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    Immunology : a short course / Richard Coico, Geoffrey Sunshine.

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    • Title:Immunology : a short course / Richard Coico, Geoffrey Sunshine.
    •    
    • Author/Creator:Coico, Richard, author.
    • Other Contributors/Collections:Sunshine, Geoffrey, author.
    • Published/Created:Chichester, West Sussex, UK ; Hoboken, NJ : John Wiley & Sons Ltd, 2015.

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    • Library of Congress Subjects:Immunology.
    • Medical Subjects: Allergy and Immunology.
      Immune System Diseases.
      Immune System Processes.
      Immunity.
    • Edition:Seventh edition.
    • Description:xxiii, 406 pages ; 28 cm
    • Summary:Immunology: A Short Course, Seventh Edition introduces allthe critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs.
    • Notes:Includes bibliographical references and index.
    • ISBN:9781118396919 (paperback)
      111839691X (paperback)
    • Contents:Machine generated contents note: Introduction,
      Innate and Adaptive Immunity,
      Innate Immunity,
      Adaptive Immunity,
      Clonal Selection Theory,
      Active, Passive, and Adoptive Immunization,
      Major Characteristics of the Adaptive Immune Response,
      Cells Involved in the Adaptive Immune Response,
      Humoral and Cellular Immunity,
      Humoral Immunity,
      Cell-Mediated Immunity,
      Generation of Diversity in the Immune Response,
      Benefits of Immunology,
      Damaging Effects of the Immune Response,
      Future of Immunology,
      Short Course Begins Here,
      References and Bibliography
      Introduction,
      Physical and Chemical Barriers of Innate Immunity,
      Origin, Differentiation, and Characterization of Cells of the Innate Immune System,
      Pattern Recognition: The Hallmark of Innate Immune Responses,
      Pattern Recognition Receptors,
      Complement,
      Intracellular and Extracellular Killing of Microorganisms,
      Inflammation,
      Hallmark Signs of Inflammation,
      Localized Inflammatory Responses,
      Chronic Inflammation,
      Fever,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Cells and Organs Involved in Adaptive Immunity,
      Lymphatic Organs,
      Lymphocyte Migration and Recirculation,
      Fate of Antigen after Penetration,
      Frequency of Antigen-Specific Naïve Lymphocytes,
      Interrelationship between Innate and Adaptive Immunity,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Requirements for Immunogenicity,
      Foreignness,
      High Molecular Weight,
      Chemical Complexity,
      Degradability,
      Haptens,
      Further Requirements for Immunogenicity,
      Primary and Secondary Responses,
      Antigenicity and Antigen-Binding Site,
      Epitopes Recognized by B Cells and T Cells,
      Major Classes of Antigens,
      Binding of Antigen with Antigen-Specific Antibodies or T Cells,
      Cross-Reactivity,
      Adjuvants,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Isolation and Characterization of Immunoglobulins,
      Structure of Light and Heavy Chains,
      Domains,
      Hinge Region,
      Variable Region,
      Immunoglobulin Variants,
      Isotypes,
      Allotypes,
      Idiotypes,
      Structural Features of IgG,
      Biologic Properties of IgG,
      Agglutination and Formation of Precipitate,
      Passage through the Placenta and Absorption in Neonates,
      Opsonization,
      Antibody-Dependent Cell-Mediated Cytotoxicity,
      Activation of Complement,
      Neutralization of Toxins,
      Immobilization of Bacteria,
      Neutralization of Viruses,
      Structural Features of IgM,
      Biologic Properties of IgM,
      Complement Fixation,
      Neonatal Immunity and First Line of Humoral Defense,
      Agglutination,
      Isohemagglutinins,
      Structural and Biologic Properties of IgA,
      Biologic Properties of IgA,
      Role in Mucosal Infections,
