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• Title:Cell and molecular biology : concepts and experiments / Gerald Karp.
  
•    
• Author/Creator:Karp, Gerald.
  
• Other Contributors/Collections:Patton, James G.
  
• Published/Created:Hoboken, NJ : John Wiley, ©2013.
  

• Holdings

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  • Location:WOODWARD LIBRARY stacksWhere is this?
    
  • Call Number: QU300 .K18c 2013
    
  • Number of Items:1
    
  • Status:Available
    

   
• Library of Congress Subjects:Cytology.
  Molecular biology.
  
• Medical Subjects: Cells.
  Molecular Biology.
  
• Edition:7th ed.
  
• Description:xvi, 783, [63] pages : illustrations (chiefly col) ; 29 cm
  
• Summary:This Seventh Edition connects experimental material to key concepts of Cell Biology. The text offers streamlined information that reinforces a connection of key concepts to experimentation. Though the use paired art, and new science illustrations, readers benefit from a visual representation of experimental connections. Animated clips are tied to key illustrations with practice questions to provide a variety of ways to experience a key concept. This new edition offers an appropriate balance of concepts and experimentation. Experimental detail is offered when it helps to reinforce the concept being explained.
  
• Notes:"Chapter 12 was revised in collaboration with James G. Patton."
  Includes bibliographical references and index.
  
