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• Title:Signal transduction / Ijsbrand M. Kramer.
  
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• Author/Creator:Kramer, Ijsbrand M., author.
  
• Published/Created:London, UK ; San Diego, CA, USA : Academic Press is an imprint of Elsevier, [2016]
  ©2016
  

• Holdings

  Holdings Record Display

  • Location:WOODWARD LIBRARY stacksWhere is this?
    
  • Call Number: QP517.C45 K76 2016
    
  • Number of Items:1
    
  • Status:Available
    

   
• Library of Congress Subjects:Cellular signal transduction.
  
• Medical Subjects: Signal Transduction.
  
• Edition:Third edition.
  
• Description:xlv, 1, 078 pages : illustrations (some color) ; 24 cm
  
• Summary:"A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and adhesion molecules. In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor -ligand interactions to post-translational modifications operational in the process of bringing about cellular changes. The phosphorylation process, from bacteria to men, is discussed in detail. Signal transduction third edition further elaborates on diverse signaling cascades within particular contexts such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite, oncogenic transformation and cell fate decision during development or in stem cell niches. The subjects have been enriched with descriptions of the relevant anatomical, histological, physiological or pathological condition."--Page 4 of cover.
  
• Notes:Revision of: Signal transduction / Bastien D. Gomperts, Peter E.R. Tatham, IJsbrand M. Kramer. c2002.
  Includes bibliographical references and index.
  
• ISBN:9780123948038 hardcover
  0123948037 hardcover
  9780123948199 electronic book
  
