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    Holland-Frei cancer medicine / editors, Robert C. Bast, Jr, MD, Vice President for Translational Research, MD Anderson Cancer Center, Houston, Texas, Carlo M. Croce, MD, Distinguished University Professor, The John W. Wolfe in Human Cancer Genetics, Professor and Chair, Department of Molecular Virology, Immunology and Medical Genetics, The Wexner Medical Center, The Ohio State University, Columbus, Ohio, William Hait, PhD, Global Head, Research and Development, Janssen Pharmaceutical Companies of Johnson and Johnson, Raritan, New Jersey, Waun Ki Hong, MD, DMSc (Hon), Professor of Thoracic/Head and Neck Medical Oncology, American Cancer Society Professor, Samsung Distinguished University Chair in Cancer Medicine Emeritus, The University of Texas MD Anderson Cancer Center, Houston, Texas, Donald W. Kufe, MD, Distinguished Physician Dana-Farber Cancer Institute, Professor of Medicine, Harvard Medical School, Leader, Translational Pharmacology and Early Therapeutic Trials Program, Dana-Farbor/Harvard Cancer Center, Boston, Massachusetts, Martine Piccart-Gebhart, MD, PhD, Professor of Oncology, UniversiteĢ Libre de Bruxelles (ULB), Head of the MEdicine Department, Jules Bordet Institute, Brussels, Belgium, Raphael E. Pollock, MD, PhD, FACS, Professor and Director, Division of Surgical Oncology, Surgeon in Chief, James Comprehensive Cancer Center, Surgeon in Chief, The Ohio State University Health System, The Ohio State University Wexner Medical Center, Columbus, Ohio, Ralph R. Weichselbaum, MD, Professor and Director, National Center for Liver Cancer, China; Eastern Hepatobiliary Surgery Hospital, Shanghai, China, Hongyang Wang, MD, Professor and Director, National Center for Liver Cancer, China; Eastern Hepatobiliary Surgery Hospital, Shanghai, China, James F. Holland, MD, ScD (hc), Distinguished Professor of Neoplastic Disease, Director of Derald H. Ruttenberg Cancer Centerm Ichn School of Medicine at Mount Sinai, New York, New York ; associate editor Fadlo R. Khuri, MD, Executive Associate Dean for Research, Emory University School of Medicine, Atlanta, Georgia; President, the American University of Beirut, Beirut, Lebanon.

    • Title:Holland-Frei cancer medicine / editors, Robert C. Bast, Jr, MD, Vice President for Translational Research, MD Anderson Cancer Center, Houston, Texas, Carlo M. Croce, MD, Distinguished University Professor, The John W. Wolfe in Human Cancer Genetics, Professor and Chair, Department of Molecular Virology, Immunology and Medical Genetics, The Wexner Medical Center, The Ohio State University, Columbus, Ohio, William Hait, PhD, Global Head, Research and Development, Janssen Pharmaceutical Companies of Johnson and Johnson, Raritan, New Jersey, Waun Ki Hong, MD, DMSc (Hon), Professor of Thoracic/Head and Neck Medical Oncology, American Cancer Society Professor, Samsung Distinguished University Chair in Cancer Medicine Emeritus, The University of Texas MD Anderson Cancer Center, Houston, Texas, Donald W. Kufe, MD, Distinguished Physician Dana-Farber Cancer Institute, Professor of Medicine, Harvard Medical School, Leader, Translational Pharmacology and Early Therapeutic Trials Program, Dana-Farbor/Harvard Cancer Center, Boston, Massachusetts, Martine Piccart-Gebhart, MD, PhD, Professor of Oncology, UniversiteĢ Libre de Bruxelles (ULB), Head of the MEdicine Department, Jules Bordet Institute, Brussels, Belgium, Raphael E. Pollock, MD, PhD, FACS, Professor and Director, Division of Surgical Oncology, Surgeon in Chief, James Comprehensive Cancer Center, Surgeon in Chief, The Ohio State University Health System, The Ohio State University Wexner Medical Center, Columbus, Ohio, Ralph R. Weichselbaum, MD, Professor and Director, National Center for Liver Cancer, China; Eastern Hepatobiliary Surgery Hospital, Shanghai, China, Hongyang Wang, MD, Professor and Director, National Center for Liver Cancer, China; Eastern Hepatobiliary Surgery Hospital, Shanghai, China, James F. Holland, MD, ScD (hc), Distinguished Professor of Neoplastic Disease, Director of Derald H. Ruttenberg Cancer Centerm Ichn School of Medicine at Mount Sinai, New York, New York ; associate editor Fadlo R. Khuri, MD, Executive Associate Dean for Research, Emory University School of Medicine, Atlanta, Georgia; President, the American University of Beirut, Beirut, Lebanon.