• ISBN:9781118206737
  1118206738
  9781118301791
  111830179X
  
• Contents:Machine generated contents note: 1.1. Discovery of Cells
  1.2. Basic Properties of Cells
  Cells Are Highly Complex and Organized
  Cells Possess a Generic Program and the Means to Use It
  Cells Are Capable of Producing More of Themselves
  Cells Acquire and Utilize Energy
  Cells Carry Out a Variety of Chemical Reactions
  Cells Engage in Mechanical Activities
  Cells Are Able to Respond to Stimuli
  Cells Are Capable of Self-Regulation
  Cells Evolve
  1.3. Two Fundamentally Different Classes of Cells
  Characteristics That Distinguish Prokaryotic and Eukaryotic Cells
  Types of Prokaryotic Cells
  Types of Eukaryotic Cells: Cell Specialization
  Sizes of Cells and Their Components
  Synthetic Biology
  Human Perspective: The Prospect of Cell Replacement Therapy
  1.4. Viruses
  Viroids
  Experimental Pathways: The Origin of Eukaryotic Cells
  2.1. Covalent Bonds
  Polar and Nonpolar Molecules
  Ionizaton
  2.2. Noncovalent Bonds
  Human Perspective: Free Radicals as a Cause of Aging
  Ionic Bonds: Attractions between Charged Atoms
  Hydrogen Bonds
  Hydrophobic Interactions and van der Waals Forces
  Life-Supporting Properties of Water
  2.3. Acids, Bases, and Buffers
  2.4. Nature of Biological Molecules
  Functional Groups
  Classification of Biological Molecules by Function
  2.5. Four Types of Biological Molecules
  Carbohydrates
  Lipids
  Proteins
  Human Perspective: Protein Misfolding Can Have Deadly Consequences
  Nucleic Acids
  2.6. Formation of Complex Macromolecular Structures
  Assembly of Tobacco Mosaic Virus Particles and Ribosomal Subunits
  Experimental Pathways: Chaperones: Helping Proteins Reach Their Proper Folded State
  3.1. Bioenergetics
  Laws of Thermodynamics and the Concept of Entropy
  Free Energy
  3.2. Enzymes as Biological Catalysts
  Properties of Enzymes
  Overcoming the Activation Energy Barrier
  Active Site
  Mechanisms of Enzyme Catalysis
  Enzyme Kinetics
  Human Perspective: The Growing Problem of Antibiotic Resistance
  3.3. Metabolism
  Overview of Metabolism
  Oxidation and Reduction: A Matter of Electrons
  Capture and Utilization of Energy
  Metabolic Regulation
  4.1. Overview of Membrane Functions
  4.2. Brief History of Studies on Plasma Membrane Structure
  4.3. Chemical Composition of Membranes
  Membrane Lipids
  Asymmetry of Membrane Lipids
  Membrane Carbohydrates
  4.4. Structure and Functions of Membrane Proteins
  Integral Membrane Proteins
  Studying the Structure and Properties of Integral Membrane Proteins
  Peripheral Membrane Proteins
  Lipid-Anchored Membrane Proteins
  4.5. Membrane Lipids and Membrane Fluidity
  Importance of Membrane Fluidity
  Maintaining Membrane Fluidity
  Lipid Rafts
  4.6. Dynamic Nature of the Plasma Membrane
  Diffusion of Membrane Proteins after Cell Fusion
  Restrictions on Protein and Lipid Mobility
  Red Blood Cell: An Example of Plasma Membrane Structure
  4.7. Movement of Substances Across Cell Membranes
  Energetics of Solute Movement
  Diffusion of Substances through Membranes
  Facilitated Diffusion
  Active Transport
  Human Perspective: Defects in Ion Channels and Transporters as a Cause of Inherited Disease
  4.8. Membrane Potentials and Nerve Impulses
  Resting Potential
  Action Potential
  Propagation of Action Potentials as an Impulse
  Neurotransmission: Jumping the Synaptic Cleft
  Experimental Pathways: The Acetylcholine Receptor
  5.1. Mitochondria! Structure and Function
  Mitochondrial Membranes
  Mitochondrial Matrix
  5.2. Oxidative Metabolism in the Mitochondrion
  Tricarboxylic Acid (TCA) Cycle
  Importance of Reduced Coenzymes in the Formation of ATP
  Human Perspective: The Role of Anaerobic and Aerobic Metabolism in Exercise
  5.3. Role of Mitochondria in the Formation of ATP
  Oxidation[-]Reduction Potentials
  Electron Transport
  Types of Electron Carriers
  5.4. Translocation of Protons and the Establishment of a Proton-Motive Force
  5.5. Machinery for ATP Formation
  Structure of ATP Synthase
