Holdings Information
Molecular biology of cancer : mechanisms, targets, and therapeutics / Lauren Pecorino, University of Greenwich.
Bibliographic Record Display
-
Title:Molecular biology of cancer : mechanisms, targets, and therapeutics / Lauren Pecorino, University of Greenwich.
-
Author/Creator:Pecorino, Lauren, author.
-
Published/Created:Oxford, United Kingdom : Oxford University Press, [2016]
©2016
-
Holdings
Holdings Record Display
-
Location:WOODWARD LIBRARY stacksWhere is this?
-
Call Number: QZ202 .P369m 2016
-
Number of Items:1
-
Status:c.1 On loan - Due on 04-08-2024
-
Location:WOODWARD LIBRARY stacksWhere is this?
-
Library of Congress Subjects:Cancer--Molecular aspects.
Cancer cells.
-
Medical Subjects: Neoplasms--etiology.
Cell Transformation, Neoplastic--genetics.
Antineoplastic Agents--therapeutic use.
-
Edition:Fourth edition.
-
Description:xviii, 375 pages : illustrations (some color) ; 25 cm
-
Summary:"The most engaging and accessible account of cancer biology that makes the link between our understanding of cancer and the development of new therapeutics crystal clear. -- Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an engaging and manageable route into the complex subject of cancer biology. Using the hallmarks of cancer as a foundation, the book describes the cellular and molecular mechanisms underpinning the transformation of healthy cells into cancer cells. -- after discussing a specific biological hallmark of cancer, each chapter shows how this knowledge can be directly applied to the development of new targeted therapies, giving you a clear appreciation of how the theory translated to tackling the disease. The new edition gives a contemporary account of the field, drawing on the latest research but presenting it in a manner that you will find easy to understand. -- New to this edition: *New full colour diagrams help you visualize key concepts more effectively *Separate chapters for growing areas of cancer biology: Metastasis, Angiogenesis, Infectious Agents and Inflammation, and Technology and Drug and Diagnostics Development *Coverage of range of new topics, including immune checkpoints, studying gene function by CRISPR-Ca9, newly proposed mechanisms for the role of obesity in cancer, non-coding RNAs, and the role of exosomes in intercellular communication *Latest details of newly approved therapeutics" -- from back of book.
-
Notes:Includes bibliographical references and index.
-
ISBN:9780198717348
0198717342
-
Contents:Machine generated contents note: 1. Introduction
1.1. What is cancer?
1.2. Evidence suggests that cancer is a disease of the genome at the cellular level
1.3. Influential factors in human carcinogenesis
1.4. Principles of conventional cancer therapies
1.5. Clinical trials
1.6. role of molecular targets in cancer therapies
2. DNA structure and stability: mutations versus repair
2.1. Gene structure
-two parts of a gene: the regulatory region and the coding region
2.2. Mutations
2.3. Carcinogenic agents
2.4. DNA repair and predispositions to cancer
Therapeutic strategies
2.5. Conventional therapies: chemotherapy and radiation therapy
2.6. Strategies that target DNA repair pathways
3. Regulation of gene expression
3.1. Transcription factors and transcriptional regulation
3.2. Chromatin structure
3.3. Epigenetic regulation of transcription
3.4. Evidence of a role for epigenetics in carcinogenesis
3.5. Long non-coding RNAs
3.6. MicroRNAs (miRNAs) and regulation of mRNA expression
3.7. Telomeres and telomerase
Therapeutic strategies
3.8. Epigenomic and histonomic drugs
3.9. Non-coding RNAs for diagnosis
3.10. Telomerase inhibitors
4. Growth factor signaling and oncogenes
4.1. Epidermal growth factor signaling: an important paradigm
4.2. Oncogenes