    •    
    • Variant Title:Cancer medicine
    • Other Contributors/Collections:Bast, Robert C., Jr. (Robert Clinton), 1943- editor.
    • Published/Created:Hoboken, New Jersey : John Wiley & Sons, Inc., 2016.
    • Holdings

       
    • Library of Congress Subjects:Cancer--Diagnosis.
      Cancer--Treatment.
    • Medical Subjects: Neoplasms.
    • Edition:Ninth edition.
    • Description:xxix, 1, 971 pages : illustrations (some color) ; 29 cm
    • Summary:"The original reference resource for medical oncologists, radiation oncologists, internists, and allied specialties involved in the treatment of cancer patients, Holland-Frei Cancer Medicine covers the ever-expanding field of current cancer science and clinical oncology practice. In this new ninth edition an outstanding editorial team from world-renowned medical centers continue to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging, and therapy. Holland-Frei Cancer Medicine, Ninth Edition, brings scientific principles to clinical practice and is a testament to the ethos that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology. This ninth edition features hundreds of full color illustrations, photographs, tables, graphs and algorithms that enhance understanding of complex topics and make this text an invaluable clinical tool. Over 15 brand new chapters covering the latest advances, including chapters on Cancer Metabolism, Bioinformatics, Biomarker Based Clinical Trial Design, Health Services Research and Survivorship bring this comprehensive resource up-to-date. Each chapter contains overview boxes, select references and other pedagogic features, designed to make the content easy to access and absorb"-- Provided by publisher.
    • Notes:Preceded by Holland-Frei cancer medicine 8, 2010.
      Includes bibliographical references and index.
    • ISBN:9781118934692 (hardback)
      1118934695 (hardback)
    • Contents:Machine generated contents note: 1. Cardinal manifestations of cancer
      2. Biological hallmarks of cancer / James F. Holland / Waun Ki Hong / Donald W Kufe / Robert C. Bast Jr / William N. Hait / Raphael E. Pollock / Ralph R. Weichselbaum
      3. Molecular biology, genomics, proteomics and mouse models of human cancer / Douglas Hanahan / Robert A. Weinberg
      4. Oncogenes / Srinivas R. Viswanathan / David A. Tuveson / Matthew Meyerson
      5. Tumor suppressor genes / Marco A. Pierotti / Milo Frattini / Francesca Molinari / Gabriella Sozzi / Carlo M. Croce
      6. Epigenetic contributions to human cancer / David Cosgrove / Ben Ho Park / Bert Vogelstein
      7. Cancer genomics and evolution / James G. Herman / Stephen B. Baylin
      8. Chromosomal aberrations in cancer / William P.D. Hendricks / Aleksandar Sekulic / Alan H. Bryce / Muhammed Murtaza / Pilar Ramos / Jeffrey M. Trent
      9. MicroRNA expression in cancer / David J. Vander Weele / Megan E. McNerney / Michelle M. Le Beau
      10. Aberrant signaling pathways in cancer / Serge Patrick Nana-Sinkam / Mario Acunzo / Carlo M. Croce
      11. Differentiation therapy / Luca Grumolato / Stuart A. Aaronson
      12. Cancer stem cells / Sai-Juan Chen / Xiao-Jing Yan / Guang-Biao Zhou / Zhu Chen
      13. Cancer and cell death / Yadwinder S. Deol / Jill Granger / Max S. Wicha