  Basis of ATP Formation According to the Binding Change Mechanism
  Other Roles the Proton-Motive Puree in Addition to ATP Synthesis
  5.6. Peroxisomes
  Human Perspective: Diseases that Result from Abnormal Mitochondrial or Peroxisomal Function
  6.1. Chloroplast Structure and Function
  6.2. Overview of Photosynthetic Metabolism
  6.3. Absorption of Light
  Photosynthetic Pigments
  6.4. Photosynthetic Units and Reaction Centers
  Oxygen Formation: Coordinating the Action of Two Different Photosynthetic Systems
  Killing Weeds by Inhibiting Electron Transport
  6.5. Photophosphorylation
  Noncyclic Versus Cyclic Photophosphorylation
  6.6. Carbon Dioxide Fixation and the Synthesis of Carbohydrate
  Carbohydrate Synthesis in C3 Plants
  Carbohydrate Synthesis in C4 Plants
  Carbohydrate Synthesis in CAM Plants
  7.1. Extracellular Space
  Extracellular Matrix
  7.2. Interactions of Cells with Extracellular Materials
  Integrins
  Focal Adhesions and Hemidesmosomes: Anchoring Cells to Their Substratum
  7.3. Interactions of Cells with Other Cells
  Selectins
  Immunoglobulin Superfamily
  Cadherins
  Human Perspective: The Role of Cell Adhesion in Inflammation and Metastasis
  Adherens Junctions and Desmosomes: Anchoring Cells to Other Cells
  Role of Cell-Adhesion Receptors in Transmembrane Signaling
  7.4. Tight Junctions: Sealing The Extracellular Space
  7.5. Gap Junctions and Plasmodesmata: Mediating Intercellular Communication
  Plasmodesmata
  7.6. Cell Walls
  8.1. Overview of the Endomembrane System
  8.2. Few Approaches to the Study of Endomembranes
  Insights Gained from Autoradiography
  Insights Gained from the Use of the Green Fluorescent Protein
  Insights Gained from the Biochemical Analysis of Subcellular Fractions
  Insights Gained from the Use of Cell-Free Systems
  Insights Gained from the Study of Mutant Phenotypes
  8.3. Endoplasmic Reticulum
  Smooth Endoplasmic Reticulum
  Functions of the Rough Endoplasmic Reticulum
  From the ER to the Golgi Complex: The First Step in Vesicular Transport
  8.4. Golgi Complex
  Glycosylation in the Golgi Complex
  Movement of Materials through the Golgi Complex
  8.5. Types of Vesicle Transport and Their Functions
  COPII-Coated Vesicles: Transporting Cargo from the ER to the Golgi Complex
  COPI-Coated Vesicles: Transporting Escaped Proteins Back to the ER
  Beyond the Golgi Complex: Sorting Proteins at the TGN
  Targeting Vesicles to a Particular Compartment
  8.6. Lysosomes
  Autophagy
  Human Perspective: Disorders Resulting from Defects in Lysosomal Function
  8.7. Plant Cell Vacuoles
  8.8. Endocytic Pathway: Moving Membrane and Materials into the Cell Interior
  Endocytosis
  Phagocytosis
  8.9. Posttranslational Uptake of Proteins by Peroxisomes, Mitochondria, and Chloroplasts
  Uptake of Proteins into Peroxisomes
  Uptake of Proteins into Mitochondria
  Uptake of Proteins into Chloroplasts
  Experimental Pathways: Receptor-Mediated Endocytosis
  9.1. Overview of the Major Functions of the Cytoskeleton
  9.2. Study of the Cytoskeleton
  Use of Live-Cell Fluorescence Imaging
  Use of In Vitro and In Vivo Single-Molecule Assays
  Use of Fluorescence Imaging Techniques to Monitor the Dynamics of the Cytoskeleton
  9.3. Microtubules
  Structure and Composition
  Microtubule-Associated Proteins
  Microtubules as Structural Supports and Organizers
  Microtubules as Agents of Intracellular Motility
  Motor Proteins that Traverse the Microtubular Cytoskeleton
  Microtubule-Organizing Centers (MTOCs)
  Dynamic Properties of Microtubules
  Cilia and Flagella: Structure and Function
  Human Perspective: The Role of Cilia in Development and Disease
  9.4. Intermediate Filaments
  Intermediate Filament Assembly and Disassembly
  Types and Functions of Intermediate Filaments
  9.5. Microfilaments
  Microfilament Assembly and Disassembly
  Myosin: The Molecular Motor of Actin Filaments
  9.6. Muscle Contractility
  Sliding Filament Model of Muscle Contraction
  9.7. Nonmuscle Motility
  Actin-Binding Proteins
  Examples of Nonmuscle Motility and Contractility
