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• Title:Genetic association studies : background, conduct, analysis, interpretation / Mehmet Tevfik Dorak.
  
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• Author/Creator:Dorak, M. Tevfik, author.
  
• Published/Created:New York, NY : Garland Science, Taylor & Francis Group, LLC, [2017]
  ©2017
  

• Holdings

  Holdings Record Display

  • Location:WOODWARD LIBRARY stacksWhere is this?
    
  • Call Number: QH437 .D67 2017
    
  • Number of Items:1
    
  • Status:Available
    

   
• Library of Congress Subjects:Genomics.
  Population genetics.
  Medical genetics.
  Human genetics--Variation.
  Human genetics--Popular works.
  
• Medical Subjects: Molecular Epidemiology--methods.
  
• Description:230 pages : illustrations ; 25 cm
  
• Summary:Genetic Association Studies is designed for students of public health, epidemiology, and the health sciences, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in genetic disease is also highlighted. Genetic Association Studies will enable readers to understand and critique genetic association studies and set them on the way to designing, executing, analyzing, interpreting, and reporting their own.
  
• Notes:Includes bibliographical references.
  
• ISBN:9780815344636 (alk. paper)
  0815344635 (alk. paper)
  
• Contents:Machine generated contents note: 1. Primer on Molecular Genetics
  1.1. Genetic Variation
  1.2. Human Genome
  1.3. Consequences of Genetic Variation
  1.4. Genetic Nomenclature
  2. Primer on Medical Genetics
  2.1. Location of Disease-causing Mutations
  2.2. Single-Gene, Oligogenic, and Multigenic Disorders
  2.3. Copy Number of Mutant Genes
  2.4. Inherited Mutations
  3. Primer on Population Genetics
  3.1. Hardy
  Weinberg Equilibrium
  3.2. Linkage Disequilibrium
  3.3. Population Substructure
  3.4. Signatures of Natural Selection
  4. Epidemiologic Principles and Genetic Association Studies
  4.1. Types of Epidemiologic Association Studies
  4.2. Chance, Bias, Confounding, and Effect Modification
  4.3. Causality and Statistical Association
  5. Environmental Epidemiology In the Context of Genetic Epidemiology
  5.1. Studying Environmental Effects
  5.2. Examining and Estimating Environmental Effects
  5.3. Environment and Gene Activity
  5.4. Gene and Environment Interactions, Personalized Prevention, and Treatment
  6. Elementary Statistical Concepts
  6.1. Statistical Power and Statistical Significance
  6.2. Study Design and Errors
  6.3. Data Analysis
  7. Genotyping Methods and Errors
  7.1. Genotyping Principles
  7.2. Genotyping and PCR
  7.3. Choice of Genotyping Method
  7.4. Sources of DNA for Genotyping
  7.5. Genotyping Errors
  7.6. Imputing Genotypes
  8. Candidate Gene Studies and Genome-Wide Association Studies
  8.1. Candidate Genes
  8.2. Candidate Variants
  8.3. Candidate Gene Studies in the GWAS age
  8.4. Advantages and Disadvantages of a GWAS
  9. Statistical Analysis of Genetic Association Study Results
  9.1. Standard Genetic Association Analysis
  9.2. GWAS Analysis
  10. Bioinformatics for the Interpretation of Genetic Association Study Results
  10.1. Bioinformatics for Testing SNP Associations
  10.2. Functional Annotation of SNPs
  10.3. Analyzing Functionally Altered Genes
  11. Genetic Risk Profiling and Medical Applications of Genetic Associations
  11.1. Genetic Risk Profiling and Genetic Markers
  11.2. Assessing Clinical Utility
  11.3. Disease Biology and Pharmacogenomics.