• Contents:Machine generated contents note: Irritability, a vital phenomenon
  Protoendocrinologists
  Hormones and neurotransmitters
  receptive substance
  Proto-messengers and receptors
  Growth factors: setting the framework
  Problems with nomenclature
  References
  First messengers
  First-messenger signals are ambiguous: their meaning is embedded in context
  plasma membrane barrier, membrane receptors, and signal transduction
  Receptors and their ligands
  Signaling mechanisms
  Wired allostery and thoughtful decisions
  Posttranslational modifications involved in signaling events
  Focus on nucleotide exchange
  brief definition of effectors
  Focus on protein phosphorylation
  Protein kinases catalyze the phosphate transfer
  Protein domains, their folds, and their graphic representations
  Which amino acids are susceptible to phosphorylation?
  Bacterial exceptions: phosphoenolpyruvate as phosphate donor and histidine kinases as environmental sensors
  Substrate phosphorylation motifs and distal docking sites
  Protein kinase activation mechanisms
  Protein phosphatases
  PPP1R12A (MYPT1) as an example of how a regulatory subunit controls substrate selectivity (of PP1CC)
  Regulation by intramolecular domain interaction, the example of PTPN6 (SHP-1)
  Decision-making in glycogen synthesis and breakdown: concerted action of kinases and phosphatases
  Signal termination
  References
  α- and β-adrenoceptors
  Adrenaline-binding and G-protein-coupling mechanisms
  Adrenoceptor agonists, antagonists, and inverse agonists
  How do ligand-binding characteristics translate into signaling effects?
  Adenylyl cyclase
  cAMP-binding proteins
  Phospholipase C
  Muscle contraction: striated versus smooth muscle
  Contraction waves in the heart
  Adrenaline as a cardiac ino- and chronotrope messenger
  Arresting the β-adrenoreceptor signal: pathway switching and the role of G-protein receptor kinase and arrestin
  α1-adrenoceptors and visceral vasoconstriction
  Adrenaline (again)
  References
  Cholinergic receptor subtypes; nicotinic and muscarinic
  Nicotinic acetylcholine receptors
  Muscarinic acetylcholine receptors
  Type IV nicotinic AChR induces skeletal muscle contraction
  Acetylcholine, acting on the M2-receptor, reduces force and slows down the heart rate
  Phosphodiesterases
  Acetylcholine, acting on the M3 receptor, causes airway constriction and mucus secretion
  Acetylcholine and the induction of nitric oxide, a potent vasodilator
  Neurotransmitters that function with both ionotropic and metabotropic signaling mechanisms
  References
  Ocular photoreceptor cells
  Photoreceptor mechanisms
  Electric activity of rod cells
  Sensitivity of photoreceptors and adaptation to changing light intensities
  Note on phototransduction in invertebrates
  Olfaction
  Chemosensors
  Olfactory epithelium
  Odorant receptor signaling
  Other signaling pathways involved in chemosensing
  Pheromone reviews
  GPCR superfamily
  References
  Free, bound, and trapped Ca2+
  Cytosolic Ca2+ is kept low
  Ca2+-binding proteins
  Ca2+ receptors
  Ca2+/calmodulin-mediated regulation of protein activity
  Tools to study the role of Ca2+ in cellular processes
  Mechanisms that elevate cytosol Ca2+ concentration
  Decoding Ca2+ oscillations
  Mobilizing Ca2+ through cyclic ADP ribose, NAADP, and sphingosine-l-phosphate
  Ca2+ in action
  Michael Abercrombie a pioneer in cell migration
  References
  Glucagon and glucocorticoids augment gluconeogenesis
  Signaling through the glucagon receptor
  Protein kinase A
  AKAP, anchoring and scaffolding
  Activation of PKA by CAMP
  PKA substrates involved in gluconeogenesis
  CREB, a nuclear target of PKA
  CREB is member of the basic leucine zipper (bZIP) family of proteins
  Transcription and transcription factors
  Ser133-phosphorylated CREB recruits coactivators CREBBP, PE300, and CRTC2
  CREB stimulates the gluconeogenic program
  Glucagon and cortisol (glucocorticoid) cooperate
  Insulin causes disassembly of the CREB-mediated PIC
  Diabetes and enhanced gluconeogenesis
  References
  Steroids accumulate in the nucleus
  Steroids regulate gene transcription
  superfamily of nuclear receptors
  Domain architecture and general structure of the DNA-protein complex
  Nuclear receptors in context: cross-talk with other transcription factors
  Non-genomic signaling modes of nuclear receptors
  Three precise descriptions of steroids in action in the context of pregnancy
  Endocrine disruption in a plastic world: the example of bisphenol A
  References
  protein kinase C family
  Structural composition of protein kinase C
  Priming and activation of conventional and novel protein kinase C
  Priming and activation of atypical protein kinase C
  Multiple sources of diacylglycerol and other lipids to regulate protein kinase C
  Differential localization of protein kinase C isoforms
  Different types of protein kinase C-binding proteins
  Holding back the PKC response
  Protein kinase C in the context of oncogenic transformation
  Atypical protein kinase C and the regulation of cell polarity
  Atypical protein kinase C in cell migration and axonal outgrowth
  References
  Spotting phosphotyrosine
  v-Src and other protein tyrosine kinases
  Focus on the ERBB receptor family, their ligands, and their dimer partners
  Cross-linking of receptors causes activation
  Oncogenenic mutations
  Protein domains that bind phosphotyrosines and the assembly of signaling complexes
  Branching of the signaling Pathway
  RAS-MAP kinase pathway
  Fine tuning the RAS-MAP-kinase pathway: scaffold proteins
  Why are the signaling pathways so complicated?
  Termination of the ERK1/2 response
  family of MAP-kinase-related proteins
  MAP kinases in other organisms
  Other branches of the EGFR signaling pathways
  References
  Naming names
  Immunoglobulin superfamily
  Claudins
  Occludins
  Integrins
  Cadherins
  Selectins
  Cartilage link proteins
  Integrins, cell survival, and cell proliferation
  Signaling from cadherin clusters
  References
  discovery of the WNT family of cytokines
  WNT signals through β-catenin
  Switching TCF from a repressor to an activator
  Adenomatous polyposis coli and the regulation of subcellular localization of β-catenin
  Take your partner: which way β-catenin?
  WTN signaling disables the AXIN-APC destruction complex
  Regulation of gene transcription by β-catenin
  More about the TCF family
  WNT target genes with a WNT-enhancer element
  Extracellular inhibitors of WNT and its receptors
  Contribution of different species to the elucidation of the WNT signal transduction pathway
  WNT signaling and stem cell self-renewal
  WNT and planar cell polarity
  Mutations of CTNNB1, AXIN, and APC in human cancers
  References
  Sensing the microbial universe
  Signaling through the TLR4 receptor
  IRF family of transcription factors
  Negative feedback control of the TLR4 pathway
  Some consequences of TLR4-induced gene transcription
  Essay: Ubiquitinylation and Sumoylation
  References
  Inflammatory mediators
  Tumor necrosis factor: potential antitumor agent or inflammatory cytokine?
  family of TNF proteins and receptors
  TNF and regulation of adhesion molecule expression in endothelial cells
  Chemokines and activation of integrins on leukocytes
  Cellular protrusions aid in probing permissive sites on the endothelial surface
  Migration within the tissue
  three-step process of leukocyte adhesion to endothelial cells
  References
  T-cell receptor signaling
  Down-regulation of the TCR response
  lipid raft hypothesis
  Signaling through the interferon receptors
  Oncogenes, malignancy, and signal transduction
  Essay: non-receptor PTKs and their regulation
  References
  Signaling through phosphoinositides
  Phosphatidyl inositol 3-kinase
  Studying the role of PI3-kinase with inhibitors
  Pathways of activation for PI3-kinase
  AKT and activation through PI-3,4,5-P3
  Insulin: the role of IRS, P13-kinase and AKT in the regulation of glycogen synthesis
  role of PI3-kinase in activation of protein synthesis
  RHEB and TSC
  Integration of growth factor and nutrient signaling
  Pβ-kinase, regulator of cell size, proliferation, and transformation
  Other processes mediated by the 3-phosphorylated inositol phospholipids
  References
  TGFβ receptors, type-I and type-II
  TGFP-mediated receptor activation
  Accessory and pseudo-receptors: TGFBR3, ENG, TDGF1, and BAMBI
  Downstream signaling: Drosophila, Caenorhabditis, and SMAD
  SMAD proteins have multiple roles in signal transduction
  Regulation of Transcription by SMAD Proteins
  Cooperation with other pathways and other transcription factors
  Holding the TGFβ pathway in check
  TGFβ: tumor suppressor and metastatic promoter?
  Noncanonical pathways
  References
  Protein tyrosine phosphatases
  Protein serine/threonine phosphatases
  References
  One gene, many alleles
  Membrane components of the Notch pathway
  Activation of Notchl
  Destruction of the Notchl-intracellular domain, Nicd
  Both receptor and ligand trafficking are essential for Notch signaling
  Notch in Drosophila development
  Notch in the maintenance of an intestinal stem compartment
  Cross-talk with other signal transduction pathways
  Contents note continued: Notch and disease
  References.