      Bactericidal Activity,
      Antiviral Activity,
      Structural and Biologic Properties of IgD,
      Structural and Biologic Properties of IgE,
      Importance of IgE in Parasitic Infections and Hypersensitivity Reactions,
      Kinetics of the Antibody Response Following Immunization,
      Primary Response,
      Secondary Response,
      Immunoglobulin Superfamily,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Antigen-Antibody Interactions,
      Primary Interactions between Antibody and Antigen,
      Association Constant,
      Affinity and Avidity,
      Secondary Interactions between Antibody and Antigen,
      Agglutination Reactions,
      Precipitation Reactions,
      Immunoassays,
      Direct-Binding Immunoassays,
      Solid-Phase Immunoassays,
      Immunofluorescence,
      Direct Immunofluorescence,
      Indirect Immunofluorescence,
      Flow Cytometry,
      Immunoabsorption and Immunoadsorption,
      Cellular Assays,
      Assays of Lymphocyte Function,
      B-Cell and T-Cell Proliferation Assays,
      Antibody Production by B Cells,
      Effector Cell Assays for T Cells and Natural Killer Cells,
      Cell Culture,
      Primary Cell Cultures and Cloned Lymphoid Cell Lines,
      B-Cell Hybridomas and Monoclonal Antibodies,
      T-Cell Hybridomas,
      Genetically Engineered Molecules and Receptors,
      Experimental Animal Models,
      Inbred Strains,
      Adoptive Transfer,
      SCID Mice,
      Thymectomized and Congenitally Athymic (Nude) Mice,
      Transgenic Mice and Gene Targeting,
      Transgenic Mice,
      Knockout and Knock-in Mice,
      Analysis of Gene Expression,
      Microarrays to Assess Gene Expression,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Brief Review of Nonimmunoglobulin Gene Structure and Gene Expression,
      Genetic Events in Synthesis of Ig Chains,
      Organization and Rearrangement of Light-Chain Genes,
      K-Chain Synthesis,
      λ-Chain Synthesis,
      Organization and Rearrangement of Heavy-Chain Genes,
      Allelic Exclusion and the Regulation of Ig Gene Expression,
      Class or Isotype Switching,
      Generation of Antibody Diversity,
      Presence of Multiple V Genes in the Germline,
      VJ and VDJ Combinatorial Association,
      Random Assortment of H and L Chains,
      Junctional Diversity,
      Somatic Hypermutation,
      Somatic Gene Conversion,
      Role of Activation-Induced Cytidine Deaminase in Generating Antibody Diversity,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Development of B Lymphocytes,
      Overview,
      Sites of Early B-Cell Differentiation,
      Pro-B and Pre-B Cells: First Ig Rearrangements,
      Immature B Cells,
      Transitional B cells,
      Mature B Cells,
      Plasma Cells,
      Memory B Cells,
      Sites of Antibody Synthesis,
      Interaction of Antigen, B Cells, and Helper T Cells in the Lymph Node,
      Events in the Germinal Center,
      Antibody Synthesis in Mucosal Tissue,
      Thymus-Independent Antibody Responses,
      B-Cell Membrane Proteins,
      Stage-Specific Markers,
      Antigen-Binding Molecules: Membrane Immunoglobulin,
      Signal Transduction Molecules Associated with Membrane Immunoglobulin,
      Molecules Involved in T-B Cell Interactions,
      Homing,
      Intracellular Signaling in B Cells,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      How the MHC Got Its Name,
      MHC Role in Antigen Presentation,
      Different MHC Molecules Are Expressed by Distinct Host Cells and Interact with Different Sets of T Cells,
      MHC Class I,
      MHC Class II,
      Variability of MHC Class I and MHC Class II Molecules,
      Structure of MHC Class I and Class II Molecules,
      MHC Class I,
      Structure of MHC Class II Molecules,
      Antigen Processing and Presentation: How MHC Molecules Bind Peptides and Create Ligands That Interact with T Cells,
      Exogenous Antigens and Generation of MHC Class II-Peptide Complexes,
