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    Understanding Toxicology : a biological approach / Steven D. Mercurio.

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    • Title:Understanding Toxicology : a biological approach / Steven D. Mercurio.
    •    
    • Author/Creator:Mercurio, Steven D., author.
    • Published/Created:Burlington, MA : Jones & Bartlett Learning, [2017]

    • Holdings

      Holdings Record Display

       
    • Library of Congress Subjects:Environmental toxicology.
    • Medical Subjects: Drug-Related Side Effects and Adverse Reactions.
      Toxicology.
      Biological Factors--toxicity.
      Hazardous Substances--toxicity.
      Environmental Exposure.
    • Description:xix, 952 pages : illustrations ; 26 cm
    • Notes:Includes bibliographical references and index.
    • ISBN:9780763771164 paperback
      0763771163 paperback
    • Contents:Machine generated contents note: 1. Biological Research in Toxicology
      Toxicology Research Area Specialties
      Selected Research Experiments to Consider During Your Study of Toxicology
      Biology as the Arbiter of Toxicology
      Questions
      References
      2. Development of the Field of Toxicology
      Development of the Science of Toxicology
      Questions
      References
      3. Toxicology Terms and How They Relate to Organisms
      Cell
      Tissues, Organs, and Complex Organisms
      Ecosystems
      Questions
      References
      4. Hazard, Exposure, and Risk Modeling
      Framework
      Cells
      Complex Organisms-Tissues and Organs: Therapeutic or Human Risk
      Ecosystems
      Questions
      References
      5. Absorption and Transport of Toxicants Through Membranes: Toxic Damage to Membranes
      Cellular Barriers
      Mechanisms of Cellular Transport
      Mechanisms of Membrane Damage
      Questions
      References
      6. Receptor-Mediated Toxicities on the Outside of Cells
      Receptors and Signal Transduction Mechanisms
      Targeting lon-Channel Receptors
      Targeting Transmembrane Enzyme Receptors and Downstream Enzymes
      Targeting G Protein-Linked Receptors and Downstream Signal Transduction
      Questions
      References
      7. Detoxication and Activation by Cells: Metabolism of the Original Toxicant
      Biotransformation
      Anaerobic Bacteria
      Hybrid Reactions of Facultative Anaerobes: Metabolism of Aromatic Compounds
      Aerobic Organisms' Phase 1 Metabolism
      Aerobic Organisms' Phase 2 Metabolism: Conjugation
      Questions
      References
      8. Damage to Cytosolic and Endoplasmic Reticulum Activities
      Reactive Chemical Species
      Cellular Damage and Adaptation Mechanisms
      Antidotes
      Questions
      References
      9. Damage to Mitochondria! and Chloroplast Activities
      Mitochondria
      Chloroplasts and Plant Mitochondria
      Questions
      References
      10. Damage to Nuclear Structures/DNA: Mutagenesis and Carcinogenesis
      Nuclear Membrane
      Mutagenesis
      Carcinogenesis
      Questions
      References
      11. Selective Genetic Sensitivity of Cells to Toxicants
      Selective Toxicity
      Absorption and Elimination Differences
      Metabolism/CYP Polymorphisms
      Receptor Interaction Alterations
      Questions
      References
      12. Nutritional Toxicity and Sensitivity
      Nutritional Toxicology
      Undernutrition
      Overnutrition/Pharmacologic or Toxic Concentrations of Nutrients
      Naturally Occurring Toxicants in Food
      Genetics and Nutrition/Nutritional Genomics
      Questions
      References
      13. Routes of Administration and Which Organs Are Most Likely Impacted Based on Route and Toxicokinetic Models
      Transcutaneous Absorption
      Ocular Absorption
      Oral Absorption
      Inhalation
      Parenteral Routes
      Questions
      References
      14. Forensic Toxicity Testing
      Most Likely Suspects
      Signs/Symptoms of Exposure
      Sampling Techniques
      Analysis Methodology
      Flow Chart of a Typical Postmortem Examination
      Therapeutic Drug (Medication) Monitoring in Living Human Patients
      Questions
      References
      15. Skin and Eye: Most Likely Exposure Routes and Toxicities Due to Contact Exposure and Dose Toxicities
      Forensic Analysis of Skin Damage
      Percutaneous Absorption
      Dermal Toxicity Tests
      Forensic Analysis of Eye Damage
      Eye Toxicity Tests
      Questions
      References
      16. Gastrointestinal System Toxicity and Oral Exposure (GI Tract, Pancreas, Liver)
      Forensic Analysis of GI Damage
      Forensic Analysis of Pancreatic Damage
      Forensic Analysis of Liver Damage
      GI Toxicity Tests
      Pancreas Toxicity Tests
