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    Introduction to genetic analysis / Anthony J.F. Griffiths, University of British Columbia; Susan R. Wessler, University of California, Riverside; Sean B. Carroll, Howard Hughes Medical Institute, University of Wisconsin--Madison; John Doebley, University of Wisconsin--Madison.

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    • Title:Introduction to genetic analysis / Anthony J.F. Griffiths, University of British Columbia; Susan R. Wessler, University of California, Riverside; Sean B. Carroll, Howard Hughes Medical Institute, University of Wisconsin--Madison; John Doebley, University of Wisconsin--Madison.
    •    
    • Variant Title:Genetic analysis
    • Author/Creator:Griffiths, Anthony J. F., author.
    • Other Contributors/Collections:Wessler, Susan R., author.
      Carroll, Sean B., author.
      Doebley, John F., author.
    • Published/Created:New York, NY : W.H. Freeman and Company, [2015]
      ©2015

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    • Library of Congress Subjects:Genetics.
      Molecular genetics.
    • Medical Subjects: Genetic Phenomena.
      Genetic Techniques.
    • Edition:Eleventh edition.
    • Description:xxiii, 868 pages : illustrations (chiefly color), color map ; 29 cm
    • Summary:"With each edition, An Introduction to Genetic Analysis (IGA) evolves discovery by discovery with the world of genetic research, taking students from the foundations of Mendelian genetics to the latest findings and applications by focusing on the landmark experiments that define the field. With its author team of prominent scientists who are also highly accomplished educators, IGA again combines exceptional currency, expansive updating of its acclaimed problem sets, and a variety of new ways to learn genetics. Foremost is this edition's dedicated version of W.H. Freeman's breakthrough online course space, LaunchPad, which offers a number of new and enhanced interactive tools that advance IGA's core mission: to show students how to analyze experimental data and draw their own conclusions based on scientific thinking while teaching students how to think like geneticists, "--Publisher's website.
    • Notes:Preceded by Introduction to genetic analysis / Anthony J.F. Griffiths [and others]. 10th ed. c2012.
      Includes bibliographical references and index.
    • ISBN:9781464109485 hardcover
      1464109486 hardcover
      9781464188046 loose-leaf
      1464188041 loose-leaf
    • Contents:Preface
      1. The Genetics Revolution
      1.1 The birth of genetics
      1.2 After cracking the code
      1.3 Genetics today
      Part I: Transmission Genetics. 2. Single-Gene Inheritance
      2.1 Single-gene inheritance patterns
      2.2 The chromosomal basis of single-gene inheritance patterns
      2.3 The molecular basis of mendelian inheritance patterns
      2.4 Some genes discovered by observing segregation ratios
      2.5 Sex-linked single-gene inheritance patterns
      2.6 Human pedigree analysis
      3. Independent Assortment of Genes
      3.1 Mendel's Law of Independent Assortment
      3.2 Working with independent assortment
      3.3 The chromosomal basis of independent assortment
      3.4 Polygenic inheritance
      3.5 Organelle genes: inheritance independent of the nucleus
      4. Mapping Eukaryote Chromosomes by Recombination
      4.1 Diagnostics of linkage
      4.2 Mapping by recombinant frequency
      4.3 Mapping with molecular markers
      4.4 Centromere mapping with linear tetrads
      4.5 Using the Chi-Square test to infer linkage
      4.6 Accounting for unseen multiple crossovers
      4.7 Using recombination-based maps in conjunction with physical maps
      4.8 The molecular mechanism of crossing over
      5. The Genetics of Bacteria and Their Viruses
      5.1 Working with microorganisms
      5.2 Bacterial conjugation
      5.3 Bacterial transformation
      5.4 Bacteriophage genetics
      5.5 Transduction
      5.6 Physical maps and linkage maps compared
      6. Gene Interaction
      6.1 Interactions between the alleles of a single gene: variations of dominance
      6.2 Interaction of genes in pathways
      6.3 Inferring gene interactions
      6.4 Penetrance and expressivity. Part II: From DNA to Phenotype. 7. DNA: Structure and Replication
      7.1 DNA: the genetic material
      7.2 DNA structure
      7.3 Semiconservative replication
      7.4 Overview of DNA replication
      7.5 The replisome: a remarkable replication machine
      7.6 Replication in eukaryotic organisms
      7.7 Telomeres and telomerase: replication termination
      8. RNA: Transcription and Processing
      8.1 RNA
      8.2 Transcription
