome
Import and sorting of chloroplast proteins
Other plastids
Photosynthesis
Electron transport
ATP synthesis
Peroxisomes
Functions of peroxisomes
Peroxisome assembly
Molecular Medicine
Diseases of Mitochondria: Leber's Hereditary Optic Neuropathy
Key Experiment
Chemiosmotic Theory
Summary and Key Terms
Questions
References and Further Reading
ch. 12 Cytoskeleton and Cell Movement
Structure and Organization of Actin Filaments
Contents note continued: Assembly and disassembly of actin filaments
Organization of actin filaments
Association of actin filaments with the plasma membrane
Protrusions of the cell surface
Actin, Myosin, and Cell Movement
Muscle contraction
Contractile assemblies of actin and myosin in nonmuscle cells
Unconventional myosins
Formation of protrusions and cell movement
Microtubules
Structure and dynamic organization of microtubules
Assembly of microtubules
Organization of microtubules within cells
Microtubule Motors and Movement
Identification of microtubule motor proteins
Cargo transport and intracellular organization
Cilia and flagella
Reorganization of microtubules during mitosis
Chromosome movement
Intermediate Filaments
Intermediate filament proteins
Assembly of intermediate filaments
Intracellular organization of intermediate filaments
Functions of intermediate filaments: keratins and diseases of the skin
Key Experiment
Isolation of Kinesin
Key Experiment
Expression of Mutant Keratin Causes Abnormal Skin Development
Summary and Key Terms
Questions
References and Further Reading
ch. 13 Plasma Membrane
Structure of the Plasma Membrane
phospholipid bilayer
Membrane proteins
Mobility of membrane proteins
glycocalyx
Transport of Small Molecules
Passive diffusion
Facilitated diffusion and carrier proteins
Ion channels
Active transport driven by ATP hydrolysis
Active transport driven by ion gradients
Endocytosis
Phagocytosis
Receptor-mediated endocytosis
Protein trafficking in endocytosis
Molecular Medicine
Cystic Fibrosis
Key Experiment
LDL Receptor
Summary and Key Terms
Questions
References and Further Reading
ch. 14 Cell Walls, the Extracellular Matrix, and Cell Interactions
Cell Walls
Bacterial cell walls
Eukaryotic cell walls
Extracellular Matrix and Cell-Matrix Interactions
Matrix structural proteins
Matrix polysaccharides
Matrix adhesion proteins
Cell-matrix interactions
Cell-Cell Interactions
Adhesion junctions
Tight junctions
Gap junctions
Plasmodesmata
Key Experiment
Characterization of Integrin
Molecular Medicine
Gap Junction Diseases
Summary and Key Terms
Questions
References and Further Reading
pt. IV Cell Regulation
ch. 15 Cell Signaling
Signaling Molecules and Their Receptors
Modes of cell-cell signaling
Steroid hormones and the nuclear receptor superfamily
Nitric oxide and carbon monoxide
Neurotransmitters
Peptide hormones and growth factors
Eicosanoids
Plant hormones
Functions of Cell Surface Receptors
G protein-coupled receptors
Receptor protein-tyrosine kinases
Cytokine receptors and nonreceptor protein-tyrosine kinases
Receptors linked to other enzymatic activities
Pathways of Intracellular Signal Transduction
cAMP pathway: second messengers and protein phosphorylation
Cyclic GMP
Phospholipids and Ca2+
Pl 3-kinase/Akt and mTOR pathways
MAP kinase pathways
JAK/STAT and TGF-β/Smad pathways
NF-κB signaling
Hedgehog, Wnt, and Notch pathways
Signal Transduction and the Cytoskeleton
Integrins and signal transduction
Signaling from cell adhesion molecules
Regulation of the actin cytoskeleton
Signaling Networks
Feedback and crosstalk
Networks of cellular signal transduction
Key Experiment
G Protein-Coupled Receptors and Odor Detection
Molecular Medicine
Cancer: Signal Transduction and the ras Oncogenes
Summary and Key Terms
Questions
References and Further Reading
ch. 16 Cell Cycle
Eukaryotic Cell Cycle
Phases of the cell cycle
Regulation of the cell cycle by cell growth and extracellular signals
Cell cycle checkpoints
Restricting DNA replication to once per cell cycle
Regulators of Cell Cycle Progression
Protein kinases and cell cycle regulation
Families of cyclins and cyclin-dependent kinases
Growth factors and the regulation of G, Cdk's
DNA damage checkpoints
Events of M Phase
Stages of mitosis
Entry into mitosis
spindle assembly checkpoint and progression to anaphase
Cytokinesis
Meiosis and Fertilization
process of meiosis
Regulation of oocyte meiosis
Fertilization
Key Experiment
Discovery of MPF
Key Experiment
Identification of Cyclin
Summary and Key Terms
Questions
References and Further Reading
ch. 17 Cell Death and Cell Renewal
Programmed Cell Death
events of apoptosis
Caspases: the executioners of apoptosis
Central regulators of apoptosis: the Bcl-2 family
Signaling pathways that regulate apoptosis
Alternative pathways of programmed cell death
Stem Cells and the Maintenance of Adult Tissues
Proliferation of differentiated cells
Stem cells
Medical applications of adult stem cells
Pluripotent Stem Cells, Cellular Reprogramming, and Regenerative Medicine
Embryonic stem cells
Somatic cell nuclear transfer
Induced pluripotent stem cells
Transdifferentiation of somatic cells
Key Experiment
Identification of Genes Required for Programmed Cell Death
Key Experiment
Culture of Embryonic Stem Cells
Summary and Key Terms
Questions
References and Further Reading
ch. 18 Cancer
Development and Causes of Cancer
Types of cancer
development of cancer
Causes of cancer
Properties of cancer cells
Transformation of cells in culture
Tumor Viruses
Hepatitis B and C viruses
Small DNA tumor viruses
Herpesviruses
Retroviruses
Oncogenes
Retroviral oncogenes
Proto-oncogenes
Oncogenes in human cancer
Functions of oncogene products
Tumor Suppressor Genes
Identification of tumor suppressor genes
Functions of tumor suppressor gene products
Roles of oncogenes and tumor suppressor genes in tumor development
Molecular Approaches to Cancer Treatment
Prevention and early detection
Treatment
Key Experiment
Discovery of Proto-Oncogenes
Molecular Medicine
Imatinib: Cancer Treatment Targeted against the bcr/ab/Oncogene
Summary and Key Terms
Questions
References and Further Reading.