      14. Cancer cell immortality: targeting telomerase / John C. Reed
      15. Cancer metabolism / Ilgen Mender / Zeliha Gunnur Dikmen / Woodring E. Wright / Jerry W. Shay
      16. Modeling therapy of late or early-stage metastatic disease in mice / Natalya N. Pavlova / Craig B. Thompson
      17. Tumor angiogenesis / Robert S. Kerbel / Marta Paez-Ribes / Shan Man / Ping Xu / Eric Guerin / William Cruz-Munoz / John M.L. Ebos
      18. Cancer bioinformatics / John V. Heymach / Amado Zurita-Saavedra / Scott Kopetz / Tina Cascone / Monique Nilsson
      19. Systems biology and genomics / John N. Weinstein
      20. Statistical innovations in cancer research / Saima Hassan / Laura M. Heiser / Joe W. Gray
      21. Biomarker-based clinical trial design in the era of genomic medicine / J. Jack Lee / Donald A. Berry
      22. Clinical informatics / Richard Simon / Martine Piccart-Gebhart
      23. Chemical carcinogenesis / Edward P. Ambinder
      24. Endocrine and genetic bases of hormone-related cancers / Lorne J. Hofseth / Ainsley Weston / Curtis C. Harris
      25. Ionizing radiation / Leslie Bernstein / Xia Pu / Jian Gu
      26. Ultraviolet radiation carcinogenesis / David J. Grdina
      27. Inflammation and cancer / James E. Cleaver / Susana Ortiz-Urda / Radhika Gulhar / Sarah T. Arron / Lionel Brookes 3rd / David L. Mitchell
      28. RNA tumor viruses / Jelena Todoric / Atsushi Umemura / Koji Taniguchi / Michael Karin
      29. Herpesviruses / Robert C. Gallo / Marvin S. Reitz
      30. Papillomaviruses and cervical neoplasia / Jeffrey I. Cohen
      31. Hepatitis viruses and hepatoma / Michael F. Herfs / Martin C. Chang / Christopher P. Crum
      32. Parasites / Hongyang Wang / Guangwen Cao / Jing Fu / Guishuai Lv
      33. burden of cancer worldwide: current and future perspectives / Mervat Z. El Azzouni / Radwa G. Diab
      34. Cancer epidemiology / Jacques Ferlay / Christopher P. Wild / Freddie Bray
      35. Behavioral approaches to cancer prevention / Xifeng Wu / Xia Pu / Stephanie C. Melkonian / Margaret R. Spitz
      36. Diet and nutrition in the etiology and prevention of cancer / Errol J. Philip / Jamie S. Ostroff
      37. Chemoprevention of cancer / Steven K. Clinton / Elizabeth M. Grainger / Edward L. Giovannucci
      38. Cancer screening and early detection / William N. William Jr / Waun Ki Hong / Scott M. Lippman
      39. Nexgen pathology: predicting clinical course and targeting disease causation / Otis W. Brawley
      40. Molecular diagnostics in cancer / Carlos Cordon-Cardo / Adolfo Firpo-Betancourt
      41. Principles of imaging / Roshni D. Kalachand / Bryan T. Hennessy / Robert C. Bast Jr / Gordon B. Mills
      42. Interventional radiology for the cancer patient / Lawrence H. Schwartz
      43. Principles of surgical oncology / Judy U. Ahrar / Michael J. Wallace / Rony Avritscher
      44. Principles of radiation oncology / Mark Bloomston / Kenneth K. Tanabe / Raphael E. Pollock / Donald L. Morton
      45. Principles of medical oncology / Philip P. Connell / Ralph R. Weichselbaum
      46. Palliative care and pain management / William N. Hait / James F. Holland / Emil Frei III / Donald W. Kufe / Robert C. Bast Jr / Waun Ki Hong