  10.1. Concept of a Gene as a Unit of Inheritance
  10.2. Chromosomes: The Physical Carriers of the Genes
  Discovery of Chromosomes
  Chromosomes as the Carriers of Genetic Information
  Genetic Analysis in Drosophila
  Crossing Over and Recombination
  Mutagenesis and Giant Chromosomes
  10.3. Chemical Nature of the Gene
  Structure of DNA
  Watson-Crick Proposal
  DNA Supercoiling
  10.4. Structure of the Genome
  Complexity of the Genome
  Human Perspective: Diseases that Result from Expansion of Trinucleotide Repeats
  10.5. Stability of the Genome
  Whole-Genome Duplication (Polyploidization)
  Duplication and Modification of DNA Sequences
  "Jumping Genes" and the Dynamic Nature of the Genome
  10.6. Sequencing Genomes: The Footprints of Biological Evolution
  Comparative Genomics: "If It's Conserved, It Must Be Important"
  Genetic Basis of "Being Human"
  Genetic Variation Within the Human Species Population
  Human Perspective: Application of Genomic Analyses to Medicine
  Experimental Pathways: The Chemical Nature of the Gene
  11.1. Relationship between Genes, Proteins, and RNAs
  Overview of the Flow of Information through the Cell
  Contents note continued: 11.2. Overview of Transcription in Both Prokaryotic and Eukaryotic Cells
  Transcription in Bacteria
  Transcription and RNA Processing in Eukaryotic Cells
  11.3. Synthesis and Processing of Eukaryotic Ribosomal and Transfer RNAs
  Synthesizing the rRNA Precursor
  Processing the rRNA Precursor
  Synthesis and Processing of the 5S rRNA
  Transfer RNAs
  11.4. Synthesis and Processing of Eukaryotic Messenger RNAs
  Machinery for mRNA Transcription
  Split Genes: An Unexpected Finding
  Processing of Eukaryotic Messenger RNAs
  Evolutionary Implications of Split Genes and RNA Splicing
  Creating New Ribozymes in the Laboratory
  11.5. Small Regulatory RNAs and RNA Silencing Pathways
  Human Perspective: Clinical Applications of RNA Interference
  MicroRNAs: Small RNAs that Regulate Gene Expression
  piRNAs: A Class of Small RNAs that Function in Germ Cells
  Other Noncoding RNAs
  11.6. Encoding Genetic Information
  Properties of the Genetic Code
  11.7. Decoding the Codons: The Role of Transfer RNAs
  Structure of tRNAs
  11.8. Translating Genetic Information
  Initiation
  Elongation
  Termination
  mRNA Surveillance and Quality Control
  Polyribosomes
  Experimental Pathways: The Role of RNA as a Catalyst
  12.1. Control of Gene Expression in Bacteria
  Organization of Bacterial Genomes
  Bacterial Operon
  Riboswitches
  12.2. Control of Gene Expression in Eukaryotes: Structure and Function of the Cell Nucleus
  Nuclear Envelope
  Chromosomes and Chromatin
  Human Perspective: Chromosomal Aberrations and Human Disorders
  Epigenetics: There's More to Inheritance than DNA
  Nucleus as an Organized Organelle
  12.3. Overview of Gene Regulation in Eukaryotes
  12.4. Transcriptional Control
  Role of Transcription Factors in Regulating Gene Expression
  Structure of Transcription Factors
  DNA Sites Involved in Regulating Transcription
  Transcriptional Activation: The Role of Enhancers, Promoters, and Coactivators
  Transcriptional Repression
  12.5. RNA Processing Control
  12.6. Translational Control
  Initiation of Translation
  Cytoplasmic Localization of mRNAs
  Control of mRNA Stability
  Role of MicroRNAs in Translational Control
  12.7. Posttranslational Control: Determining Protein Stability
  13.1. DNA Replication
  Semiconservative Replication
  Replication in Bacterial Cells
  Structure and Functions of DNA Polymerases
  Replication in Eukaryotic Cells
  13.2. DNA Repair
  Nucleotide Excision Repair
  Base Excision Repair
  Mismatch Repair
  Double-Strand Breakage Repair
  13.3. Between Replication and Repair
  Human Perspective: The Consequences of DNA Repair Deficiencies
  14.1. Cell Cycle
  Cell Cycles in Vivo
  Control of the Cell Cycle
  14.2. M Phase: Mitosis and Cytokinesis
  Prophase
  Prometaphase
  Metaphase
  Anaphase
  Telophase
  Motor Proteins Required for Mitotic Movements
  Cytokinesis
  14.3. Meiosis