      Liver Toxicity Tests
      Questions
      References
      17. Lung and Gill Exposures Representing Toxic Concentrations - Model for Environmental Toxicology
      Forensic Analysis of Lung Damage
      Forensic Analysis of Gill Damage
      Lung Toxicity Tests
      Gill Toxicity Tests
      Microcosm for Environmental Toxicology
      Questions
      References
      18. Cardiovascular System as Conduit for a Dose Becoming a Dosage: Exposure and Toxicities
      Forensic Analysis of Blood as a Diagnostic Tool
      Forensic Analysis of Vascular Toxicants
      Forensic Analysis of Cardiac Toxicants
      Questions
      References
      19. Bone Marrow and Immune Organ Toxicity via Lymphatic and Blood Transport
      Recognition of Foreign Antigens
      Hypersensitivity Reactions (Allergy and Autoimmunity)
      Autoimmunity Versus Immune Suppression
      Toxicity Tests
      Questions
      References
      20. Nervous System and Exposure to Lipophilic Toxicants or Transported Neurotoxic Agents
      Central Nervous System Toxicity
      Nerve Toxicity Tests
      Questions
      References
      21. Toxicity to Neuroendocrine Organs and Endocrine Disruption
      Primary Endocrine Organs
      Secondary Endocrine Organs
      Endocrine Organ Disruption Tests
      Questions
      References
      22. Toxicity to Reproductive Organs and Developmental Toxicity
      Mutagenic Damage
      Epigenetic Developmental Disruption
      Early Male Developmental Toxicity
      Early Female Developmental Toxicity
      Fertilization
      Embryo Toxicity/Fetal Toxicity
      Late Male Developmental Toxicity
      Late Female Developmental Toxicity
      Reproductive/Developmental Tests
      Questions
      References
      23. Excretion of Hydrophilic Toxicants and Metabolites and Kidney Toxicity
      Prerenal Azotemia
      Vascular Damage
      Glomerular Damage
      Proximal Convoluted Tubular (PCT) Injury
      Interstitium
      Loop of Henle
      Distal Convoluted Tubule
      Collecting Duct
      Acid-Base Balance and Electrolyte Balance
      Species Specificity
      Kidney Toxicity Tests
      Questions
      References
      24. Dispersion Modeling in Air, Water, and Soil: Likely Route of Exposure and Most Sensitive Organism Based on Dispersion and Concentration
      Ecotoxicology and Environmental Toxicology
      Dispersion
      Route of Exposure
      Questions
      References
      25. Agricultural Chemicals (Pesticides and Fertilizers): Exposure and Impacts
      Fertilizers/Nutrients
      Pesticides
      Questions
      References
      26. Industrial Chemicals That Biodegrade: Organic Chemical Exposures and Impacts
      Solvents
      PAHs (Arenes-Multiple Rings)
      Polychlorinated Biphenyls (PCBs)
      Dibenzodioxins and Dibenzofurans
      Questions
      References
      27. Industrial Chemicals That Change Lipophilicity But Do Not Biodegrade: Metal Impacts
      Toxic Metals
      Essential Metals
      Biological Interest: Nickel
      Medical
      Questions
      References
      28. Industrial Chemicals That Cause Atmospheric Changes and Direct Versus Indirect Toxicity: Gases, Vapors, Aerosols, and Radiation
      Gases and Vapors-Direct Effects
      Aerosols-Direct Effects
      Gases and Vapors-Indirect Effects
      Particles- Indirect Effects
      Radiation
      Questions
      References
      29. Toxicity of Pharmaceuticals and Personal Care Products (PPCPs) into Water
      Environmental Effects of PPCPs
      Possible Human Effects of PPCPs
      Treatment of Effluents to Prevent Exposure to PPCPs
      Questions
      References
      30. Venoms and Injection Toxicity Versus Poisonous Animals or Cells and Ingestion or Contact Toxicity
      Chordata: Amniota: Reptilia: Squamata Venoms
      Eumetazoa: Bilateria: Ecdysozoa: Arthropod Venoms
      Chordata: Craniata Venoms
      Lophotrochozoa: Mollusca Venoms
      Eumetazoa: Cnidaria Venoms
      Echinodermata: Holothuroidea Venom
      Chordata: Mammalia: Eutheria: Soricomorpha: Soricidae Venoms
      Venom Economy
      Chordata: Tetrapoda: Amphibia Poisons
      Fish Poisons
      Chordata: Avialae: Ayes Poisons
      Discussion of Poisons' Evolution and Proper Attribution/ Biological Classification
      Eukarya: Chromalveolata: Alveolata: Dinoflagellata Poisons
      Eukaryota: Chromalveolata: Heterokontophyta: Bacillariophyceae Poisons
      Eukaryota: Opisthokonta: Fungi Poisons
      Bacteria Poisons
      Questions
      References
      31. Poisonous Plants or Plant Cells and Ingestion or Contact Toxicity
      Seed Poisons
      Root Poisons
      Fruit Poisons
      Plant Leaves and Flowers
      Questions
      References.
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