      Endogenous Antigens: Generation of MHC Class I-Peptide Complexes,
      Cross-Presentation: Exogenous Antigens Presented in the MHC Class I Pathway,
      Which Antigens Trigger Which T-Cell Responses?,
      MHC Molecules Bind Peptides Derived from Self-Molecules,
      Inability to Respond to an Antigen,
      Other Types of Antigen That Activate T-Cell Responses,
      Superantigens,
      Lipids and Glycolipids,
      Multiple Antigens Activate γδ Cells,
      Genes of the HLA Region,
      Nomenclature of Polymorphic MHC Molecules,
      Regulation of Expression of MHC Genes,
      Codominant Expression,
      Coordinate Regulation,
      Inheritance of MHC Genes,
      MHC in Other Species,
      Diversity of MHC Molecules: MHC Association with Resistance and Susceptibility to Disease,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Antigen-Specific T-Cell Receptor,
      Molecules That Interact with Antigen,
      T-Cell Receptor Complex,
      Co-Receptors,
      Other Important Molecules Expressed on the T-Cell Surface,
      γδ T Cells,
      Genes Coding for T-Cell Receptors,
      Generation of T-Cell Receptor Diversity,
      T-Cell Differentiation in the Thymus,
      Thymus as Primary Organ for T-Cell Differentiation,
      Key Steps in Thymic Differentiation,
      Early T-Cell Receptor Gene Rearrangements: Double-Negative Cells and Splitting Off of γδ T Cells,
      Pre-T Cells,
      Double-Positive Cells,
      Thymic Selection,
      Leaving the Thymus,
      Generation of the T-Cell Repertoire,
      Characteristics of o
      T Cells Emerging from the Thymus,
      Further Differentiation of CD4+ and CD8+ T Cells Outside the Thymus,
      Differentiation of Other Cell Types in the Thymus,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Two-Signal Model for the Activation of T Cells,
      Dendritic Cells Are the Key APC for Naïve T Cells,
      Activation of CD4+ T Cells,
      Paired Interactions at the Surface of the APC and CD4+ T Cell,
      Intracellular Events in CD4+ T-Cell Activation,
      Differentiation to Effector Cells and Migration Out of the Lymph Node,
      Termination of the Response,
      Other Ways to Activate CD4+ T Cells,
      CD4+ T-Cell Function,
      Cytokine Synthesis,
      Major Subsets of Cytokine-Producing CD4+ T Cells,
      Cross-Inhibition of CD4+ T-Cell Subsets,
      Other Sets of Cytokine-Producing CD4+ T Cells,
      Further Points on Cytokine Synthesis,
      Help for B Cell in the Response to TD Antigens,
      Events in the Germinal Center,
      Linked Recognition,
      Activation and Function of CD8+ T Cells,
      Generation of Effector CD8+ T Cells,
      Contents note continued: CD8+ T-Cell Killing of Target Cells,
      MHC Restriction and CD8+ T Cell Killer Function,
      Memory T Cells,
      Function of Other Subsets of T Cells,
      NKT Cells,
      γδ T Cells,
      Innate Lymphoid Cells,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      History of Cytokines,
      Pleiotropic and Redundant Properties of Cytokines,
      General Properties of Cytokines,
      Common Functional Properties,
      Common Systemic Activities,
      Common Cell Sources and Cascading Events,
      Functional Categories of Cytokines,
      Cytokines That Facilitate Innate Immune Responses,
      Cytokines That Regulate Adaptive Immune Responses,
      Cytokines That Induce Differentiation of Distinct T-Cell Lineages,
      Cytokines That Inhibit Lineage-Specific T-Cell Differentiation,
      Cytokines That Promote Inflammatory Responses,
      Cytokines That Affect Leukocyte Movement,
      Cytokines That Stimulate Hematopoiesis,
      Cytokine Receptors,
      Cytokine Receptor Families,
      Common Cytokine Receptor Chains,
      Cytokine Receptor-Mediated Signal Transduction,
      Role of Cytokines and Cytokine Receptors in Disease,
      Toxic Shock Syndrome,
      Bacterial Septic Shock,
      Cancers,
      Autoimmunity and Other Immune-Based Diseases,