      47. Principles of psycho-oncology / Cardinale B. Smith
      48. Principles of cancer rehabilitation medicine / Jimmie C. Holland / Talia W. Wiesel
      49. Integrative oncology in cancer care / Michael D. Stubblefield / David C. Thomas / Kristjan T. Ragnarsson
      50. Health services research / Gabriel Lopez / Richard T. Lee / Alejandro Chaoul / M. Kay Garcia / Lorenzo Cohen
      51. Personalized medicine in oncology drug development / Michaela A. Dinan / Bradford R. Hirsch / Amy Abernethy
      52. Preclinical and early clinical development of chemotherapeutic drugs mechanism-based agents and biologics / Nicholas C. Dracopoli / Iqbal Grewal / Chris H. Takimoto / Peter F. Lebowitz
      53. Tumor growth kinetics / Axel-R. Hanauske / Daniel D. Von Hoff
      54. Principles of dose, schedule and combination therapy / Elizabeth Comen / Teresa A. Gilewski / Larry Norton
      55. Pharmacology / William N. Hait / Joseph P. Eder
      56. Folate antagonists / Manish R. Sharma / Mark J. Ratain
      57. Pyrimidine and purine antimetabolites / Peter D. Cole / Lisa Figueiredo / Joseph R. Bertino
      58. Alkylating agents and platinum antitumor compounds / Robert B. Diasio
      59. DNA topoisomerase targeting drugs / Zahid H. Siddik
      60. Agents targeting microtubules and mitotic processes / Anish Thomas / Susan Bates / William D. Figg Sr / Yves Pommier
      61. Endocrine therapy for hormone receptor-positive breast cancer / Eric K. Rowinsky
      62. Drug resistance and its clinical circumvention / Aman U. Buzdar / Shaheenah Dawood / Harold A. Harvey / Virgil Craig Jordan
      63. Cytokines, interferon and hematopoietic growth factors / Jeffrey A. Moscow / Kenneth H. Cowan / Branimir I. Sikic
      64. Monoclonal serotherapy / Suhendan Ekmekcioglu / Elizabeth A. Grimm
      65. Vaccines and immunostimulants / Robert C. Bast Jr / Arthur E. Frankel / Michael R. Zalutsky
      66. Cell-based cancer immunotherapy / James L. Gulley / Jeffery Schlom / James W. Hodge
      67. Cancer immunotherapy / Judy S. Moyes / Laurence J. Cooper / Krina K. Patel
      68. Cancer gene therapy / James P. Allison / Sergio Quezada / Sangeeta Goswami / Jianjun Gao / Padmanee Sharma / Sumit K. Subudhi / Karl Peggs
      69. Cancer nanotechnology / Haruko Tashiro / Malcolm Brenner
      70. Hematopoietic cell transplantation / Robert S. Langer / Danny Liu / Jinjun Shi / Yanlan Liu
      71. Principles of pediatric oncology / Elizabeth Shpall / Richard Champlin / Roy Jones
      72. Cancer and pregnancy / Teena Bhatla / William L. Carroll
      73. Cancer and aging / Jennifer K. Litton
      74. Disparities in cancer care / Hyman B. Muss / Harvey J. Cohen / Arti Hurria
      75. Neoplasms in acquired immunodeficiency syndrome / Otis W. Brawley
      76. Cancer survivorship: new challenge in cancer medicine / Jeremy S. Abramson / David T. Scadden
      77. Primary and metastatic neoplasms of the brain in adults / Julia H. Rowland
      78. Neoplasms of the eye / Lisa M. DeAngelis
      79. Neoplasms of the endocrine glands: pituitary neoplasms / Jasmine H. Francis / Amy C. Schefler / David H. Abramson
      80. Neoplasms of the thyroid / Margaret Pain / Chirag D. Gandhi / Kalmon D. Post
