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    Molecular biology of cancer : mechanisms, targets, and therapeutics / Lauren Pecorino, University of Greenwich.

    • Title:Molecular biology of cancer : mechanisms, targets, and therapeutics / Lauren Pecorino, University of Greenwich.
    •    
    • Author/Creator:Pecorino, Lauren, author.
    • Published/Created:Oxford, United Kingdom : Oxford University Press, [2016]
      ©2016
    • Holdings

       
    • Library of Congress Subjects:Cancer--Molecular aspects.
      Cancer cells.
    • Medical Subjects: Neoplasms--etiology.
      Cell Transformation, Neoplastic--genetics.
      Antineoplastic Agents--therapeutic use.
    • Edition:Fourth edition.
    • Description:xviii, 375 pages : illustrations (some color) ; 25 cm
    • Summary:"The most engaging and accessible account of cancer biology that makes the link between our understanding of cancer and the development of new therapeutics crystal clear. -- Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an engaging and manageable route into the complex subject of cancer biology. Using the hallmarks of cancer as a foundation, the book describes the cellular and molecular mechanisms underpinning the transformation of healthy cells into cancer cells. -- after discussing a specific biological hallmark of cancer, each chapter shows how this knowledge can be directly applied to the development of new targeted therapies, giving you a clear appreciation of how the theory translated to tackling the disease. The new edition gives a contemporary account of the field, drawing on the latest research but presenting it in a manner that you will find easy to understand. -- New to this edition: *New full colour diagrams help you visualize key concepts more effectively *Separate chapters for growing areas of cancer biology: Metastasis, Angiogenesis, Infectious Agents and Inflammation, and Technology and Drug and Diagnostics Development *Coverage of range of new topics, including immune checkpoints, studying gene function by CRISPR-Ca9, newly proposed mechanisms for the role of obesity in cancer, non-coding RNAs, and the role of exosomes in intercellular communication *Latest details of newly approved therapeutics" -- from back of book.
    • Notes:Includes bibliographical references and index.
    • ISBN:9780198717348
      0198717342
    • Contents:Machine generated contents note: 1. Introduction
      1.1. What is cancer?
      1.2. Evidence suggests that cancer is a disease of the genome at the cellular level
      1.3. Influential factors in human carcinogenesis
      1.4. Principles of conventional cancer therapies
      1.5. Clinical trials
      1.6. role of molecular targets in cancer therapies
      2. DNA structure and stability: mutations versus repair
      2.1. Gene structure
      -two parts of a gene: the regulatory region and the coding region
      2.2. Mutations
      2.3. Carcinogenic agents
      2.4. DNA repair and predispositions to cancer
      Therapeutic strategies
      2.5. Conventional therapies: chemotherapy and radiation therapy
      2.6. Strategies that target DNA repair pathways
      3. Regulation of gene expression
      3.1. Transcription factors and transcriptional regulation
      3.2. Chromatin structure
      3.3. Epigenetic regulation of transcription
      3.4. Evidence of a role for epigenetics in carcinogenesis
      3.5. Long non-coding RNAs
      3.6. MicroRNAs (miRNAs) and regulation of mRNA expression
      3.7. Telomeres and telomerase
      Therapeutic strategies
      3.8. Epigenomic and histonomic drugs
      3.9. Non-coding RNAs for diagnosis
      3.10. Telomerase inhibitors
      4. Growth factor signaling and oncogenes
      4.1. Epidermal growth factor signaling: an important paradigm
      4.2. Oncogenes
      Therapeutic strategies
      4.3. Kinases as drug targets
      5. cell cycle
      5.1. Cyclins and cyclin-dependent kinases (cdks)
      5.2. Mechanisms of cdk regulation
      5.3. Progression through the G1 checkpoint
      5.4. G2 checkpoint
      5.5. mitotic checkpoint
      5.6. cell cycle and cancer
      Therapeutic strategies
      5.7. Cyclin-dependent kinase inhibitors
      5.8. Other cell cycle kinase targets
      5.9. Inhibitors of the mitotic spindle
      6. Growth inhibition and tumor suppressor genes
      6.1. Definitions of tumor suppressor genes
      6.2. retinoblastoma gene
      6.3. Mutations in the RB pathway and cancer
      6.4. p53 pathway
      6.5. Mutations in the p53 pathway and cancer
      6.6. Interaction of DNA viral protein products with RB and p53
      Therapeutic strategies
      6.7. Targeting of the p53 pathway
      7. Apoptosis
      7.1. Molecular mechanisms of apoptosis
      7.2. Apoptosis and cancer
      7.3. Apoptosis and chemotherapy
      Therapeutic strategies
      7.4. Apoptotic drugs
      8. Cancer stem cells and the regulation of self-renewal and differentiation pathways: focus on colon cancer and leukemias
