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• Title:Chromatin deregulation in cancer / edited by Scott A. Armstrong, Dana-Farber Cancer Institute; Steven Henikoff, Fred Hutchinson Cancer Research Center; Christopher R. Vakoc, Cold Spring Harbor Laboratory.
  
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• Other Contributors/Collections:Armstrong, Scott A., editor.
  Henikoff, Steve, editor.
  Vakoc, Christopher R., editor.
  
• Published/Created:Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press, 2017.
  

• Holdings

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  • Location:WOODWARD LIBRARY stacksWhere is this?
    
  • Call Number: QZ202 .C557 2017
    
  • Number of Items:1
    
  • Status:Available
    

   
• Library of Congress Subjects:Cancer--Genetic aspects.
  Chromosome abnormalities.
  Mutation (Biology)
  
• Medical Subjects: Neoplasms--genetics.
  
• Description:vii, 382 pages : illustrations ; 27 cm
  
• Series:Cold Spring Harbor perspectives in medicine.
  
• Summary:"The machinery that controls how DNA is packaged and genes are activated plays an important role in cancer. This book examines the functions of components of this machinery, how they can be dysregulated, and the prospects for targeting them therapeutically. Highlights include: - PRC2 polycomb complex - Therapy- Lysine demethylase inhibitors - Epigenetic mechanisms of therapy resistance and tumor heterogeneity - Long non-coding RNA"-- Provided by publisher.
  
• Notes:Includes bibliographical references and index.
  
• ISBN:9781621821403 (hardback)
  1621821404 (hardback)
  
• Contents:Machine generated contents note: Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer / Kristian Helin
  Role of Nuclear Receptor
  Binding SET Domain Family Histone Lysine Methytransferases in Cancer / Jonathan D. Licht
  Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia / Scott A. Armstrong
  Oncogenic Mechanisms of Histone H3 Mutations / Chao Lu
  MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer / Ali Shilatifard
  Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer / Gerald R. Crabtree
  DNMT3A in Leukemia / Margaret A. Goodell
  TET2 in Normal and Malignant Hematopoiesis / Ross L. Levine
  Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer / Siavash K. Kurdistani
  Role of Additional Sex Combs-Like Proteins in Cancer / Omar Abdel-Wahab
  SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation / Ian J. Davis
  ATRX and DAXX: Mechanisms and Mutations / Emily Bernstein
  Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer / Alea A. Mills
  Cohesin Mutations in Cancer / Ana Losada
  HDACs and HDAC Inhibitors in Cancer Development and Therapy / Edward Seto
  DNA Hypomethylating Drugs in Cancer Therapy / Patricia Kropf
  Targeting Cancer Cells with BET Bromodomain Inhibitors / Christopher R. Vakoc
  Histone Lysine Demethylase Inhibitors / Yang Shi
  Mechanisms of Nucleosome Dynamics In Vivo / Steven Henikoff
  Nonhistone Lysine Methylation in the Regulation of Cancer Pathways / Or Gozani
  Long Noncoding RNAs: At the Intersection of Cancer and Chromatin Biology / Howard Y. Chang.