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    Advances and recent applications in LC-MS and HPLC / Quazi Syed Azharuddin [and seven others].

    • Title:Advances and recent applications in LC-MS and HPLC / Quazi Syed Azharuddin [and seven others].
    •    
    • Author/Creator:Azharuddin, Quazi Syed, author.
    • Published/Created:Amsterdam : Elsevier, [2015]
    • Holdings

       
    • Library of Congress Subjects:Liquid chromatography.
      Mass spectrometry.
    • Medical Subjects: Chromatography, Liquid--methods.
    • Description:vii, 86 pages ; 23 cm
    • Notes:Includes bibliographical references.
    • ISBN:9780128042076 paperback
      0128042079 paperback
    • Contents:Machine generated contents note: ch. 1 Introduction: Liquid Chromatography/Mass Spectrometry
      Definitions
      Fundamentals of LC/MS
      Application of LC/MS
      ch. 2 Construction of High-Performance Liquid Chromatography
      Construction of the HPLC System
      Microcomponents of HPLC
      Tubing and Design of HPLC
      ch. 3 Advances and Recent Applications in LC/MS
      Determination of Lipophilicity in Preservative Drugs
      Preservative Drugs: Methylparaben
      Detection of Compounds
      Study of Complex Biologic Molecules
      Identification of Impurities and Metabolites
      Analysis of Flammable Materials
      Study of Toxicology and Drugs
      Analysis of Clinical Drugs
      Analysis of Pesticides
      ch. 4 Column and Distribution Modes
      Stainless Steel Columns
      Column Packing Substance
      Selectivity in Normal Phase
      Bonded-Phase Silica
      Effect of the Mobile Phase
      Optimizing Separation of Ionic and Nonionic Reversed Phase
      Zirconium Packing Separation Mode Columns
      Polymeric Bonded-Phase Columns
      Ion-Exchange Columns
      ch. 5 Column Safety Procedures in HPLC
      Safety Procedures in HPLC
      Injector Along with Pipe Washing
      Gradient Routine Checking
      Water with Solvent Cleanup
      Silica Column Cleanup
      Zirconium Column Cleaning
      Polymeric Column Safety
      ch. 6 Solution Preparation
      Preparation Solvent of HPLC
      Controlling the Selectivity of pH
      Solution Preparation
      Cartridge Column Cleaning
      Effect of Concentration
      Development of Isocratic and Gradient Elution
      Computer-Assisted Development
      ch. 7 Basic Components LC/MS
      Ionization Source
      Analyzer with Ion Detector Development
      Vacuum Pumps
      Peak Detection
      ch. 8 Solvent Removal Process for Liquid Chromatography and the Mass Spectrometer
      Elution Solvent and Ionization
      Atmospheric Pressure Ionization Interfaces
      ES Ionization Interface
      IS Interface
      ch. 9 Mass Analyzer Instrumentation Technique
      Quadrupole
      Mass Spectrometers Analyzers Instrument
      Mass Spectrometers Ion Trap Analyzer
      Time of Flight (TOF)
      Fourier Transform Mass Spectrometry (FT-MS)
      ch. 10 Mass Spectrometer Operating Procedure
      Mass Spectrometer Vacuum Pump
      MS Vacuum Analysis
      Pump Servicing
      Mass Spectrometer Operating Process
      Mass Spectrophotometer Calibration
      Instrumentation Cleaning Process
      ch. 11 Proteins Analysis and LC/MS
      Determination of Protein Molecular Weight
      Protein Study by Two-Dimensional GEP
      Analysis of Peptide Structures
      Transient Peptides and Buildup Proteins.
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