      81. Neoplasms of the adrenal cortex / Maria E. Cabanillas / Steven I. Sherman / Stephen Y. Lai
      82. Tumors of the diffuse neuroendocrine and gastroenteropancreatic system / Tito Fojo
      83. Neoplasms of the head and neck / Evan Vosburgh
      84. Cancer of the lung / Renata Ferrarotto / Michael E. Kupferman / Merrill S. Kies / Adam S. Garden
      85. Malignant pleural mesothelioma / Roy S. Herbst / Charles Lu / Daniel Morgensztern / Anne Chiang / Amir Onn / Boris Sepesi / Ara A. Vaporciyan / Joe Y. Chang / Ritsuko K. Komaki / Ignacio L. Wistuba
      86. Thymomas and thymic tumors / Daniel R. Gomez / Anne S. Tsao / Haining Yang / Harvey L. Pass
      87. Tumors of the heart and great vessels / Ronan J. Kelly / Alberto M. Marchevsky
      88. Primary germ cell tumors of the thorax / Anthony F. Yu / Sai-Ching Jim Yeung / Carmen P. Escalante / Sarina van der Zee / A.P. Chahinian / Valentin Fuster
      89. Neoplasms of the esophagus / John D. Hainsworth / F. Anthony Greco
      90. Carcinoma of the stomach / Stephen G. Swisher / David C. Rice / Jaffer A. Ajani / Ritsuko K. Komaki / Mark K. Ferguson / Max W. Sung / Virginia R. Litle / Steven J. Chmura
      91. Primary neoplasms of the liver / Carl Schmidt / Mariela Blum Murphy / James C. Yao / Christopher H. Crane
      92. Gallbladder and bile duct cancer / Junichi Shindoh / Kristoffer W. Brudvik / Jean-Nicolas Vauthey
      93. Neoplasms of the exocrine pancreas / Ahmed O. Kaseb / Marc Uemura / Melanie B. Thomas / Steven A. Curley
      94. Neoplasms of the small intestine, vermiform appendix and peritoneum and carcinoma of the colon and rectum / Robert A. Wolff / Christopher H. Crane / Donghui Li / Douglas B. Evans / Anirban Maitra / Susan Tsai
      95. Neoplasms of the anus / Georgia M. Beasley / Zhifei Sun / Daniel P. Nussbaum / Douglas S. Tyler
      Contents note continued: 96. Renal cell carcinoma / Bruce D. Minsky / Jose G. Guillem
      97. Urothelial cancer / Earle F. Burgess / Stephen B. Riggs / Brian I. Rini / Derek Raghavan
      98. Neoplasms of the prostate / Derek Raghavan / Richard Cote / Earle F Burgess / Stephen B. Riggs / Michael Haake
      99. Tumors of the penis and the urethra / Christopher J. Logothetis / Jeri Kim / John W. Davis / Brian F. Chapin / Deborah Kuban / Eleni Efstathiou / Ana Aparicio
      100. Testis cancer / James F. Holland / Raymond S. Lance / Donald F. Lynch Jr
      101. Neoplasms of the vulva and vagina / Christian Kollmannsberger / Craig R. Nichols / Siamak Daneshmand / Eric K. Hansen / Christopher L. Corless / Bruce J. Roth / Lawrence Einhorn
      102. Neoplasms of the cervix / Summer B. Dewdney / Jacob Rotmensch
      103. Endometrial cancer / Anuja Jhingran / Ana M. Rodriguez
      104. Epithelial ovarian, fallopian tube and peritoneal cancer / Jamal Rahaman / Karen Lu / Carmel J. Cohen
      105. Nonepithelial ovarian malignancies / Jonathan S. Berek / Michael L. Friedlander / Robert C. Bast Jr
      106. Molar pregnancy and gestational trophoblastic neoplasia / Jonathan S. Berek / Michael L. Friedlander / Robert C. Bast Jr
      107. Gynecologic sarcomas / Donald P. Goldstein / Ross S. Berkowitz / Neil S. Horowitz
      108. Neoplasms of the breast / Jamal Rahaman / Carmel J. Cohen