  Stages of Meiosis
  Human Perspective: Meiotic Nondisjunction and Its Consequences
  Genetic Recombination During Meiosis
  Experimental Pathways: The Discovery and Characterization of MPF
  15.1. Basic Elements of Cell Signaling Systems
  15.2. Survey of Extracellular Messengers and Their Receptors
  15.3. G Protein-Coupled Receptors and Their Second Messengers
  Signal Transduction by G Protein-Coupled Receptors
  Human Perspective: Disorders Associated with G Protein-Coupled Receptors
  Second Messengers
  Specificity of G Protein-Coupled Responses
  Regulation of Blood Glucose Levels
  Role of GPCRs in Sensory Perception
  15.4. Protein-Tyrosine Phosphorylation as a Mechanism for Signal Transduction
  Ras-MAP Kinase Pathway
  Signaling by the Insulin Receptor
  Human Perspective: Signaling Pathways and Human Longevity
  Signaling Pathways in Plants
  15.5. Role of Calcium as an Intracellular Messenger
  Regulating Calcium Concentrations in Plant Cells
  15.6. Convergence, Divergence, and Cross-Talk Among Different Signaling Pathways
  Examples of Convergence, Divergence, and Cross-Talk Among Signaling Pathways
  15.7. Role of NO as an Intercellular Messenger
  15.8. Apoptosis (Programmed Cell Death)
  Extrinsic Pathway of Apoptosis
  Intrinsic Pathway of Apoptosis
  16.1. Basic Properties of a Cancer Cell
  16.2. Causes of Cancer
  16.3. Genetics of Cancer
  Tumor-Suppressor Genes and Oncogenes: Brakes and Accelerators
  Cancer Genome
  Gene-Expression Analysis
  16.4. New Strategies for Combating Cancer
  Immunotherapy
  Inhibiting the Activity of Cancer-Promoting Proteins
  Inhibiting the Formation of New Blood Vessels (Angiogenesis)
  Experimental Pathways: The Discovery of Oncogenes
  17.1. Overview of the Immune Response
  Innate Immune Responses
  Adaptive Immune Responses
  17.2. Clonal Selection Theory as It Applies to B Cells
  Vaccination
  17.3. T Lymphocytes: Activation and Mechanism of Action
  17.4. Selected Topics on the Cellular and Molecular Basis of Immunity
  Modular Structure of Antibodies
  DNA Rearrangements that Produce Genes Encoding B- and T-Cell Antigen Receptors
  Membrane-Bound Antigen Receptor Complexes
  Major Histocompatibility Complex
  Distinguishing Self from Nonself
  Lymphocytes Are Activated by Cell-Surface Signals
  Signal Transduction Pathways in Lymphocyte Activation
  Human Perspective: Autoimmune Diseases
  Experimental Pathways: The Role of the Major Histocompatibility Complex in Antigen Presentation
  18.1. Light Microscope
  Resolution
  Visibility
  Preparation of Specimens for Bright-Field Light Microscopy
  Phase-Contrast Microscopy
  Fluorescence Microscopy (and Related Fluorescence-Based Techniques)
  Video Microscopy and Image Processing
  Laser Scanning Confocal Microscopy
  Super-Resolution Fluorescence Microscopy
  18.2. Transmission Electron Microscopy
  Specimen Preparation for Electron Microscopy
  18.3. Scanning Electron and Atomic Force Microscopy
  Atomic Force Microscopy
  18.4. Use of Radioisotopes
  18.5. Cell Culture
  18.6. Fractionation of a Cell's Contents by Differential Centrifugation
  18.7. Isolation, Purification, and Fractionation of Proteins
  Selective Precipitation
  Liquid Column Chromatography
  Polyacrylamide Gel Electrophoresis
  Protein Measurement and Analysis
  18.8. Determining the Structure of Proteins and Multisubunit Complexes
  18.9. Fractionation of Nucleic Acids
  Separation of DNAs by Gel Electrophoresis
  Separation of Nucleic Acids by Ultracentrifugation
  18.10. Nucleic Acid Hybridization
  18.11. Chemical Synthesis of DNA
  18.12. Recombinant DNA Technology
  Restriction Endonucleases
  Formation of Recombinant DNAs
  DNA Cloning
  18.13. Enzymatic Amplification of DNA by PCR
  Applications of PCR
  18.14. DNA Sequencing
  18.15. DNA Libraries
  Genomic Libraries
  cDNA Libraries
  18.16. DNA Transfer into Eukaryotic Cells and Mammalian Embryos
  18.17. Determining Eukaryotic Gene Function by Gene Elimination or Silencing
  In Vitro Mutagenesis
  Knockout Mice
  RNA Interference
  18.18. Use of Antibodies.