      Therapeutic Exploitation of Cytokines and Cytokine Receptors,
      Cytokine Inhibitors/Antagonists,
      Reversing Cellular Deficiencies,
      Treatment of Immunodeficiencies,
      Treatment of Patients with Cancer, Transplanted Organs, and Tissues, and Viral Infections,
      Treatment of Allergies and Asthma,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Central Tolerance,
      Mechanisms of Central Tolerance: T and B Cells,
      Mechanisms of Central Tolerance: B Cells,
      Peripheral Tolerance,
      Anergy,
      Regulatory T Cells,
      Fas-FasL Interactions,
      Oral Tolerance,
      Immune Privilege,
      Autoimmunity and Disease,
      Genetic Susceptibility,
      Environmental Susceptibility,
      Drug and Hormonal Triggers of Autoimmunity,
      Autoimmune Diseases,
      Autoimmune Diseases in Which Antibodies Play a Predominant Role in Mediating Organ Damage,
      Autoimmune Diseases in Which T Cells Play a Predominant Role in Organ Damage,
      Therapeutic Strategies,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Overview of Complement Activation,
      Classical Pathway,
      Lectin Pathway,
      Alternative Pathway,
      Steps Shared by All Pathways: Activation of C3 and C5,
      Terminal Pathway,
      Regulation of Complement Activity,
      Biologic Activities of Complement,
      Production of Opsonins,
      Production of Anaphylatoxins,
      Lysis,
      Other Important Complement Functions,
      Complement Deficiencies,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Hypersensitivity,
      Coombs-Gell Hypersensitivity Designations,
      General Characteristics of Allergic Reactions,
      Sensitization Phase,
      TH2 Cell Dependency of IgE Antibody Production,
      Activation Phase,
      Effector Phase,
      Preformed Mediators,
      Newly Synthesized Mediators,
      Late-Phase Reaction,
      Clinical Aspects of Allergic Reactions,
      Allergic Rhinitis,
      Food Allergies,
      Atopic Dermatitis,
      Asthma,
      Clinical Tests for Allergies and Clinical Intervention,
      Detection,
      Intervention,
      Protective Role of IgE,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Type II Hypersensitivity,
      Complement-Mediated Reactions,
      Antibody-Dependent Cell-Mediated Cytotoxicity,
      Antibody-Mediated Cellular Dysfunction,
      Examples of Type II Hypersensitivity Reactions,
      Transfusion Reactions,
      Drug-Induced Reactions,
      Rhesus Incompatibility Reactions,
      Reactions Involving Cell Membrane Receptors,
      Reactions Involving Other Cell Membrane Determinants,
      Type III Hypersensitivity,
      Systemic Immune Complex Disease,
      Localized Immune Complex Disease,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions
      Introduction,
      General Characteristics and Pathophysiology of DTH,
      Mechanisms Involved in DTH,
      Examples of DTH,
      Contact Sensitivity,
      Granulomatous Hypersensitivity,
      Tuberculin-Type Hypersensitivity,
      Allograft Rejection,
      Additional Examples of DTH,
      Treatment of DTH,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Immunodeficiency Syndromes,
      Primary Immunodeficiency Syndromes,
      Immunodeficiency Disorders Associated with T Cells and Cell-Mediated Immunity,
      B-Cell-Associated or Immunoglobulin-Associated Immunodeficiency Disorders,
      Disorders of T-B Interactions,
      Phagocytic Dysfunctions,
      Natural Killer Cell Deficiency,
      Diseases Caused by Abnormalities in the Complement System,
      Secondary Immunodeficiency Diseases,
      Acquired Immunodeficiency Syndrome,
      Initial Description and Epidemiology,
      Human Immunodeficiency Virus,
      Clinical Course,
      Prevention, Control, Diagnosis, and Therapy of HIV Infection,
      Neoplasms of Lymphoid System,
      B-Cell Neoplasms,
      Mature B-Cell Neoplasms,
      Plasma Cell Neoplasms,
      T-Cell Neoplasms,
      Mature T-Cell Neoplasms,