      109. Malignant melanoma / Hope S. Rugo / Melanie Majure / Anthony Dragun / Meredith Buxton / Laura Esserman
      110. Other skin cancers / Justin M. Ko / Susan M. Swetter / Jonathan S. Zager / Vernon K. Sondak / Scott E. Woodman / Kim A. Margolin
      111. Bone tumors / William G. Stebbins / Eric A. Millican / Victor A. Neel
      112. Soft tissue sarcomas / Timothy A. Damron
      113. myelodysplastic syndrome / Robert G. Maki / Chandrajit P. Raut / Brian O'Sullivan
      114. Acute myeloid leukemia in adults: mast cell leukemia and other mast cell neoplasms / Lewis R. Silverman
      115. Chronic myeloid leukemia / Richard M. Stone / Charles A. Schiffer
      116. Acute lymphoblastic leukemia / Jorge Cortes / Richard T. Silver / Hagop M. Kantarjian
      117. Chronic lymphocytic leukemia / Nitin Jain / Stefan Faderl / Hagop M. Kantarjian / Susan O'Brien
      118. Hodgkin lymphoma / Kanti R. Rai / Jacqueline C. Barrientos
      119. Non-Hodgkin's lymphoma / Carol S. Portlock / Anita Kumar / James Armitage
      120. Mycosis fungoides and Sezary syndrome / Arnold S. Freedman / Ann S. LaCasce
      121. Plasma cell tumors / Richard T. Hoppe / Youn H. Kim / Ranjana H. Advani
      122. Myeloproliferative neoplasms: essential thrombocythemia, primary myelofibrosis, polycythemia vera / Noopur Raje / Teru Hideshima / Andrew J. Yee / Kenneth C. Anderson
      123. Neoplasms of unknown primary site / Ayalew Tefferi
      124. Anorexia and cachexia / John D. Hainsworth / F. Anthony Greco
      125. Antiemetic therapy / Takao Ohnuma
      126. Neurologic complications of cancer / Patrick M. Forde / David S. Ettinger
      127. Dermatologic complications of cancer chemotherapy / Lisa M. DeAngelis
      128. Skeletal complications / Anisha B. Patel / Madeleine M. Duvic
      129. Hematologic complications and blood bank support / Michael A. Via / Ilya Iofin / Jeffrey I. Mechanick
      130. Coagulopathic complications of cancer patients / Richard M. Kaufman / Kenneth C. Anderson
      131. Urologic complications / Maria T De Sancho / Jacob H. Rand
      132. Cardiac complications / Rachel A. Sanford / Ala Abudayyeh / Christopher J. Logothetis / Nizar M. Tannir
      133. Respiratory complications / Michael S. Ewer / Steven M. Ewer / Thomas Suter
      134. Gastrointestinal and hepatic complications in cancer patients / Vickie R. Shannon / George A. Eapen / Carlos A. Jimenez / Horiana B. Grosu / Rodolfo C. Morice / Lara Bashoura / Scott E. Evans / Roberto Adachi / Michael Kroll / Saadia A. Faiz / Diwakar D. Balachandran / Selvaraj E. Pravinkumar / Burton F. Dickey
      135. Oral complications of cancer and their treatment / Robert S. Bresalier / H. Franklin Herlong / Boris Blechacz
      136. Gonadal complications / Stephen T. Sonis / Anna Yuan
      137. Sexual dysfunction / Vignesh Narayanan / Catherine E. Klein
      138. Endocrine complications and paraneoplastic syndromes / Leslie R. Schover
      139. Infections in patients with cancer / Sai-Ching Jim Yeung / Robert F. Gagel
      140. Oncologic emergencies / Lior Nesher / Kenneth V.I. Rolston
      141. vision for twenty-first century healthcare / Sai-Ching Jim Yeung / Carmen P. Escalante.
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