      8.3 Transcription in eukaryotes
      8.4 Intron removal and exon splicing
      8.5 Small functional RNAs that regulate and protect the eukaryotic genome
      9. Proteins and Their Synthesis
      9.1 Protein structure
      9.2 The genetic code
      9.3 tRNA: the adapter
      9.4 Ribosomes
      9.5 The proteome
      10. Gene Isolation and Manipulation
      10.1 Overview: isolating and amplifying specific DNA fragments
      10.2 Generating recombinant DNA molecules
      10.3 Using molecular probes to find and analyze a specific clone of interest
      10.4 Determining the base sequence of a DNA segment
      10.5 Aligning genetic and physical maps to isolate specific genes
      10.6 Genetic engineering
      11. Regulation of Gene Expression in Bacteria and Their Viruses
      11.1 Gene regulation
      11.2 Discovery of the lac system: negative control
      11.3 Catabolite repression of the lac operon: positive control
      11.4 Dual positive and negative control: the arabinose operon
      11.5 Metabolic pathways and additional levels of regulation: attenuation
      11.6 Bacteriophage life cycles: more regulators, complex operons
      11.7 Alternative sigma factors regulate large sets of genes
      12. Regulation of Gene Expression in Eukaryotes
      12.1 Transcriptional regulation in eukaryotes: an overview
      12.2 Lessons from yeast: the GAL system
      12.3 Dynamic chromatin
      12.4 Activation of genes in a chromatin environment
      12.5 Long-term inactivation of genes in a chromatin environment
      12.6 Gender-specific silencing of genes and whole chromosomes
      12.7 Post-transcriptional gene repression by miRNAs
      13. The Genetic Control of Development
      13.1 The genetic approach to development
      13.2 The genetic toolkit for Drosophila development
      13.3 Defining the entire toolkit
      13.4 Spatial regulation of gene expression in development
      13.5 Post-transcriptional regulation of gene expression in development
      13.6 From files to fingers, feathers and floor plates: the many roles of individual toolkit genes
      13.7 Development and disease
      14. Genomes and Genomics
      14.1 The genomics revolution
      14.2 Obtaining the sequence of a genome
      14.3 Bioinformatics: meaning from genomic sequence
      14.4 The structure of the human genome
      14.5 The comparative genomics of humans with other species
      14.6 Comparative genomics and human medicine
      14.7 Functional genomics and reverse genetics. Part III: Mutation, variation, and evolution. 15. The Dynamic Genome: Transposable Elements
      15.1 Discovery of transposable elements in Maize
      15.2 Transposable elements in prokaryotes
      15.3 Transposable elements in eukaryotes
      15.4 The dynamic genome: more transposable elements than ever imagined
      15.5 Regulation of transposable element movement by the host
      16. Mutation, Repair, and Recombination
      16.1 The phenotypic consequences of DNA mutations
      16.2 The molecular basis of spontaneous mutations
      16.3 The molecular basis of induced mutations
      16.4 Biological repair mechanisms
      16.5 Cancer: an important phenotypic consequence of mutation
      17. Large-Scale Chromosomal Changes
      17.1 Changes in chromosome number
      17.2 Changes in chromosome structure
      17.3 Overall incidence of human chromosome mutations
      18. Population Genetics
      18.1 Detecting genetic variation
      18.2 The gene-pool concept and the Hardy-Weinberg Law
      18.3 Mating systems
      18.4 Genetic variation and its measurement
      18.5 The modulation of genetic variation
      18.6 Biological and social applications
      19. The Inheritance of Complex Traits
      19.1 Measuring quantitative variation
      19.2 A simple genetic model for quantitative traits
      19.3 Broad-sense heritability: nature versus nurture
      19.4 Narrow-sense heritability: predicting phenotypes
      19.5 Mapping QTL in populations with known pedigrees
      19.6 Association mapping in random-mating populations
      20. Evolution of Genes and Traits
      20.1 Evolution by natural selection
      20.2 Natural selection in action: an exemplary case
      20.3 Molecular evolution: the neutral theory
      20.4 Cumulative selection and multistep paths to functional change
      20.5 Morphological evolution
      20.6 The origin of new genes and protein functions
      A brief guide to model organisms
      Appendix A: genetic nomenclature
      Appendix B: bioinformatics resources for genetics and genomics
      Glossary
      Answers to selected problems
      Index.
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