Therapeutic strategies
4.3. Kinases as drug targets
5. cell cycle
5.1. Cyclins and cyclin-dependent kinases (cdks)
5.2. Mechanisms of cdk regulation
5.3. Progression through the G1 checkpoint
5.4. G2 checkpoint
5.5. mitotic checkpoint
5.6. cell cycle and cancer
Therapeutic strategies
5.7. Cyclin-dependent kinase inhibitors
5.8. Other cell cycle kinase targets
5.9. Inhibitors of the mitotic spindle
6. Growth inhibition and tumor suppressor genes
6.1. Definitions of tumor suppressor genes
6.2. retinoblastoma gene
6.3. Mutations in the RB pathway and cancer
6.4. p53 pathway
6.5. Mutations in the p53 pathway and cancer
6.6. Interaction of DNA viral protein products with RB and p53
Therapeutic strategies
6.7. Targeting of the p53 pathway
7. Apoptosis
7.1. Molecular mechanisms of apoptosis
7.2. Apoptosis and cancer
7.3. Apoptosis and chemotherapy
Therapeutic strategies
7.4. Apoptotic drugs
8. Cancer stem cells and the regulation of self-renewal and differentiation pathways: focus on colon cancer and leukemias
8.1. Cancer stem cells
8.2. regulation of differentiation by gene expression
Therapeutic strategies
8.3. Inhibitors of the Wnt pathway
8.4. Inhibitors of the Hh pathway
8.5. Inhibitors of PcG proteins
8.6. Leukemia and differentiation therapies
9. Metastasis
9.1. How do tumors spread?
9.2. process of metastasis
9.3. Invasion and the epithelial-mesenchymal transition
9.4. Intravasation
9.5. Transport
9.6. Extravasation
9.7. Metastatic colonization
Therapeutic strategies
9.8. Metalloproteinase inhibitors (MPIs)
9.9. Strategies for restoring metastasis suppressors
9.10. Targeting several steps of metastasis at once
10. Angiogenesis
10.1. angiogenic switch
10.2. Cell behavior during angiogenic sprouting
10.3. Other means of tumor neovascularization
Therapeutic strategies
10.4. Anti-angiogenic therapy
10.5. Vascular targeting by vascular disrupting agents
11. Nutrient and hormone effects on the genome
11.1. Introduction to food and cancer
11.2. Causative factors
11.3. Preventative factors: microconstituents of fruits and vegetables
11.4. Reprogramming energy metabolism in tumor cells
-an emerging hallmark of cancer
11.5. Genetic polymorphisms and diet
11.6. Vitamin D: a link between nutrients and hormone action
11.7. Hormones and cancer
Therapeutic strategies
11.8. "Enhanced" foods and dietary supplements for chemoprevention
11.9. Drugs that target energy pathways
11.10. Drugs that target estrogen
12. Tumor immunology and immunotherapy
12.1. Lymphocytes: B cells and T cells
12.2. tumor suppressive roles of the immune system
12.3. Immune checkpoints
12.4. Cancer immunoediting and tumor promotion
12.5. Mechanisms of avoiding immune destruction
Therapeutic strategies
12.6. Therapeutic antibodies
12.7. Cancer vaccines
12.8. Immune checkpoint blockades
12.9. Adoptive T-cell transfer, modified T-cell receptors, and chimeric antigen receptors
12.10. Oncolytic viruses and virotherapy
13. Infectious agents and inflammation
13.1. Identifying infectious agents as carcinogens
13.2. Inflammation and cancer
Therapeutic strategies
13.3. National Vaccination Program Against Hepatitis B Virus in Taiwan
13.4. Eradication of H. pylori and the relationship to prevention of gastric cancer
13.5. Cancer vaccines to prevent cervical cancer
13.6. Inhibition of inflammation
14. Technology and drug and diagnostics development
14.1. Microarrays and gene expression profiling
14.2. Analysis of biomarkers for diagnostics and prognostics
14.3. Studying gene function by CRISPR-Cas9
14.4. Imaging
14.5. Cancer nanotechnology
14.6. Strategies of drug development
14.7. Development of imatinib
14.8. Second-and third-generation therapeutics
14.9. Improved clinical trial design
14.10. Personalized medicine and bioinformatics
14.11. Are we making progress?.