      Immunotherapy,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Relationship between Donor and Recipient,
      Immune Mechanisms Are Responsible for Allograft Rejection,
      Categories of Allograft Rejection,
      Hyperacute Rejection,
      Acute Rejection,
      Chronic Rejection,
      Role of MHC Molecules in Allograft Rejection,
      Mechanisms of Alloantigen Recognition by T Cells,
      Role of T Cell Lineages and Cytokines in Allograft Rejection,
      Laboratory Tests Used in Tissue Typing,
      Prolongation of Allograft Survival: Immunosuppresive Therapy,
      Anti-Inflammatory Agents,
      Cytotoxic Drugs,
      Agents That Interfere with Cytokine Production and Signaling,
      Immunosuppressive Antibody Therapy,
      New Immunosuppressive Strategies and Frontiers,
      Hematopoietic Stem Cell Transplantation,
      Graft-versus-Host Disease,
      Xenogeneic Transplantation,
      Fetus: A Tolerated Allograft,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Tumor Antigens,
      Categories of Tumor Antigens,
      Normal Cellular Gene Products,
      Mutant Cellular Gene Products,
      Tumor Antigens Encoded by Oncogenes,
      Immunologic Factors Influencing the Incidence of Cancer,
      Effector Mechanisms in Tumor Immunity,
      B-Cell Responses to Tumors,
      Destruction of Tumor Cells by Opsonization and Phagocytosis,
      Antibody-Mediated Loss of Adhesive Properties of Tumor Cells,
      Cell-Mediated Responses to Tumor Cells,
      Destruction of Tumor Cells by T Lymphocytes,
      Antibody-Dependent Cell-Mediated Cytotoxicity,
      Destruction of Tumor by NK Cells, NIC/T Cells, and Cytokine-Activated Killer Cells,
      Destruction of Tumor Cells by Activated Macrophages and Neutrophils,
      Cytokines,
      Limitations of the Effectiveness of the Immune Response against Tumors,
      Immunodiagnosis,
      Detection of Myeloma Proteins Produced by Plasma Cell Tumors,
      Detection of α-Fetoprotein,
      Carcinoembryonic Antigen,
      Detection of Prostate-Specific Antigen,
      Cancer Antigen-125,
      Tumor Immunoprophylaxis,
      Immunotherapy,
      Other Immunotherapeutic Strategies in Cancer,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,
      Introduction,
      Host Defense against the Various Classes of Microbial Pathogens,
      Immunity to Viruses,
      Immunity to Bacteria,
      Immunity to Parasites,
      Immunity to Fungi,
      Mechanisms by Which Pathogens Evade the Immune Response,
      Encapsulated Bacteria,
      Toxins,
      Superantigens,
      Antigenic Variation,
      Intracellular Survival,
      Suppression of the Immune System,
      Extracellular Enzymes,
      Expression of Antibody-Binding Proteins,
      Principles of Immunization,
      Objectives of Immunization,
      Active Immunizations,
      Recommended Immunizations,
      Use of Vaccines in Selected Populations,
      Basic Mechanisms of Protection,
      Significance of the Primary and Secondary Responses,
      Age and Timing of Immunizations,
      Vaccine Precautions,
      Site of Administration of Antigen,
      Hazards,
      Recent Approaches to Production of Vaccines,
      Vaccines Produced by Recombinant DNA,
      Conjugated Polysaccharides,
      Synthetic Peptide Vaccines,
      Virus-Carrier Vaccine,
      Bacterium-Carrier Vaccine,
      DNA Vaccines,
      Toxoids,
      Passive Immunization,
      Passive Immunization through Placental Antibody Transfer,
      Passive Immunization via Colostrum,
      Passive Antibody Therapy and Serum Therapy,
      Monoclonal and Polyclonal Preparations,
      Preparation and Properties of Human Immune Serum Globulin,
      Indications for the Use of Immune Globulin,
      Precautions on the Uses of Human Immune Serum Globulin Therapy,
      Colony-Stimulating Factors,
      References and Bibliography,
      Review Questions,
      Answers to Review Questions,.
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