      8.1. Cancer stem cells
      8.2. regulation of differentiation by gene expression
      Therapeutic strategies
      8.3. Inhibitors of the Wnt pathway
      8.4. Inhibitors of the Hh pathway
      8.5. Inhibitors of PcG proteins
      8.6. Leukemia and differentiation therapies
      9. Metastasis
      9.1. How do tumors spread?
      9.2. process of metastasis
      9.3. Invasion and the epithelial-mesenchymal transition
      9.4. Intravasation
      9.5. Transport
      9.6. Extravasation
      9.7. Metastatic colonization
      Therapeutic strategies
      9.8. Metalloproteinase inhibitors (MPIs)
      9.9. Strategies for restoring metastasis suppressors
      9.10. Targeting several steps of metastasis at once
      10. Angiogenesis
      10.1. angiogenic switch
      10.2. Cell behavior during angiogenic sprouting
      10.3. Other means of tumor neovascularization
      Therapeutic strategies
      10.4. Anti-angiogenic therapy
      10.5. Vascular targeting by vascular disrupting agents
      11. Nutrient and hormone effects on the genome
      11.1. Introduction to food and cancer
      11.2. Causative factors
      11.3. Preventative factors: microconstituents of fruits and vegetables
      11.4. Reprogramming energy metabolism in tumor cells
      -an emerging hallmark of cancer
      11.5. Genetic polymorphisms and diet
      11.6. Vitamin D: a link between nutrients and hormone action
      11.7. Hormones and cancer
      Therapeutic strategies
      11.8. "Enhanced" foods and dietary supplements for chemoprevention
      11.9. Drugs that target energy pathways
      11.10. Drugs that target estrogen
      12. Tumor immunology and immunotherapy
      12.1. Lymphocytes: B cells and T cells
      12.2. tumor suppressive roles of the immune system
      12.3. Immune checkpoints
      12.4. Cancer immunoediting and tumor promotion
      12.5. Mechanisms of avoiding immune destruction
      Therapeutic strategies
      12.6. Therapeutic antibodies
      12.7. Cancer vaccines
      12.8. Immune checkpoint blockades
      12.9. Adoptive T-cell transfer, modified T-cell receptors, and chimeric antigen receptors
      12.10. Oncolytic viruses and virotherapy
      13. Infectious agents and inflammation
      13.1. Identifying infectious agents as carcinogens
      13.2. Inflammation and cancer
      Therapeutic strategies
      13.3. National Vaccination Program Against Hepatitis B Virus in Taiwan
      13.4. Eradication of H. pylori and the relationship to prevention of gastric cancer
      13.5. Cancer vaccines to prevent cervical cancer
      13.6. Inhibition of inflammation
      14. Technology and drug and diagnostics development
      14.1. Microarrays and gene expression profiling
      14.2. Analysis of biomarkers for diagnostics and prognostics
      14.3. Studying gene function by CRISPR-Cas9
      14.4. Imaging
      14.5. Cancer nanotechnology
      14.6. Strategies of drug development
      14.7. Development of imatinib
      14.8. Second-and third-generation therapeutics
      14.9. Improved clinical trial design
      14.10. Personalized medicine and bioinformatics
      14.11. Are we making progress?.
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